DRSC/TRiP Functional Genomics Resources

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Protein Alignment Meltrin and Adam15

DIOPT Version :9

Sequence 1:NP_001027575.1 Gene:Meltrin / 3772109 FlyBaseID:FBgn0265140 Length:1407 Species:Drosophila melanogaster
Sequence 2:NP_001032811.2 Gene:Adam15 / 11490 MGIID:1333882 Length:864 Species:Mus musculus


Alignment Length:947 Identity:287/947 - (30%)
Similarity:414/947 - (43%) Gaps:211/947 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 QISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQ-NASRGATPGHVVTTFTKTEVDLCHYQGHIRG 144
            :|||....| ..|:..||..||:......:.|| :.:|..:.|:        .::.|.|:|.::|
Mouse    71 RISLELDSE-SHVLELLQNRDLIPGRPTLVWYQPDGTRMVSEGY--------SLENCCYRGRVQG 126

  Fly   145 KPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQ-------DDHYLLKQADMHPTNATCG 202
            .|.|.|:|..|.|....||:...:.|.:..   |.|.||       .||.||        ..||.
Mouse   127 HPSSWVSLCACSGIRGLIVLSPERGYTLEL---GPGDLQRPVISRIQDHLLL--------GHTCA 180

  Fly   203 YDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYS 267
            ...|                     .|:|.|.     ...||.::..|   .:|.|......|  
Mouse   181 PSWH---------------------ASVPTRA-----GPDLLLEQHHA---HRLKRDVVTETK-- 214

  Fly   268 SYVELVIVVDN---KVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEF 329
             .||||||.||   :.|.:||:...:..:    .|.:::..:.|||:.|||||:..|.:.|.||.
Mouse   215 -IVELVIVADNSEVRKYPDFQQLLNRTLE----AALLLDTFFQPLNVRVALVGLEAWTQHNLIEM 274

  Fly   330 SSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPN 394
            ||:..:.|.|||.:|.|.|:...|:|:|||:|..:|:|.:||.|::..||:.::||||:|.||.:
Mouse   275 SSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNSICSPDFSGGVNMDHSTS 339

  Fly   395 PAMVATTMAHEMGHNFGMEHDT--SDCHCRD----EKCVMAASSTSFIP-VNWSSCSIDQLTIAF 452
            ...||:::|||:||:.|::||:  ..|.|..    :.|:|.| ||.|:| :|:|:||...|..|.
Mouse   340 ILGVASSIAHELGHSLGLDHDSPGHSCPCPGPAPAKSCIMEA-STDFLPGLNFSNCSRQALEKAL 403

  Fly   453 SRGMNYCL-RNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCAT-GE 515
            ..||..|| ..:|.....|..|||.||:||||||||.|:.|.:.||:..||.|. ..|.||: |.
Mouse   404 LEGMGSCLFERQPSLAPMSSLCGNMFVDPGEQCDCGFPDECTDPCCDHFTCQLR-PGAQCASDGP 467

  Fly   516 CCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSN 580
            ||.  .|:...||..||...::|||||:|.|:|..||:|:...|.|||..|:|.|.||.|.|::.
Mouse   468 CCQ--NCKLHPAGWLCRPPTDDCDLPEFCPGDSSQCPSDIRLGDGEPCASGEAVCMHGRCASYAR 530

  Fly   581 QCRTLWGPTGDNSEH-C-YNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHC---------- 633
            ||::||||....:.. | ...||.|...|:||.:. ..:::.|..:.|.||.|.|          
Mouse   531 QCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRSP-GGSYMPCAPRDVMCGQLQCQWGRSQPLLG 594

  Fly   634 ---IHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVD 695
               ..|:|.||   .:...|:.|::.            :|||.....|.|...|..||...:|:.
Mouse   595 SVQDRLSEVLE---ANGTQLNCSWVD------------LDLGNDVAQPLLALPGTACGPGLVCIG 644

  Fly   696 QRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCS---KAGSGGSPDSGPATDP 757
            .||.|||.:.    .:.|...|:|:|:|:|.|||.|:.|:....|.   ||.|            
Mouse   645 HRCQPVDLLG----AQECRRKCHGHGVCDSSGHCRCEEGWAPPDCMTQLKATS------------ 693

  Fly   758 NGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTG 822
            :.:.|....|.:|...|| :.|.:|.           |.:|...:.:..|.|  ...|..|  :.
Mouse   694 SLTTGLLLSLLLLLVLVL-LGASYWH-----------RARLHQRLCQLKGSS--CQYRAPQ--SC 742

  Fly   823 PPPSNGLLKSTPSSTDDMDSALLK---SPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNV 884
            ||...|..:.....|....::::.   .||...|...:..|...    .|.|.|:|         
Mouse   743 PPERPGPPQRAQQMTGTKQASVVSFPVPPSRPLPPNPVPKKLQA----ALADRSNP--------- 794

  Fly   885 AFVQPTVQQDGPQRMAPPPPVVK--PGTAPIHPPSPKPEATWVRPAPALPP--------PNPGST 939
                       |.|..|..|||:  ....|..||.|:      :|.||.|.        |.||..
Mouse   795 -----------PTRPLPADPVVRRPKSQGPTKPPPPR------KPLPANPQGQHPPGDLPGPGDG 842

  Fly   940 ARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAPPVP 976
            :.|::                      .|||.|||.|
Mouse   843 SLPLV----------------------VPSRPAPPPP 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeltrinNP_001027575.1 Pep_M12B_propep 64..174 CDD:279848 26/93 (28%)
Reprolysin 269..464 CDD:279729 82/205 (40%)
ZnMc_adamalysin_II_like 269..462 CDD:239797 82/203 (40%)
Disintegrin 479..555 CDD:278623 36/76 (47%)
ACR 558..701 CDD:214743 47/157 (30%)
Adam15NP_001032811.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 18..45
Pep_M12B_propep 67..155 CDD:279848 26/92 (28%)
Cysteine switch. /evidence=ECO:0000250 177..184 2/6 (33%)
Reprolysin 214..414 CDD:279729 83/207 (40%)
ZnMc_adamalysin_II_like 214..412 CDD:239797 82/205 (40%)
DISIN 431..504 CDD:214490 36/75 (48%)
ACR 509..650 CDD:214743 47/156 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 736..864 39/176 (22%)
SH3-binding. /evidence=ECO:0000255 816..822 3/11 (27%)
SH3-binding. /evidence=ECO:0000255 851..857 4/5 (80%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 155 1.000 Domainoid score I4215
eggNOG 1 0.900 - - E1_KOG3607
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 433 1.000 Inparanoid score I1692
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm43605
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR11905
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 1 1.000 - - X50
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.000

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