DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and adam28.4

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_031754080.1	Gene:	adam28.4 / 101735040	XenbaseID:	XB-GENE-22167138	Length:	819	Species:	Xenopus tropicalis

Alignment Length:	796	Identity:	233/796 - (29%)
Similarity:	353/796 - (44%)	Gaps:	155/796 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLHLHLFLLPLLLLNTCLQQHILQPAEATAFHQS--EGEKSKAHPVLEEFSTYTVIRPQVEHG-- 61
            :|.|..:.||.......:...|||..|..||..:  ||.:...|            .|....|
Frog    16 VLVLQGWALPATQKYEIVYPQILQAQENQAFTSAPLEGHRPGLH------------HPHPPKGFT 68

  Fly    62 ----RTKRSLLTTLDATDGLHTPQISLSYTH----------EGKRVVVDLQR-NDLLLPNSHFLR 111
                |.:|         .|:| |:....:.|          :.|.:|:.|:: .||...:....|
Frog    69 FGPPRNRR---------PGVH-PRHPPKHRHPRMLQYELQLDNKPLVLHLEKTEDLFFRDYTETR 123

  Fly   112 YQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHI 176
            |   .:..||    ||.:....|.|:|||.:...|:|:|:||||:| |.||:....:.:.|.| :
Frog   124 Y---LQDGTP----TTISPVIKDHCYYQGRVMNDPDSLVSLSTCNG-LRGIITTKGRHFLIEP-L 179

  Fly   177 DGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSR 241
            ......:...|..:..::.||:....|:|..:|                            ||
Frog   180 SASDSEEHALYPYEPQEVSPTSCGVTYNNGGED----------------------------EF-- 214

  Fly   242 TLLRKRRQ--ADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINA 304
               ||...  |:...:::|.       ..||:|.:|.||.:|..:..:.:.:.|....:.|.:|.
Frog   215 ---RKMSSSFANQEDKILRS-------KKYVQLYVVADNSMYLKYNGSKETIKQRIYEMVNYVNM 269

  Fly   305 LYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGV 369
            :|.|||:|.||.|:.||::.::|...::..:.|..|..:|...|:....||.|||:|..||.|.|
Frog   270 VYKPLNVFAALCGIEIWDQGDQIAMLTNSKVNLARFSAWREKVLLPRKQNDLAQLITNINFDGPV 334

  Fly   370 VGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASSTS 434
            ||.|..|.||:...|.||...|:....::..|.||||||:.||.||...|.|....|:|:...:|
Frog   335 VGIAYIGMICSTTQSAGVLQDHNKLSIILGATSAHEMGHSLGMYHDGKACACNKVYCLMSTKLSS 399

  Fly   435 FIPVNWSSCSIDQLTIAFSRGMNYCLRNKPER--LFESPTCGNGFVEPGEQCDCGLPEHCENACC 497
            ::|..:|:|||:............||.:.|::  :...|.|||.|.|.||.||||..:.|::.||
Frog   400 WVPNTFSTCSINNFQEFLLNTRPTCLGDIPDKTNILTPPVCGNKFTEMGEDCDCGTVQECKDQCC 464

  Fly   498 NAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEP 562
            :|.||.| ...|.||.||||  :.|:.|.||..|||..::|||.:.|.|.|.:||:|.|:.:..|
Frog   465 DAATCKL-KPGAQCAEGECC--SNCKIKAAGEVCRERNDDCDLEDVCDGTSPWCPSDRFQANGAP 526

  Fly   563 CDGGQAYCFHGTCRSHSNQCRTLWGP-TGDNSEHCYNKNTEGTRLGNCGYNRLNKTFLRCEEQHV 626
            |..|:.||::|||.:...||.:|||. |....:.|:|||.|||..|:|  ..:..|::.|:.::|
Frog   527 CGKGEGYCYNGTCPTMQRQCTSLWGENTLVGEDLCFNKNMEGTDYGHC--KNVGSTYIPCKPENV 589

  Fly   627 NCGMLHCIHLNE------RLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTPNGA 685
            .||:|:|...|:      |:....|..|:|:                         ..|:..||.
Frog   590 MCGVLYCNSDNKYPTVPGRVAVTGECKALLA-------------------------PEGMVQNGI 629

  Fly   686 KCGVDKMCVDQRCLPVD-AVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGE-------SCSK 742
            |||..|:|.:..|:.|: |....|    |...|:|||:.:            ||       :...
Frog   630 KCGDGKVCYNNECVSVETAFGLSG----CEGKCSGNGVTH------------GEIMQEFLLNTQP 678

  Fly   743 AGSGGSPDSGPATDPN 758
            :..|..||......||
Frog   679 SSLGDVPDKTNFLRPN 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	33/120 (28%)
		Reprolysin	269..464	CDD:279729	68/194 (35%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	68/192 (35%)
		Disintegrin	479..555	CDD:278623	36/75 (48%)
		ACR	558..701	CDD:214743	44/149 (30%)
adam28.4	XP_031754080.1	Pep_M12B_propep	79..190	CDD:396235	32/120 (27%)
		ZnMc_adamalysin_II_like	233..425	CDD:239797	66/191 (35%)
		DISIN	446..520	CDD:214490	37/76 (49%)
		ACR	522..645	CDD:214743	44/149 (30%)
		Disintegrin	702..775	CDD:395147
		ADAM_CR	779..>808	CDD:417715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920