DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and LOC100493925

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_012814909.3	Gene:	LOC100493925 / 100493925	-ID:	-	Length:	700	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	210/808 - (25%)
Similarity:	332/808 - (41%)	Gaps:	207/808 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 TYTVIRPQVEHGR--TKRSLLT---TLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNS-H 108
            :|.::.|.:...|  .|...||   .:|.||                 .|:.|.||.:|:|.. .
Frog    28 SYEIVTPLLVEERIVNKTRELTYVIMIDRTD-----------------YVIHLIRNPMLVPTDFK 75

  Fly   109 FLRYQNA-SRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFI 172
            ...|..| |......|::|.        |:|||:|:|.|.||||::||.| |.||:......|.|
Frog    76 VFSYNKAYSLYFDEPHILTQ--------CYYQGYIQGYPNSVVAMNTCSG-LRGIMHTDEFIYAI 131

  Fly   173 HP--HIDGRGRLQDD--------HYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNGLGGGI 227
            .|  .:|....:...        |.||..:..||..                :.:..:.||||
Frog   132 EPSQQLDNFKHVAYSMEQFKTTIHCLLNTSIYHPPT----------------KSSPIEQGLGG-- 178

  Fly   228 PSLPLRLDGGEFSRTLLRKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNKVYKNFQENTKKVH 292
                                               .|| ::|||:.:||..:.::...||...:.
Frog   179 -----------------------------------RNK-TAYVEVFMVVTQQQFEFHHENQTLLL 207

  Fly   293 QYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFS--------SDGDLTLRNFL--NYRSTK 347
            :....:.|.:||:|..||..:.|||:.||:..|.|..:        ||.....|.:|  |.:...
Frog   208 ESMLDLINGVNAVYQALNSHIVLVGIEIWSNENLINTAGKNVHAILSDFLAWKREYLDENIKCAV 272

  Fly   348 LVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMGHNFGM 412
            .||...::.....:..:..|.          |:.:.|..:...:...|.:......||:||..||
Frog   273 AVLSWRDETVSTSSLSHLRGA----------CSPDNSAFIIKMNLEKPVLSLNLFTHELGHILGM 327

  Fly   413 EHDTSDCHCRDEK--CVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGN 475
            :||||.|.|:..|  ||||  ::..:.:.:|:|:...:.:.|:.....||..      |...|||
Frog   328 KHDTSGCTCKSGKAACVMA--NSGLLSLGFSNCNEKDMEMFFASSEASCLWK------ELSQCGN 384

  Fly   476 GFVEPGEQCDCGLPEHCE-NACCNAQTCMLHSKNATCATGECCDLTTCRPKLAGSACREAENECD 539
            ..:|.||:||||..:.|. ..||:...|.|. :||.|.:|.||  ..||....|:.||..:.|||
Frog   385 NILEQGEECDCGSVQECAIIKCCDPTICKLR-ENAECLSGLCC--KDCRLLPKGTLCRIPKTECD 446

  Fly   540 LPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSE-HCYNK-NTE 602
            |.|||.|.|.:||.|:::::..||:.|.:.|:..||..::..|.|::|.....:. .|:.. ||.
Frog   447 LAEYCDGASSHCPLDMYQQNGSPCNNGTSLCYENTCYDYNKHCETVFGEGATVAPLSCFQSVNTI 511

  Fly   603 GTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNERLE-FGMESAAVLS--------------- 651
            |.|.|||...|   ..:.|...:|.||.|.|.:::.::: ...::|.:|:
Frog   512 GDRFGNCNTER---EMVECNIMNVMCGRLQCQNVSSQMKPIDNKTAIILTPNGNSWCWGIDFHSN 573

  Fly   652 -HSYISHDRKIVACRTALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDA------VRQKGM 709
             ||:                      |.|..|:||.|...|:|:::|||....      |::|
Frog   574 QHSF----------------------DLGTVPDGAPCDTGKICLNKRCLSSSVLSYDCDVKRK-- 614

  Fly   710 GKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSV-----GFKRF--- 766
                   |.|||:||:|.:|||...:...:|:::|.|||.||||.|..:..|     |..|.
Frog   615 -------CGGNGVCNNRKNCHCYSQWAPPNCTESGYGGSVDSGPVTKDSSLVFMPEGGMLRLYDT 672

  Fly   767 ---------LYVLFFFVLPVVALFWFLY 785
                     ::::..:...::..|..:|
Frog   673 SAARCPRLPVFIIILYQTLLIECFQSIY 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	36/114 (32%)
		Reprolysin	269..464	CDD:279729	53/206 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	53/204 (26%)
		Disintegrin	479..555	CDD:278623	34/76 (45%)
		ACR	558..701	CDD:214743	39/161 (24%)
LOC100493925	XP_012814909.3	Pep_M12B_propep	30..145	CDD:396235	40/140 (29%)
		ZnMc_adamalysin_II_like	183..376	CDD:239797	52/204 (25%)
		DISIN	388..463	CDD:214490	35/77 (45%)
		ACR	465..602	CDD:214743	39/161 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020