DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and LOC101884782

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_021334457.1	Gene:	LOC101884782 / 101884782	-ID:	-	Length:	760	Species:	Danio rerio

Alignment Length:	783	Identity:	237/783 - (30%)
Similarity:	343/783 - (43%)	Gaps:	109/783 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLNTCLQQHILQPAEATAFH-------------QSEGEKSKAHPVLEEFSTYTVIRPQVEHGR 62
            ||||..||    |.||.|.|..             .|.|.:...|.:  .:.:..:.........
Zfish     9 LLLLICCL----LPPAAAAAAELLQNDDPASGQQLNSSGPQDTQHTL--SYPSRLIYYLHENSES 67

  Fly    63 TKRSLLTTLDATD----GLHTPQISLSYTHEGKRVVVDLQ-RNDLLLPNSHFLRYQNASRGATPG 122
            |...|.|....||    ..|..|.|......|.:.::||. .||||..:...:.|:........|
Zfish    68 TYHDLNTHAKTTDPRAQEAHLAQTSFQLQAFGSQFILDLTLNNDLLSSDYVEIHYEEEKPVLWKG 132

  Fly   123 HVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHY 187
            .          :.|:|.|.|||..:|.||||||:| |.|:..||...|.|.|       |...|.
Zfish   133 G----------EHCYYHGQIRGVEDSRVALSTCNG-LHGMFDDGVHLYTIEP-------LNQTHT 179

  Fly   188 LLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADD 252
            :...|..|..        ||.|....              ||  .|.:|.|...:.||:|::
Zfish   180 IEGTARAHVL--------HRTDLQQS--------------PS--AREEGMEEDFSWLRRRKK--- 217

  Fly   253 SSQLIRG-PYNANKYSSYVELVIVVDNKVYKNFQENTKK-VHQYCKGIANIINALYVP-LNIFVA 314
                 |. |.|..:...|:||:||:|:.::|..:  ||: .....|.:.|:::|::.. ||..|.
Zfish   218 -----RAIPRNVFEEMKYIELMIVIDHNMFKRLK--TKQHTRNNAKSVVNLVDAIFKEHLNTRVV 275

  Fly   315 LVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPIC 379
            ||.|.||.:.:.|..|......||||..||. :.:..|. |..||.:...|.......|..|.:|
Zfish   276 LVAVEIWTDKDRIPVSVTPFEMLRNFSKYRQ-QHIRQHA-DTVQLFSNVTFHYPRSSAAYFGGMC 338

  Fly   380 TYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTS----DCHCRDE--KCVMAASSTSFIPV 438
            :..:..|| :::.....| |..::..:..|.|::.|::    ||.|.:.  .|:|..:.... |.
Zfish   339 SASHGVGV-IEYGTQWTM-ALQLSQSLAQNLGIQWDSASKRKDCGCVNSWPGCIMEDTGVQH-PR 400

  Fly   439 NWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCM 503
            .:|.|||........:|...||.|||.:|||...||||:||.||:||||..:.|...||  :.|.
Zfish   401 AFSKCSIVSFKEFLLKGGGSCLFNKPSKLFEDTECGNGYVEVGEECDCGPRDECYKDCC--KKCS 463

  Fly   504 LHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQA 568
            | |..|.|:.|.||: .||.....|..||.|.|:||:.|.|||:|..||.::.::|...|...|.
Zfish   464 L-SNGAHCSDGPCCN-NTCLFYSRGHTCRYAVNDCDISETCTGDSGLCPPNLHKQDGYFCSLNQG 526

  Fly   569 YCFHGTCRSHSNQCRTLWGPTGDNSE-HCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGML 631
            .|:.|.|::..:||:.:|||...:|| .||.| ||||:..||||.:  ...:.:|.:..|.||.|
Zfish   527 RCYAGECKTRDSQCKYVWGPKAASSEKFCYEKLNTEGSEKGNCGPD--GDKWTQCSKHDVFCGFL 589

  Fly   632 HCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQ 696
            .|.:.......|:....:...:: :|..:::.|..|.|.|..| ||.|...:|..||...||||:
Zfish   590 LCTNTGRIPRIGIIKGEITPTNF-NHQGRLIDCSGAHVLLDDQ-TDVGYVEDGTPCGPSMMCVDR 652

  Fly   697 RCLPVDAVRQKGMGKPCPED-----CNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATD 756
            :|||:..:....    ||..     |:.:|:||:...|.||..:.|..||.|.....|:......
Zfish   653 KCLPIQYLNLSS----CPNGPNGHVCSSHGVCNNEATCTCDTTWAGMDCSLADPPKEPEPDEDEG 713

  Fly   757 PNG 759
            |.|
Zfish   714 PKG 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	36/114 (32%)
		Reprolysin	269..464	CDD:279729	57/202 (28%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	56/200 (28%)
		Disintegrin	479..555	CDD:278623	34/75 (45%)
		ACR	558..701	CDD:214743	49/144 (34%)
LOC101884782	XP_021334457.1	Pep_M12B_propep	83..189	CDD:307618	37/123 (30%)
		Reprolysin	229..426	CDD:330960	57/203 (28%)
		Disintegrin	441..512	CDD:306668	34/74 (46%)
		ACR	516..657	CDD:214743	49/144 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010