DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and adam23

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	NP_001233135.1	Gene:	adam23 / 100494499	XenbaseID:	XB-GENE-988267	Length:	815	Species:	Xenopus tropicalis

Alignment Length:	784	Identity:	229/784 - (29%)
Similarity:	352/784 - (44%)	Gaps:	93/784 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NTCLQQHILQPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHT 79
            |..:|:.|..|:....:...|.| |..| ||:     |..|.|.:|.:             .:|.
Frog    86 NNAIQKEITMPSRLVYYINKESE-SPYH-VLD-----TKARDQPKHNK-------------AVHL 130

  Fly    80 PQISLSYTHEGKRVVVDLQRNDLLLPNSHF-LRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIR 143
            .|.|......|...::||..|:.||...:. :.|.:.....|.|.          :.|:|.|.||
Frog   131 AQASFQIEAFGSTFILDLTLNNGLLSLDYSEIEYSDGKPKLTKGG----------EHCYYHGSIR 185

  Fly   144 GKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCG--YDNH 206
            |...|.||:|||:| |.|:..||..||.|||       :...|.....:..|....|.|  ...|
Frog   186 GVNNSRVAISTCNG-LHGMFDDGTYTYTIHP-------VDITHSSKSTSRPHIIERTAGSQISVH 242

  Fly   207 RDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVE 271
            :|..:...||.:...       :.|..         .|||||:     :.:..|....:...|||
Frog   243 QDSLAESEEKVNSHK-------TPPTE---------WLRKRRK-----RALPAPRGIFEEMKYVE 286

  Fly   272 LVIVVDNKVYKNFQENTKKVHQYCKGIANIINALY-VPLNIFVALVGVVIWNESNEIEFSSDGDL 335
            |:||.|:::||..:.:....:.:.|.:.|:::::| ..||..|.||.|..|.:.:.|..|.|...
Frog   287 LMIVNDHQMYKKHRSSHMYTNNFAKSVVNLVDSVYKEQLNTRVVLVAVETWTDKDRIPISPDPIK 351

  Fly   336 TLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVAT 400
            .|.:|..||... :..|. |...||:...|.......:..|.:|:  .:.||.:........:|.
Frog   352 MLHDFSKYRQHH-IKQHA-DAVHLLSNGTFHYKRSSMSYFGGVCS--ITRGVGVNEYGLLLSMAQ 412

  Fly   401 TMAHEMGHNFGMEHD----TSDCHCRDE--KCVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYC 459
            .:|..:..|.|::.:    .|.|.|.:.  .|:|..:.. :....:|.|||.:.....:||...|
Frog   413 QLAQSLAQNLGIQWEPASRKSKCDCTENFGGCIMEETGV-YHSRRFSKCSIAEYKEFLNRGGGSC 476

  Fly   460 LRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRP 524
            |.|:|.:|||...||||:||.||:||||....|...||  :.|.| |..|.|:.|.||: |:|..
Frog   477 LFNRPTKLFEVTECGNGYVEAGEECDCGFRMDCFGDCC--KKCSL-SNGAHCSDGPCCN-TSCLF 537

  Fly   525 KLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPT 589
            ......||.|.||||:.|:|||:|..||.::.::|...||..|..|::|.|::..|||:.:||..
Frog   538 LPREYDCRYAVNECDITEHCTGDSGQCPPNLRKQDGNACDSNQGRCYNGECKTRDNQCKHIWGTK 602

  Fly   590 GDNSE-HCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSH 652
            ...|: .||.| |||||..||||.:  ...:::|.:..|.||.|.|.::::....| :....:..
Frog   603 AAGSDKFCYEKLNTEGTEKGNCGKD--GDRWIQCSKHDVFCGFLLCANVSKSPRIG-KLEGDIPP 664

  Fly   653 SYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCP--- 714
            :||:|..::|.|..|.|.|. ..||.|...:||.||...||:|::|||:..:....    ||
Frog   665 TYINHQGRVVDCSGAHVILD-DETDMGYVEDGAPCGPSMMCLDRKCLPIHLLNISN----CPFGS 724

  Fly   715 --EDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPV 777
              :.|:|:|:|::...|.|...:.|..||.......|.:.....|..|:...|.:..:...:|.:
Frog   725 NGKVCSGHGVCSNEATCICSSTWAGTDCSIYDPKKEPPTKKDDLPKVSMATNRLIGAVAGTILAL 789

  Fly   778 VALF 781
            ..:|
Frog   790 GVIF 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	32/110 (29%)
		Reprolysin	269..464	CDD:279729	53/201 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	52/199 (26%)
		Disintegrin	479..555	CDD:278623	34/75 (45%)
		ACR	558..701	CDD:214743	52/144 (36%)
adam23	NP_001233135.1	Pep_M12B_propep	129..231	CDD:279848	36/119 (30%)
		Reprolysin	283..481	CDD:279729	53/202 (26%)
		ZnMc_adamalysin_II_like	283..479	CDD:239797	52/200 (26%)
		Disintegrin	496..568	CDD:278623	34/75 (45%)
		ACR	571..712	CDD:214743	52/144 (36%)
		DUF3844	729..797	CDD:289707	15/65 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8616
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010