Protein Alignment Meltrin and adam22

DIOPT Version :10

• Sequence 1: NP_001027575.1
• Gene: Meltrin / 3772109
• FlyBaseID: FBgn0265140
• Length: 1407
• Species: Drosophila melanogaster
• Sequence 2: XP_031759145.1
• Gene: adam22 / 100494669
• XenbaseID: XB-GENE-957019
• Length: 936
• Species: Xenopus tropicalis
• Alignment Length: 969
• Identity: 270/969 - (27%)
• Similarity: 408/969 - (42%)
• Gaps: 162/969 - (16%)

  Fly    57 QVEHGRTKRSLLTTLDATDGLHTPQISLSYTHE----------GKRVVVDLQRNDLLLPNSHFLR 111
            :|::..|:..|.|.:.|....|..|:    ||.          |...::|::.|..||.:.:..|
 Frog    60 EVDNQTTQGLLSTRVRAGSPQHQDQL----THVARASFQIDAFGSSFILDVELNHDLLSSEYRER 120

  Fly   112 YQNASRGATPGHVVTTFTKTEVDL-----CHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYF 171
            :            ||...|| |:.     |:|||.||||.:|.||||||.| |.|:..||..||.
 Frog   121 H------------VTQDGKT-VEFKGGEHCYYQGQIRGKAKSFVALSTCYG-LHGMFCDGNHTYL 171

  Fly   172 IHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDG 236
            |.|     |.                    .|:.:.|...|...|:   ..|...|..||
 Frog   172 IEP-----GE--------------------KYNPNEDYQFHSVYKS---KVLEFPIDELP----- 203

  Fly   237 GEF------SRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYC 295
            .||      |..|.::.|......|..|.|.|....:.||||:||.|:.:||..:.:....:.|.
 Frog   204 SEFWPLNDTSPRLSQQTRNQRKKRQTRRYPRNVEDETKYVELMIVNDHLMYKKHRLSVGHTNSYA 268

  Fly   296 KGIANIINALY-VPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQL 359
            |.:.|:.:.:| ..||..:.||.:..|...|:...|.:..|||:.|:.||  :..:...:|...|
 Frog   269 KSVVNMADLIYKEQLNTRIVLVAMETWATDNKFSISENPLLTLKEFMKYR--RDFIKDKSDAVHL 331

  Fly   360 LTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHD-----TSDC 419
            .:...|.....|.|..|.:|:....|||:  ....|.::|.|:|..:.||.|:..|     :.:|
 Frog   332 FSGSQFESSRSGAAYIGGVCSLLKGGGVN--EFGKPDVMAVTLAQSLAHNLGIFSDKKKLLSGEC 394

  Fly   420 HCRD--EKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGE 482
            .|.|  ..|:| .....::|..:|.|:|::.....:.|...||.|||.:|.:.|.|||||||.||
 Frog   395 KCEDTWSGCIM-GDIGYYLPSKFSVCNIEEYHEFLNNGGGSCLFNKPLKLLDPPECGNGFVEAGE 458

  Fly   483 QCDCGLPEHCE---NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYC 544
            :||||....|.   ..||  :.|.| ::::.|:.|.||......||  ...||||.|:||:||.|
 Frog   459 ECDCGTIAECAVEGGECC--KKCTL-TQDSECSDGLCCSDCKFNPK--EMICREAVNDCDIPETC 518

  Fly   545 TGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWG-PTGDNSEHCYNK-NTEGTRLG 607
            ||.|..|||::.:.|...|:..|..||.|.|::...||:.:|| ......::||.| |.|||..|
 Frog   519 TGNSSQCPANIHKLDGYQCESMQGLCFGGRCKTRERQCKYIWGEKVSAADKYCYEKLNIEGTEKG 583

  Fly   608 NCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLG 672
            |||.|:  :|:::|.:|.|.||.|.|.:::.....|.....|.:.|.::.. |:..|....|.|.
 Frog   584 NCGRNK--ETWIQCNKQDVLCGYLLCTNISSVPRLGELDGDVTTSSVVNQG-KLYNCSGGHVKLD 645

  Fly   673 LQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGG 737
             :.||.|...:|..||...||::.||||:|:...........:.|:|:|:|::...|.||..:.|
 Frog   646 -EDTDLGYVEDGTPCGTGMMCLEHRCLPIDSFNFSTCLGSTNKICSGHGVCSNEVKCICDSFWTG 709

  Fly   738 ESCSK--------AGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLT 794
            :.||.        ....|..|.| ....|..:|......::...||.:.|  |    .|||....
 Frog   710 DDCSNFLPYDGIIKPDEGHRDEG-VISTNIIIGAIAGTILVLALVLGITA--W----GYKNYRRE 767

  Fly   795 RGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALL---KSPSDSTPSAG 856
            |.....:.:|..|.:....:..       ||.   :.|..:|:....||:|   :..:.|.|...
 Frog   768 RQIPQGDYVKKPGDADSFYSDL-------PPG---VSSNSASSSKKRSAILSHFQISACSIPHYS 822

  Fly   857 LFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPE 921
            :......|..|  ::..|.:.:...|:...|....:...|:                       .
 Frog   823 ISQNISLFCRR--SNGLSHSWSERIPDTKHVSDVCENGRPR-----------------------S 862

  Fly   922 ATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLK---DSTEDLSPSRSAP-PVP 976
            .:|.....:......|...||      ..:||.|:.|.|   .||..::.||..| |:|
 Frog   863 NSWQGNVSSSRKKLRGKRFRP------RSNSTETLSPAKSPSSSTGSIASSRKYPYPMP 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	53..174	CDD:460254	43/131 (33%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	56/200 (28%)
		Disintegrin	479..554	CDD:459709	33/77 (43%)
		ACR	558..701	CDD:214743	49/144 (34%)
		PHA03247	<823..1261	CDD:223021	31/161 (19%)
		PHA03247	<1220..1392	CDD:223021
adam22	XP_031759145.1	Pep_M12B_propep	82..190	CDD:460254	42/150 (28%)
		Reprolysin	241..440	CDD:426256	57/203 (28%)
		Disintegrin	455..528	CDD:459709	33/77 (43%)
		ACR	532..673	CDD:214743	49/144 (34%)
		EGF_2	688..712	CDD:400365	8/23 (35%)