Protein Alignment Meltrin and ADAM28

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: NP_055080.2
• Gene: ADAM28 / 10863
• HGNCID: 206
• Length: 775
• Species: Homo sapiens
• Alignment Length: 975
• Identity: 282/975 - (28%)
• Similarity: 407/975 - (41%)
• Gaps: 239/975 - (24%)

  Fly     8 LLPL-LLLNTCL----------QQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHG 61
            |||: |||:..:          :..::.|......|:.|.::.:..   |:|.|
Human     5 LLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQ---EQFET----------- 55

  Fly    62 RTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVT 126
                               ::....|..||..|:.|::|..||...:...|.|::     |..:|
Human    56 -------------------ELKYKMTINGKIAVLYLKKNKNLLAPGYTETYYNST-----GKEIT 96

  Fly   127 TFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP----HIDGRGRLQDDHY 187
            |..:. :|.|:|||||..:..|..::|||.| |.|....|.|.|||.|    |.||:     :|.
Human    97 TSPQI-MDDCYYQGHILNEKVSDASISTCRG-LRGYFSQGDQRYFIEPLSPIHRDGQ-----EHA 154

  Fly   188 LLK-QADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQAD 251
            |.| ..|....::|||.|...  .:||.::       ...:|:..|         ..|:.|:
Human   155 LFKYNPDEKNYDSTCGMDGVL--WAHDLQQ-------NIALPATKL---------VKLKDRK--- 198

  Fly   252 DSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALV 316
                       ..::..|:|..:|:||..:|.:.||..::.:....:||.:|.||..||..||||
Human   199 -----------VQEHEKYIEYYLVLDNGEFKRYNENQDEIRKRVFEMANYVNMLYKKLNTHVALV 252

  Fly   317 GVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTY 381
            |:.||.:.::|:.:.:...||.||..:|.:.|.....:|.|||:|....||..||.|....:|:
Human   253 GMEIWTDKDKIKITPNASFTLENFSKWRGSVLSRRKRHDIAQLITATELAGTTVGLAFMSTMCS- 316

  Fly   382 EYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTSFIPVNWSSCSID 446
            .||.||...||.|...||.||||||||||||.||...|.|....|||..:.:.:||.::||||..
Human   317 PYSVGVVQDHSDNLLRVAGTMAHEMGHNFGMFHDDYSCKCPSTICVMDKALSFYIPTDFSSCSRL 381

  Fly   447 QLTIAFSRGMNYCLRNK--PERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNA 509
            .....|...::.||.|.  |..:..:|.|||..||.||.||||..|.|.|.||:|:||.:   .|
Human   382 SYDKFFEDKLSNCLFNAPLPTDIISTPICGNQLVEMGEDCDCGTSEECTNICCDAKTCKI---KA 443

  Fly   510 T--CATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFH 572
            |  ||.||||:  .|:.|.||..||.|::||||||.|.|:|..||.|.|:.:..||..|:.:|..
Human   444 TFQCALGECCE--KCQFKKAGMVCRPAKDECDLPEMCNGKSGNCPDDRFQVNGFPCHHGKGHCLM 506

  Fly   573 GTCRSHSNQCRTLWGP---TGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCI 634
            |||.:...||..||||   ..|.|  |||:|..|::.|.|  .|::.|.:.|:.....||.|.|.
Human   507 GTCPTLQEQCTELWGPGTEVADKS--CYNRNEGGSKYGYC--RRVDDTLIPCKANDTMCGKLFCQ 567

  Fly   635 HLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDP-------GLTPNGAKCGVDKM 692
            ..::.|.:               ..:||...|.      :|.||       |:..||.|||.:|:
Human   568 GGSDNLPW---------------KGRIVTFLTC------KTFDPEDTSQEIGMVANGTKCGDNKV 611

  Fly   693 CVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDP 757
            |::..|:.::...:   ...|...|.|:.:|:....|.|:.|:....|.        ||.
Human   612 CINAECVDIEKAYK---STNCSSKCKGHAVCDHELQCQCEEGWIPPDCD--------DSS----- 660

  Fly   758 NGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTG 822
                       |:|.|.:.|..||..........|:.|.:.:..  |.....:|::|    .||
Human   661 -----------VVFHFSIVVGVLFPMAVIFVVVAMVIRHQSSRE--KQKKDQRPLST----TGT- 707

  Fly   823 PPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFV 887
                                                        ||......|..      |..|
Human   708 --------------------------------------------RPHKQKRKPQM------VKAV 722

  Fly   888 QPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALPP----PNPGSTARPIISPPK 948
            |       ||.|:.    :||....:.....:|.|::.:...||||    .||.||  |..|.||
Human   723 Q-------PQEMSQ----MKPHVYDLPVEGNEPPASFHKDTNALPPTVFKDNPVST--PKDSNPK 774

  Fly   949  948
            Human   775  774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	32/120 (27%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	77/192 (40%)
		Disintegrin	479..554	CDD:459709	41/76 (54%)
		ACR	558..701	CDD:214743	45/152 (30%)
		PHA03247	<823..1261	CDD:223021	25/130 (19%)
		PHA03247	<1220..1392	CDD:223021
ADAM28	NP_055080.2	Pep_M12B_propep	29..156	CDD:460254	43/171 (25%)
		Cysteine switch. /evidence=ECO:0000250	167..174		4/6 (67%)
		ZnMc_adamalysin_II_like	204..397	CDD:239797	77/193 (40%)
		Disintegrin	416..488	CDD:459709	41/76 (54%)
		ACR	493..620	CDD:214743	45/151 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	690..775		30/155 (19%)