DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam12

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_021336100.1	Gene:	adam12 / 101884222	-ID:	-	Length:	668	Species:	Danio rerio

Alignment Length:	655	Identity:	224/655 - (34%)
Similarity:	328/655 - (50%)	Gaps:	77/655 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YTVIRPQVEHGRTKR--SLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPN----SHF 109
            |.||.|.:..|..:|  |.:.:|.     |...:.:.....|:::::.|.:|:.|..:    :|:
Zfish    47 YEVIEPYLLIGGQQRPVSHIKSLG-----HPASLKVLIKVNGEQLLLALWKNEGLFASHYTETHY 106

  Fly   110 LRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP 174
            |.         .|..|||.....:. |:|.|.:.|...|.|.:|||.| |.|::....:.|.:.|
Zfish   107 LE---------DGVAVTTLPNVTIH-CYYHGEVMGHQGSDVTISTCTG-LRGLISLEDEVYVLEP 160

  Fly   175 HIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRL-DGGE 238
            ..:|     :.|.|.:...:..|..|||       |.|:.              |.|..: :...
Zfish   161 TQEG-----NTHRLYRGQHLKLTQGTCG-------HGHNI--------------SQPAEMFNTAV 199

  Fly   239 FSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIIN 303
            ||....|.:|.|..|::             :|||:||.||:.|:...::.:||.|....|||.::
Zfish   200 FSSHSARHKRDAQSSTK-------------HVELIIVADNREYQKQGKDVEKVKQRLAEIANYVD 251

  Fly   304 ALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGG 368
            ..|..|||.|||||:.:|::.::...:.|...:|..||::|..||:....:|||||::...|.|.
Zfish   252 KFYRSLNIRVALVGLEVWSDGDKCSITQDPFTSLHEFLDWRKLKLLPLRAHDNAQLISGVYFQGT 316

  Fly   369 VVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSD--CHCRDE----KCV 427
            .:|.|....:||.|.|||:.|.||.||...|.|:|||:||||||.|||.:  |.||..    .|:
Zfish   317 TIGMAPIMSMCTAEQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTPERGCGCRATVDRGGCI 381

  Fly   428 MAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPE--RLFESPTCGNGFVEPGEQCDCGLPE 490
            |..|:....|..:|:||...|..:..:|:..||.|.||  .|:....||||:||.|||||||..|
Zfish   382 MTPSTGYPFPTVFSTCSKKDLAASLEKGVGMCLFNMPEVKVLYGGQKCGNGYVEEGEQCDCGDLE 446

  Fly   491 HCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADV 555
            .|.|.||||.||.| .:.|.||.|:||:  .|:.|.||:.|||:.|.|||||:|||...:|||:|
Zfish   447 ECLNPCCNASTCTL-KEEAVCAHGQCCE--NCQLKPAGTPCRESSNSCDLPEFCTGADPHCPANV 508

  Fly   556 FRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTF 618
            :..|...|.|...:|::|.|::|..||.||||.....:.. |:.: |:.|...||||.: ...:|
Zfish   509 YLHDGHSCQGVDGHCYNGICQTHEQQCITLWGQGAKPAPGICFERVNSAGDPYGNCGKD-TKGSF 572

  Fly   619 LRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPN 683
            .:||.:...||.:.|.....|...|..:.::.::..:....:|: ||...|.||....||||...
Zfish   573 AKCEARDAKCGKIQCQGGANRPVIGTNAVSIETNIPLQEGGRIL-CRGTHVYLGDDMPDPGLVLT 636

  Fly   684 GAKCG 688
            |.|||
Zfish   637 GTKCG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	27/115 (23%)
		Reprolysin	269..464	CDD:279729	80/200 (40%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	79/198 (40%)
		Disintegrin	479..555	CDD:278623	43/75 (57%)
		ACR	558..701	CDD:214743	42/133 (32%)
adam12	XP_021336100.1	Pep_M12B_propep	48..170	CDD:307618	34/142 (24%)
		Reprolysin	216..418	CDD:307535	80/214 (37%)
		DISIN	435..509	CDD:214490	43/76 (57%)
		ACR	512..645	CDD:214743	42/132 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010