DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and adam22

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_031759145.1	Gene:	adam22 / 100494669	XenbaseID:	XB-GENE-957019	Length:	936	Species:	Xenopus tropicalis

Alignment Length:	969	Identity:	270/969 - (27%)
Similarity:	408/969 - (42%)	Gaps:	162/969 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QVEHGRTKRSLLTTLDATDGLHTPQISLSYTHE----------GKRVVVDLQRNDLLLPNSHFLR 111
            :|::..|:..|.|.:.|....|..|:    ||.          |...::|::.|..||.:.:..|
Frog    60 EVDNQTTQGLLSTRVRAGSPQHQDQL----THVARASFQIDAFGSSFILDVELNHDLLSSEYRER 120

  Fly   112 YQNASRGATPGHVVTTFTKTEVDL-----CHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYF 171
            :            ||...|| |:.     |:|||.||||.:|.||||||.| |.|:..||..||.
Frog   121 H------------VTQDGKT-VEFKGGEHCYYQGQIRGKAKSFVALSTCYG-LHGMFCDGNHTYL 171

  Fly   172 IHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDG 236
            |.|     |.                    .|:.:.|...|...|:   ..|...|..||
Frog   172 IEP-----GE--------------------KYNPNEDYQFHSVYKS---KVLEFPIDELP----- 203

  Fly   237 GEF------SRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVHQYC 295
            .||      |..|.::.|......|..|.|.|....:.||||:||.|:.:||..:.:....:.|.
Frog   204 SEFWPLNDTSPRLSQQTRNQRKKRQTRRYPRNVEDETKYVELMIVNDHLMYKKHRLSVGHTNSYA 268

  Fly   296 KGIANIINALY-VPLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQL 359
            |.:.|:.:.:| ..||..:.||.:..|...|:...|.:..|||:.|:.||  :..:...:|...|
Frog   269 KSVVNMADLIYKEQLNTRIVLVAMETWATDNKFSISENPLLTLKEFMKYR--RDFIKDKSDAVHL 331

  Fly   360 LTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGMEHD-----TSDC 419
            .:...|.....|.|..|.:|:....|||:  ....|.::|.|:|..:.||.|:..|     :.:|
Frog   332 FSGSQFESSRSGAAYIGGVCSLLKGGGVN--EFGKPDVMAVTLAQSLAHNLGIFSDKKKLLSGEC 394

  Fly   420 HCRD--EKCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGE 482
            .|.|  ..|:| .....::|..:|.|:|::.....:.|...||.|||.:|.:.|.|||||||.||
Frog   395 KCEDTWSGCIM-GDIGYYLPSKFSVCNIEEYHEFLNNGGGSCLFNKPLKLLDPPECGNGFVEAGE 458

  Fly   483 QCDCGLPEHCE---NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECDLPEYC 544
            :||||....|.   ..||  :.|.| ::::.|:.|.||......||  ...||||.|:||:||.|
Frog   459 ECDCGTIAECAVEGGECC--KKCTL-TQDSECSDGLCCSDCKFNPK--EMICREAVNDCDIPETC 518

  Fly   545 TGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWG-PTGDNSEHCYNK-NTEGTRLG 607
            ||.|..|||::.:.|...|:..|..||.|.|::...||:.:|| ......::||.| |.|||..|
Frog   519 TGNSSQCPANIHKLDGYQCESMQGLCFGGRCKTRERQCKYIWGEKVSAADKYCYEKLNIEGTEKG 583

  Fly   608 NCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLG 672
            |||.|:  :|:::|.:|.|.||.|.|.:::.....|.....|.:.|.::.. |:..|....|.|.
Frog   584 NCGRNK--ETWIQCNKQDVLCGYLLCTNISSVPRLGELDGDVTTSSVVNQG-KLYNCSGGHVKLD 645

  Fly   673 LQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGG 737
             :.||.|...:|..||...||::.||||:|:...........:.|:|:|:|::...|.||..:.|
Frog   646 -EDTDLGYVEDGTPCGTGMMCLEHRCLPIDSFNFSTCLGSTNKICSGHGVCSNEVKCICDSFWTG 709

  Fly   738 ESCSK--------AGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFWFLYHCYKNGMLT 794
            :.||.        ....|..|.| ....|..:|......::...||.:.|  |    .|||....
Frog   710 DDCSNFLPYDGIIKPDEGHRDEG-VISTNIIIGAIAGTILVLALVLGITA--W----GYKNYRRE 767

  Fly   795 RGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALL---KSPSDSTPSAG 856
            |.....:.:|..|.:....:..       ||.   :.|..:|:....||:|   :..:.|.|...
Frog   768 RQIPQGDYVKKPGDADSFYSDL-------PPG---VSSNSASSSKKRSAILSHFQISACSIPHYS 822

  Fly   857 LFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPE 921
            :......|..|  ::..|.:.:...|:...|....:...|:                       .
Frog   823 ISQNISLFCRR--SNGLSHSWSERIPDTKHVSDVCENGRPR-----------------------S 862

  Fly   922 ATWVRPAPALPPPNPGSTARPIISPPKLDSSTLTMVPLK---DSTEDLSPSRSAP-PVP 976
            .:|.....:......|...||      ..:||.|:.|.|   .||..::.||..| |:|
Frog   863 NSWQGNVSSSRKKLRGKRFRP------RSNSTETLSPAKSPSSSTGSIASSRKYPYPMP 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	41/124 (33%)
		Reprolysin	269..464	CDD:279729	57/202 (28%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	56/200 (28%)
		Disintegrin	479..555	CDD:278623	34/78 (44%)
		ACR	558..701	CDD:214743	49/144 (34%)
adam22	XP_031759145.1	Pep_M12B_propep	71..190	CDD:396235	45/161 (28%)
		Reprolysin	241..440	CDD:396140	57/203 (28%)
		DISIN	455..530	CDD:214490	34/79 (43%)
		ACR	532..673	CDD:214743	49/144 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8616
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.110