DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam28.3

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_031755156.1	Gene:	adam28.3 / 100498252	XenbaseID:	XB-GENE-22167131	Length:	674	Species:	Xenopus tropicalis

Alignment Length:	715	Identity:	217/715 - (30%)
Similarity:	337/715 - (47%)	Gaps:	111/715 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHF-LRYQN 114
            |.::.||..|.:.||.       |..::...:......|.:.:|:.|::.:.|:.|... .|||.
Frog    30 YEIVIPQKLHSQYKRD-------TQSMYPDVVQYEVLLENRPLVLHLEKTEGLIHNDFTETRYQQ 87

  Fly   115 ASRGATPGHVVTTFTKTEV-DLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDG 178
            ..        :.|..:.|| |||.|||.::|.|.|:|:||||:| |.|.::....|:.|.|
Frog    88 DG--------MRTTNRPEVKDLCLYQGQVKGDPHSLVSLSTCNG-LSGSIMTQGHTFLIEP---- 139

  Fly   179 RGRLQDDHYLLKQADMHPTNATCGYDNHRDDHS-HDYE-KADGDNGLGGGIPSLPLRLDGGEF-- 239
                      ||:.|             .::|: ::|: |||.....|....::|    .|||
Frog   140 ----------LKETD-------------SEEHAFYEYDPKADTSKACGVTSSNMP----EGEFNT 177

  Fly   240 -SRTL-LRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYCKGIANII 302
             |.|: |.::::..:||:             ||:|.:|.|..:.:.:..:.:.:......:.|..
Frog   178 ASYTMDLTEKQEILNSSK-------------YVQLYVVADYSMVQKYNGSVETIKNRIFQMMNYN 229

  Fly   303 NALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAG 367
            |.:|..||:|:||.||..|...::....|..:..|.||..:|...||....:|.|..||...|..
Frog   230 NMVYKALNVFIALCGVEFWENGDQFPVPSPANECLGNFSEWRDKNLVPRKLHDAAVFLTNVKFVA 294

  Fly   368 GVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHCRDEKCVMAASS 432
            .:||.|..|.:|...:|.||...:|....:||:.:|||:||||||.||::||.|....|:|:...
Frog   295 PLVGLAYVGGMCFGRFSAGVINDYSKEATIVASIIAHEVGHNFGMNHDSTDCSCSSASCIMSKYV 359

  Fly   433 TSFIPVNWSSCSIDQLTIAFSRGMNY-------CLRNKPER--LFESPTCGNGFVEPGEQCDCGL 488
            :...|..:|:|||.    ||   .|:       |:.:.|::  :...|.|||.|.|.||.||||.
Frog   360 SPVAPTLFSNCSIS----AF---QNFLLTKNPTCISDIPDKPDILTPPVCGNKFTEVGEDCDCGT 417

  Fly   489 PEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPA 553
            .:.|:|.||:|.||. ...|..|..|||||  .|..|.||..||.::.:|||.:.|.|.|..||:
Frog   418 VQECKNPCCDAATCK-KKPNVQCTGGECCD--NCMIKAAGHVCRASKGDCDLDDLCNGVSSSCPS 479

  Fly   554 DVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWG-PTGDNSEHCYNKNTEGTRLGNCGYNRLNKT 617
            |.||.:..||:.|:.||::|:|.:..|||..:|| .:..:...|:|.||.|...|:|..|  ..|
Frog   480 DRFRVNGLPCNNGRGYCYNGSCPTMLNQCNAIWGVDSAVSGNSCFNMNTNGVIYGHCKQN--GTT 542

  Fly   618 FLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLTP 682
            ::.|..:.:.||:|.||:   ...|.:.||..::         ..||:..|       :..|...
Frog   543 YVPCAAEDIMCGVLFCIN---GTTFPLISAPFVT---------TPACKALL-------SPAGKVQ 588

  Fly   683 NGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGG 747
            :|||||..|:|.:.:|:..:.......|  |...|..|.:|:....|.|..|:...:|:.|.:.|
Frog   589 SGAKCGNGKVCSNNQCVTTETAYIGSSG--CDSKCPKNAVCDHELICQCTKGWVPPNCNVAVTSG 651

Fly 748 747
Frog 652 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	33/111 (30%)
		Reprolysin	269..464	CDD:279729	64/201 (32%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	64/199 (32%)
		Disintegrin	479..555	CDD:278623	35/75 (47%)
		ACR	558..701	CDD:214743	42/143 (29%)
adam28.3	XP_031755156.1	Pep_M12B_propep	31..150	CDD:396235	41/161 (25%)
		ZnMc_adamalysin_II_like	195..389	CDD:239797	64/213 (30%)
		DISIN	408..482	CDD:214490	36/76 (47%)
		ACR	485..605	CDD:214743	41/140 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010