DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and Adam12

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_031426.2	Gene:	Adam12 / 11489	MGIID:	105378	Length:	903	Species:	Mus musculus

Alignment Length:	988	Identity:	316/988 - (31%)
Similarity:	465/988 - (47%)	Gaps:	174/988 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EEFSTYTVIRPQVEHGRTKRSLLT--------TLDATDGLHTPQISLSYTHEGKRVVVDLQRNDL 102
            ::..||.|.|         .|||:        ::.|.|  |...:::....|.:.:::.|:||:.
Mouse    36 DQRGTYEVAR---------ASLLSKDPGIPGQSIPAKD--HPDVLTVQLQLESRDLILSLERNEG 89

  Fly   103 LLPNSHFLRYQNASRGATPGHVV-----TTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGI 162
            |:.|           |.|..|.:     .:.|:...|.|:|.||::|...|||:||||.| |.|:
Mouse    90 LIAN-----------GFTETHYLQDGTDVSLTRNHTDHCYYHGHVQGDAASVVSLSTCSG-LRGL 142

  Fly   163 VIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGI 227
            ::...:||.:.|    .....|.:.|:....|......||..:::.:
Mouse   143 IMFENKTYSLEP----MKNTTDSYKLVPAESMTNIQGLCGSQHNKSN------------------ 185

  Fly   228 PSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVH 292
                |.::......:.:|.||...::.          |.:.|||||||.||:.::...::.:||.
Mouse   186 ----LTMEDVSPGTSQMRARRHKRETL----------KMTKYVELVIVADNREFQRQGKDLEKVK 236

  Fly   293 QYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNA 357
            |....|||.::..|.||||.:.||||.:||:.::...|.|...:|..||::|..||:....:|||
Mouse   237 QRLIEIANHVDKFYRPLNIRIVLVGVEVWNDIDKCSISQDPFTSLHEFLDWRKIKLLPRKSHDNA 301

  Fly   358 QLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSD--CH 420
            ||::...|.|..:|.|....:||.|.||||.|.||.:|...|.|:|||:||||||.|||.:  |.
Mouse   302 QLISGVYFQGTTIGMAPIMSMCTAEQSGGVVMDHSDSPLGAAVTLAHELGHNFGMNHDTLERGCS 366

  Fly   421 CR--DEK--CVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPE--RLFESPTCGNGFVE 479
            ||  .||  |:|..|:....|:.:||||...|..:..:||..||.|.||  :.|....||||:||
Mouse   367 CRMAAEKGGCIMNPSTGFPFPMVFSSCSRKDLEASLEKGMGMCLFNLPEVKQAFGGRKCGNGYVE 431

  Fly   480 PGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYC 544
            .||:||||.||.|.|.||||.||.| ..:|.||.|:||:  .|:.|..|:|||.:.|.|||||:|
Mouse   432 EGEECDCGEPEECTNRCCNATTCTL-KPDAVCAHGQCCE--DCQLKPPGTACRGSSNSCDLPEFC 493

  Fly   545 TGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLG 607
            ||.:.:|||:|:..|..||.|...||::|.|::|..||.|||||....:.. |:.: |:.|...|
Mouse   494 TGTAPHCPANVYLHDGHPCQGVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYG 558

  Fly   608 NCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKI-------VACR 665
            |||.:. ...|.:||.:...||.:.|        .|..|..|:..:.:|.:..|       :.||
Mouse   559 NCGKDS-KSAFAKCELRDAKCGKIQC--------QGGASRPVIGTNAVSIETNIPQQEGGRILCR 614

  Fly   666 TALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCH 730
            ...|.||....||||...|.||...|:|:::||..:...   |:.| |...|:|.|:||:|.:||
Mouse   615 GTHVYLGDDMPDPGLVLAGTKCAEGKICLNRRCQNISVF---GVHK-CAMQCHGRGVCNNRKNCH 675

  Fly   731 CDVGFGGESCSKAGSGGSPDSGP--ATDPNG-SVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGM 792
            |:..:....|.|.|.|||.||||  ..|..| :||       :...:|.::|..:.:|
Mouse   676 CEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTVG-------ILVSILCLLAAGFVVY------- 726

  Fly   793 LTRGKLADNIL--KSSGGSKPITTRTNQNGTGP-------PPSNGLLKSTPSSTDDMDSALLKSP 848
            |.|..|...:.  |.:...|......::..:||       .|..|||.:             ::|
Mouse   727 LKRKTLMRLLFTHKKTTMEKLRCVHPSRTPSGPHLGQAHHTPGKGLLMN-------------RAP 778

  Fly   849 SDSTPSAGLFGKFDGFTLRPLN-DASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTAP 912
            ..:||.       |..:|:..| |.|.|..       |...|.:|  .|||:.  .|:.:...||
Mouse   779 HFNTPK-------DRHSLKCQNMDISRPLD-------ARAVPQLQ--SPQRVL--LPLHQTPRAP 825

  Fly   913 IHPPSPKPEATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLKDSTEDLSPSRSAP---P 974
            ..|..|.|.:..||.|..:..|:|  ..:|:.:.|...:|.||...::      :|.:..|   |
Mouse   826 SGPARPLPASPAVRQAQGIRKPSP--PQKPLPADPLSRTSRLTSALVR------TPGQQEPGHRP 882

  Fly   975 VPLHADPKLNVKR 987
            .|:...||..|.|
Mouse   883 APIRPAPKHQVPR 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	34/122 (28%)
		Reprolysin	269..464	CDD:279729	87/200 (44%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	86/198 (43%)
		Disintegrin	479..555	CDD:278623	42/75 (56%)
		ACR	558..701	CDD:214743	50/151 (33%)
Adam12	NP_031426.2	Pep_M12B_propep	64..161	CDD:279848	31/114 (27%)
		Cysteine switch. /evidence=ECO:0000250	175..182		2/6 (33%)
		Reprolysin	212..414	CDD:279729	87/201 (43%)
		ZnMc_adamalysin_II_like	212..412	CDD:239797	86/199 (43%)
		DISIN	437..505	CDD:214490	38/70 (54%)
		ACR	508..650	CDD:214743	50/150 (33%)
		CAC1F_C	<751..>848	CDD:293490	30/127 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	753..790		10/56 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..903		23/85 (27%)
		SH3-binding, class II	824..830		3/5 (60%)
		SH3-binding, class I	830..837		2/6 (33%)
		SH3-binding, class II	846..852		2/7 (29%)
		NSP2-B_epitope	<848..>896	CDD:258894	14/56 (25%)
		SH3-binding, class I	852..858		1/5 (20%)
		SH3-binding, class I	881..887		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4215
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1692
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm43605
orthoMCL	1	0.900	-	-		OOG6_101958
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900