Protein Alignment Meltrin and ADAM29

DIOPT Version :9

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_001124175.1
• Gene: ADAM29 / 11086
• HGNCID: 207
• Length: 820
• Species: Homo sapiens
• Alignment Length: 1033
• Identity: 265/1033 - (25%)
• Similarity: 416/1033 - (40%)
• Gaps: 251/1033 - (24%)

  Fly     9 LPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDA 73
            :.:|||..||          ..|....|.....||  :..|...|:.|....|.|:
Human     1 MKMLLLLHCL----------GVFLSCSGHIQDEHP--QYHSPPDVVIPVRITGTTR--------- 44

  Fly    74 TDGLHTPQISLSY--THEGKRVVVDLQRNDLLLPNSHFLRYQNASRGA----TPGHVVTTFTKTE 132
              |: ||...|||  ...|::.::.::...||. :.|...:....:||    .|      |.:..
Human    45 --GM-TPPGWLSYILPFGGQKHIIHIKVKKLLF-SKHLPVFTYTDQGAILEDQP------FVQNN 99

  Fly   133 VDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP--------HIDGRGRLQDDHYLL 189
               |:|.|::.|.|||:|:||||.|...||:......|.|.|        |:..:...::..:..
Human   100 ---CYYHGYVEGDPESLVSLSTCFGGFQGILQINDFAYEIKPLAFSTTFEHLVYKMDSEEKQFST 161

  Fly   190 KQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSS 254
            .::.......||                               |:   ||        .:.|:|:
Human   162 MRSGFMQNEITC-------------------------------RM---EF--------EEIDNST 184

  Fly   255 QLIRGPYNANKYSSY---------VELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLN 310
            |         |.|||         ||:|:|:||.:|..::.|..|:.:....|.||::::...:.
Human   185 Q---------KQSSYVGWWIHFRIVEIVVVIDNYLYIRYERNDSKLLEDLYVIVNIVDSILDVIG 240

  Fly   311 IFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAG--GVVGKA 373
            :.|.|.|:.||...|.| ...|...::..:..::|..:.....:|.:.|.|.....|  |:  .|
Human   241 VKVLLFGLEIWTNKNLI-VVDDVRKSVHLYCKWKSENITPRMQHDTSHLFTTLGLRGLSGI--GA 302

  Fly   374 LKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPV 438
            .:| :||...|..:....:......:..:||.:|||.||.||...|.|...:|:|...:.   |:
Human   303 FRG-MCTPHRSCAIVTFMNKTLGTFSIAVAHHLGHNLGMNHDEDTCRCSQPRCIMHEGNP---PI 363

  Fly   439 -NWSSCSID---QLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNA 499
             .:|:||..   :.|:..::.:...:..|.  :|....||||.||.||:||||..:||....|..
Human   364 TKFSNCSYGDFWEYTVERTKCLLETVHTKD--IFNVKRCGNGVVEEGEECDCGPLKHCAKDPCCL 426

  Fly   500 QTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCD 564
            ..|.| :..:|||.|.||  ..|:...:|..||:..|||||||:|.|.|..||.|.:..|..||.
Human   427 SNCTL-TDGSTCAFGLCC--KDCKFLPSGKVCRKEVNECDLPEWCNGTSHKCPDDFYVEDGIPCK 488

  Fly   565 GGQAYCFHGTCRSHSNQCRTLWGPTGDN--SEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHV 626
             .:.||:..:|...:.|||.::| .|.|  ||.||.: ||.|.|:|:||..  |.|:::|....|
Human   489 -ERGYCYEKSCHDRNEQCRRIFG-AGANTASETCYKELNTLGDRVGHCGIK--NATYIKCNISDV 549

  Fly   627 NCGMLHCIHLNERLEFGMESAAVLSHSYISHDR-KIVACRTALVDLGLQTTDPGLTPNGAKCGVD 690
            .||.:.|.::.       |...:..|:.:...| ..:.|.:....||::..|.|...:|.:||:|
Human   550 QCGRIQCENVT-------EIPNMSDHTTVHWARFNDIMCWSTDYHLGMKGPDIGEVKDGTECGID 607

  Fly   691 KMCVDQRCLPVDAVRQKGMGKPC-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPA 754
            .:|:.:.|:.:..:...     | |..||..||||::.||||:..:...:|...|.|||.||||
Human   608 HICIHRHCVHITILNSN-----CSPAFCNKRGICNNKHHCHCNYLWDPPNCLIKGYGGSVDSGP- 666

  Fly   755 TDPNGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQN 819
              |......|:|.|:....::.:..|...||...|.                  ||||..:.:
Human   667 --PPKRKKKKKFCYLCILLLIVLFILLCCLYRLCKK------------------SKPIKKQQD-- 709

  Fly   820 GTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNV 884
                       ..|||:.:  :..:.:.|.:..|.:
Human   710 -----------VQTPSAKE--EEKIQRRPHELPPQS----------------------------- 732

  Fly   885 AFVQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPPPNPGSTARPIISPPKL 949
               ||.|.   |.:..||   |.|..:  ||.        |.|:.:.||..| |.::|.:.|
Human   733 ---QPWVM---PSQSQPP---VTPSQS--HPQ--------VMPSQSQPPVTP-SQSQPRVMP--- 774

  Fly   950 DSSTLTMVPLKDSTEDLSPSRSAPPV-PLHADPKLNVKRDGTIRRFASFLKKEEKPPL 1006
             |.:...|....|...|:||:|.||| |....|:|              :..:.:||:
Human   775 -SQSQPPVMPSQSHPQLTPSQSQPPVTPSQRQPQL--------------MPSQSQPPV 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	31/115 (27%)
		Reprolysin	269..464	CDD:279729	50/209 (24%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	50/207 (24%)
		Disintegrin	479..555	CDD:278623	34/75 (45%)
		ACR	558..701	CDD:214743	44/146 (30%)
ADAM29	NP_001124175.1	Pep_M12B_propep	32..150	CDD:307618	37/139 (27%)
		ZnMc_adamalysin_II_like	198..386	CDD:239797	49/194 (25%)
		Disintegrin	406..478	CDD:306668	34/74 (46%)
		ACR	483..618	CDD:214743	44/145 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	706..820		38/194 (20%)
		PAT1	<725..>819	CDD:330585	35/160 (22%)
		9 X 9 AA approximate repeats	739..819		29/111 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920