Protein Alignment Meltrin and adam12a

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_073775007.1
• Gene: adam12a / 101884222
• ZFINID: ZDB-GENE-201117-1
• Length: 937
• Species: Danio rerio
• Alignment Length: 955
• Identity: 304/955 - (31%)
• Similarity: 452/955 - (47%)
• Gaps: 131/955 - (13%)

  Fly    51 YTVIRPQVEHGRTKR--SLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPN----SHF 109
            |.||.|.:..|..:|  |.:.:|.     |...:.:.....|:::::.|.:|:.|..:    :|:
Zfish    47 YEVIEPYLLIGGQQRPVSHIKSLG-----HPASLKVLIKVNGEQLLLALWKNEGLFASHYTETHY 106

  Fly   110 LRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHP 174
            |.         .|..|||.....:. |:|.|.:.|...|.|.:|||.| |.|::....:.|.:.|
Zfish   107 LE---------DGVAVTTLPNVTIH-CYYHGEVMGHQGSDVTISTCTG-LRGLISLEDEVYVLEP 160

  Fly   175 HIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRL-DGGE 238
            ..:|     :.|.|.:...:..|..|||       |.|:.              |.|..: :...
Zfish   161 TQEG-----NTHRLYRGQHLKLTQGTCG-------HGHNI--------------SQPAEMFNTAV 199

  Fly   239 FSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIIN 303
            ||....|.:|.|..|::             :|||:||.||:.|:...::.:||.|....|||.::
Zfish   200 FSSHSARHKRDAQSSTK-------------HVELIIVADNREYQKQGKDVEKVKQRLAEIANYVD 251

  Fly   304 ALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGG 368
            ..|..|||.|||||:.:|::.::...:.|...:|..||::|..||:....:|||||::...|.|.
Zfish   252 KFYRSLNIRVALVGLEVWSDGDKCSITQDPFTSLHEFLDWRKLKLLPLRAHDNAQLISGVYFQGT 316

  Fly   369 VVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSD--CHCRDE----KCV 427
            .:|.|....:||.|.|||:.|.||.||...|.|:|||:||||||.|||.:  |.||..    .|:
Zfish   317 TIGMAPIMSMCTAEQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTPERGCGCRATVDRGGCI 381

  Fly   428 MAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPE--RLFESPTCGNGFVEPGEQCDCGLPE 490
            |..|:....|..:|:||...|..:..:|:..||.|.||  .|:....||||:||.|||||||..|
Zfish   382 MTPSTGYPFPTVFSTCSKKDLAASLEKGVGMCLFNMPEVKVLYGGQKCGNGYVEEGEQCDCGDLE 446

  Fly   491 HCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADV 555
            .|.|.||||.||.| .:.|.||.|:||:  .|:.|.||:.|||:.|.|||||:|||...:|||:|
Zfish   447 ECLNPCCNASTCTL-KEEAVCAHGQCCE--NCQLKPAGTPCRESSNSCDLPEFCTGADPHCPANV 508

  Fly   556 FRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEH-CYNK-NTEGTRLGNCGYNRLNKTF 618
            :..|...|.|...:|::|.|::|..||.||||.....:.. |:.: |:.|...||||.: ...:|
Zfish   509 YLHDGHSCQGVDGHCYNGICQTHEQQCITLWGQGAKPAPGICFERVNSAGDPYGNCGKD-TKGSF 572

  Fly   619 LRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPN 683
            .:||.:...||.:.|.....|...|..:.::.::..:....:|: ||...|.||....||||...
Zfish   573 AKCEARDAKCGKIQCQGGANRPVIGTNAVSIETNIPLQEGGRIL-CRGTHVYLGDDMPDPGLVLT 636

  Fly   684 GAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGS 748
            |.|||.:.||::::|..:..:   |: ..|...|:|:|:||:..:|||:..:....|.|.|.|||
Zfish   637 GTKCGQNMMCINRQCQNISVL---GV-HDCSAKCSGHGVCNNNKNCHCEAQWAPPFCDKTGFGGS 697

  Fly   749 PDSGP--ATDPNG-SVG-FKRFLYVLFFFVLPVV---ALFWFLYHCYKNGMLTRGKLADNILKS- 805
            .||||  .||.:. :|| ...||.::...::..:   .|....:...||.:.....:..:.|.|
Zfish   698 LDSGPMRPTDSSSVTVGILVAFLCLVCVGIIACIKRKTLLSLFFSNKKNTIEKLRSVGPHRLNSP 762

  Fly   806 ----SGGSKPITTRTNQNG-TGPPPSNGLLKSTPSSTDDMDSALLKSPSDS------TPSAGLFG 859
                |......|.||:..| |...|....:..|.|....:||.|   ||.|      .|:..|..
Zfish   763 AHTVSSNQTHSTYRTSPQGHTAASPQTASIYQTRSPLQPVDSVL---PSHSLRRLPQCPALHLSH 824

  Fly   860 KFDGFTLRPLNDASSP----------ASNYNGP---NV-----AFVQPTVQQDGPQRMAPPPPVV 906
            ........|....::|          |.:..||   ||     ||.:|:    .||:..|..|:.
Zfish   825 PLTTTQTHPSPARAAPHTYTHTPAPAAPSTRGPACHNVCRIAMAFEKPS----PPQKPLPADPLG 885

  Fly   907 KPGTAP--IHPPSPKPEATWVRPA---PALPPP-NPGSTARPIIS 945
            :....|  |..|:|.|:....|||   |..||| :|.:..:|.:|
Zfish   886 RLMRNPSNIRLPAPVPKPAVPRPAPPQPCRPPPRHPATLPKPHLS 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	31/126 (25%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	79/198 (40%)
		Disintegrin	479..554	CDD:459709	42/74 (57%)
		ACR	558..701	CDD:214743	45/144 (31%)
		PHA03247	<823..1261	CDD:223021	40/153 (26%)
		PHA03247	<1220..1392	CDD:223021
adam12a	XP_073775007.1	None