DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Meltrin and adam17

DIOPT Version :9

Sequence 1:NP_001027575.1 Gene:Meltrin / 3772109 FlyBaseID:FBgn0265140 Length:1407 Species:Drosophila melanogaster
Sequence 2:XP_031757449.1 Gene:adam17 / 100492947 XenbaseID:XB-GENE-492534 Length:855 Species:Xenopus tropicalis


Alignment Length:1099 Identity:232/1099 - (21%)
Similarity:343/1099 - (31%) Gaps:413/1099 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LFLLPLLLLNTCLQQHIL--QPAEATAFHQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLL 68
            :|.| ||.|......||.  ...|..|.||: |..|    :|.|:...::...| :|...||.|.
 Frog    27 IFAL-LLCLVVAEADHIPFGSQKEMPAKHQA-GLDS----LLSEYDVLSLSSIQ-QHSLRKRDLQ 84

  Fly    69 TTLDATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRYQNASRGATPGHVVTTFTKTEV 133
            :....       :..||:|        .|||        ||..|..:|......::.........
 Frog    85 SQSQL-------ERMLSFT--------ALQR--------HFKLYLTSSTELVSENLEALVLDGNG 126

  Fly   134 DLCHYQ--------GHIRGKPESVVALSTCDGALDG-IVIDGRQTYFIHP------HIDGRGRLQ 183
            ....||        ||:.|:..|.|.....||.... |..||.: |.|.|      :..|     
 Frog   127 KEKKYQVKWSDFFTGHVVGEHNSKVLAHIGDGDFTARITTDGEE-YNIEPLWRFVENTSG----- 185

  Fly   184 DDHYLLKQADMH-----PTNATCGYDNHRDD----HSHDYEKADGDNGLGGGIPSLPLRLDGGEF 239
            |:..:.:..|:.     .::..|||...::|    .....|.|:||:                  
 Frog   186 DNMLVYRSGDIKDFSRLKSSKVCGYIKPKEDLFKNEQDTAESAEGDD------------------ 232

  Fly   240 SRTLLRKRRQ--ADDS-----SQLIRGPYNANKY----------SSYVELVIVVDNKVYKN--FQ 285
              .|.|::||  ..||     ..|:...:...||          :..:||:..||: :|:|  :.
 Frog   233 --YLHREKRQRAGPDSLRNTCKMLVVADHRFFKYMGRGEESTTINYLIELIDRVDD-IYRNTSWD 294

  Fly   286 ENTKK----------VHQYCKGIA------NIINALYVPLNIFVALVGVVIWNESNEIE-FSSDG 333
            .|..|          ||:..:.:.      |:..|...|        ....|:....:| ||.| 
 Frog   295 NNQWKGYGVQIEQIIVHKEPENVTQGQKHYNMARAFPNP--------DKDAWDVKQLLEQFSYD- 350

  Fly   334 DLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKA--------LKGPICTYEYSGGVS-- 388
                   ::.::.::.|.|      |.|.::|..|.:|.|        ..|.||...|...:|  
 Frog   351 -------ISEKAAQVCLAH------LFTYQDFDMGTLGLAYVGSHKPNTHGGICPKAYENDLSKK 402

  Fly   389 -------MQHSPN--------PAMVATTMAHEMGHNFGMEHDTSD---CHCRDE---KCVMAASS 432
                   :..:.|        .|.:.||  ||:|||||.|||...   |...::   |.||...:
 Frog   403 AVYLNTGLTSTKNYGKTILTKEADLVTT--HELGHNFGSEHDPDSMEACAPSEDHGGKFVMYPIA 465

  Fly   433 TSFIPVN---WSSCSIDQLTIAFSRGMNYCLRNKPERLFESPTCGNGFVEPGEQCDCGLPEHCEN 494
            .|....|   :||||.:.:..........|.:.:..::     |||..|:.||:||.||.....:
 Frog   466 VSGDHENNKMFSSCSRESILRTLMAKSPICFKERNNKV-----CGNSRVDEGEECDPGLLHQHND 525

  Fly   495 ACCNAQTCMLH------SKNATCATGECCDLTTCRPKLAGSACREAEN-ECDLPEYCTGESEYCP 552
            .||.:. |...      .:|:.|..|       |:.:.|...|:||.| .|....||||.|..||
 Frog   526 PCCTSD-CKFQPGVHCSDRNSPCCRG-------CQFESAQKKCQEAINATCKGESYCTGSSSECP 582

  Fly   553 A-DVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGDNSEHCYNKNTEGTRLGNCGYNRLNK 616
            . .....||...|.|:  |.:|.||......|        |.:.|...:||.:            
 Frog   583 TPGNAENDTVCVDLGK--CVNGECRPFCEIER--------NLKSCACNDTENS------------ 625

  Fly   617 TFLRCEEQHVNCGMLHCIHLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPGLT 681
                |:   |.|          |.|.|:.|.....|.:..:.||                     
 Frog   626 ----CK---VCC----------RDENGVCSPQKDQHDHFLYLRK--------------------- 652

  Fly   682 PNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVG------------ 734
                                        ||||..     |.|::.|.|...|.            
 Frog   653 ----------------------------GKPCTV-----GFCDANGKCEKQVQDVIERIWDFIDK 684

  Fly   735 -----FGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALFW----FLYHCYKN 790
                 ||              ...|.:..|||       |:|..      |||    .|.||.  
 Frog   685 LSINMFG--------------KFLADNIVGSV-------VVFSL------LFWIPLSILVHCV-- 720

  Fly   791 GMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKS--TPSSTD---DMDSALLK--SP 848
                              .|.:..|..:.          .||  |||:.:   .||||.::  .|
 Frog   721 ------------------DKKLDKRYEET----------TKSLFTPSNVEMLSSMDSAPVRIVKP 757

  Fly   849 SDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTAPI 913
            |.|:.:...|.......:.|.:..::..:::..      ..|:|:|        |.|      ..
 Frog   758 SPSSQATNRFQALQTVPIVPTSAGAATKADHQR------MDTIQED--------PSV------DS 802

  Fly   914 HPPSPKPEATWVRPAPALPPPNPGSTAR--------PIISPPKLDSSTLTMVPLKDSTE 964
            |......|..:         ||.||.|:        |::...|..|..|......||.|
 Frog   803 HLDDQFEEDHF---------PNSGSPAKSFEDLTDHPVVRSDKASSFRLQRQGRVDSKE 852

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MeltrinNP_001027575.1 Pep_M12B_propep 64..174 CDD:279848 27/118 (23%)
Reprolysin 269..464 CDD:279729 56/247 (23%)
ZnMc_adamalysin_II_like 269..462 CDD:239797 56/245 (23%)
Disintegrin 479..555 CDD:278623 26/83 (31%)
ACR 558..701 CDD:214743 23/142 (16%)
adam17XP_031757449.1 Pep_M12B_propep 75..191 CDD:396235 31/144 (22%)
ZnMc_TACE_like 249..503 CDD:239798 59/278 (21%)
Disintegrin 510..584 CDD:395147 26/81 (32%)
ADAM17_MPD 607..668 CDD:406977 22/151 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D162519at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4147
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.040

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