DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and ADAM30

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_068566.2	Gene:	ADAM30 / 11085	HGNCID:	208	Length:	790	Species:	Homo sapiens

Alignment Length:	799	Identity:	221/799 - (27%)
Similarity:	336/799 - (42%)	Gaps:	123/799 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LHLFLLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLL 68
            |.|.|:|.:||.:..:..|..|         ||          ||.:|.|..|:         .|
Human    13 LLLLLVPTMLLKSLGEDVIFHP---------EG----------EFDSYEVTIPE---------KL 49

  Fly    69 TTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEV 133
            :......|:.:| :|.....:||:.|:.|....||||     |:.........|.::........
Human    50 SFRGEVQGVVSP-VSYLLQLKGKKHVLHLWPKRLLLP-----RHLRVFSFTEHGELLEDHPYIPK 108

  Fly   134 DLCHYQGHIRGKPESVVALSTCDGALDGIV-IDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPT 197
            | |:|.|.::...:|...:|||.|.|.|:. ||.:. |.|.| :......:...||||:...  .
Human   109 D-CNYMGSVKESLDSKATISTCMGGLRGVFNIDAKH-YQIEP-LKASPSFEHVVYLLKKEQF--G 168

  Fly   198 NATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYN 262
            |..||.    .|...:::.|..:|                        |.|..|     ..|.|
Human   169 NQVCGL----SDDEIEWQMAPYEN------------------------KARLRD-----FPGSY- 199

  Fly   263 ANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEI 327
              |:..|:||:::.|...|:....|..:|......:..|::..:..:.:.:.|..:.:|.:.|:|
Human   200 --KHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKI 262

  Fly   328 -----EFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGV 387
                 |.:.    .|..|:.|:.:.|.....:|.|.|..:..:...:....  |.:|:.||:|.|
Human   263 RVGYPELAE----VLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSF--GKVCSLEYAGSV 321

  Fly   388 SMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDE-KCVMAASSTSFIPVNWSSCSIDQLTIA 451
            |.....|....||..|||:||..||.||...|.||.. .|:|.:..|.|     |:||.......
Human   322 STLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGF-----SNCSYISFFKH 381

  Fly   452 FSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGEC 516
            .|.|.. ||.|.|...:....|||..||..|:||||..|.|:...|....|.| ...|.|:.|.|
Human   382 ISSGAT-CLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKL-QPGANCSIGLC 444

  Fly   517 CDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQ 581
            |.  .||.:.:|..||:..|||||.|||.|.|..||.||:::|..||. .:..||...|||...|
Human   445 CH--DCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCK-YEGRCFRKGCRSRYMQ 506

  Fly   582 CRTLWGPTG-DNSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGM 644
            |::::||.. :....||:. |..|.:.|||....: :.|.:||..:..||.|.||::....:...
Human   507 CQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGI-RNFKKCESANSICGRLQCINVETIPDLPE 570

  Fly   645 ESAAVLSHSYISHDRKIVAC-----RTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAV 704
            .:..:.:|....:    :.|     ..::..:|:  .|.|:..:|..||..::|..:.|     |
Human   571 HTTIISTHLQAEN----LMCWGTGYHLSMKPMGI--PDLGMINDGTSCGEGRVCFKKNC-----V 624

  Fly   705 RQKGMGKPC-PEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVG-----F 763
            ....:...| ||.||..|:||:|.:|||..|:....|.:.|.|||.||||.....|::.     .
Human   625 NSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVV 689

  Fly   764 KRFLYVLFFFVLPVVALFW 782
            ...::.|...:|.||.:|:
Human   690 SIIMFRLILLILSVVFVFF 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	29/110 (26%)
		Reprolysin	269..464	CDD:279729	54/200 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	53/198 (27%)
		Disintegrin	479..555	CDD:278623	33/75 (44%)
		ACR	558..701	CDD:214743	37/149 (25%)
ADAM30	NP_068566.2	Pep_M12B_propep	60..159	CDD:279848	28/107 (26%)
		Cysteine switch. /evidence=ECO:0000250	170..177		2/10 (20%)
		Reprolysin	203..393	CDD:279729	54/201 (27%)
		ZnMc_adamalysin_II_like	203..391	CDD:239797	53/199 (27%)
		Disintegrin	408..481	CDD:278623	33/75 (44%)
		ACR	484..626	CDD:214743	38/154 (25%)
		cysteine-rich domain	494..679		57/196 (29%)
		transmembrane domain	680..705		4/24 (17%)
		cytoplasmic domain	706..790		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..790
		5 X 9 AA approximate repeats	732..776
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920