DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Meltrin and adam15

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_031747227.1	Gene:	adam15 / 100145641	XenbaseID:	XB-GENE-5944438	Length:	878	Species:	Xenopus tropicalis

Alignment Length:	1017	Identity:	332/1017 - (32%)
Similarity:	464/1017 - (45%)	Gaps:	195/1017 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLPLLLLNTCLQQHILQPAEATAFHQSEGEKSKAH--PVLEEFSTYTVIRPQVEHGRTKRSLLTT 70
            ||.|||...||             ..|..:::.:|  .|..:...|..:.|::.....:..|...
Frog     8 LLQLLLCGLCL-------------GLSTRDRAVSHRVAVQPDSPLYWEVTPRLHRSGHRLGLQEA 59

  Fly    71 LD-ATDGLHTPQISLSYTHEGKRVVVDLQRNDLLLPNSHFLRY--QNASR--GATPGHVVTTFTK 130
            :. ..|.|   |||:..  :|::|.:||:||..|:|.||.|.|  .|.||  ...||
Frog    60 MQILPDDL---QISMEI--DGEQVQLDLERNRHLVPGSHRLIYYLPNGSRVTDQDPG-------- 111

  Fly   131 TEVDLCHYQGHIRGKPESVVALSTCDGALDGIVIDGRQTYFIHPHIDGRGRLQDDH-YLLKQADM 194
              |..|:|||.:.|:.....:||.|.| :.||::...:..|....:.|    ...| ::::....
Frog   112 --VANCYYQGQLEGQTGPWSSLSLCSG-IRGIIMTSPERGFSIEPLPG----DPSHKHIVRLTQE 169

  Fly   195 HPTNATCGYDNHRDDHSHDYEKADGDNGLGGGIPSLPLRLDGGEFSRTLLRKRRQADDSSQLIRG 259
            :|.|::||  |....|.           |.|.|         |..||.
Frog   170 NPKNSSCG--NSETPHL-----------LTGTI---------GTQSRE----------------- 195

  Fly   260 PYNANKYS-----SYVELVIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVV 319
            |::..|..     .:|||.:|.||:.||....:.|.:|.....|||.::|.|.|||:.||||.|.
Frog   196 PHHRTKRDVVTERKFVELAMVADNREYKLLHGDMKGLHIRMLEIANKVDAFYRPLNVRVALVAVE 260

  Fly   320 IWNESNEIEFSSDGDLTLRNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYS 384
            :||:.::|..|::...||..||::|...|:....||||||||...|....||.|....:|:...|
Frog   261 VWNQKDQINISTNPAETLYRFLSWRERSLLPLVANDNAQLLTGLTFKNSSVGMATLNSMCSSGGS 325

  Fly   385 GGVSMQHSPNPAMVATTMAHEMGHNFGMEHDTSDCHC----RDEKCVMAASSTSFIP-VNWSSCS 444
            |||||.||.:...||:|:||::|||.|:.||| |..|    :.:|.:|..|: .|:| :.:|:||
Frog   326 GGVSMDHSVSILGVASTLAHQLGHNLGLSHDT-DRKCGQPSKGKKWIMEPSA-GFLPGLEFSNCS 388

  Fly   445 IDQLTIAFSRGMNYCLRN--KPERLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSK 507
            :..|..:..||...||.|  .|:|||..|.|||..||.||||||||.:.|.:.||:|..|.|.|
Frog   389 LADLEFSLRRGGGMCLFNVPPPKRLFGEPQCGNFLVEEGEQCDCGLTQDCRDPCCDASLCQLRS- 452

  Fly   508 NATCATG-ECCDLTTCRPKLAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCF 571
            .|.|::| :||:  .|:.|::|..|||....|||||||.|||.:||.:|:.::.|.||  |.||:
Frog   453 GAQCSSGDQCCE--GCKLKVSGWMCREPLGACDLPEYCNGESPHCPPNVYLQNGETCD--QGYCY 513

  Fly   572 HGTCRSHSNQCRTLWGP-TGDNSEHCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCI 634
            .|.||:...||..:||| :....:.|::| |..|.:.||||.:. :.|:|.|.|..|.||.:.|.
Frog   514 RGECRTLRAQCLDVWGPGSAPAPDPCFSKVNVRGDKYGNCGRSP-DGTYLPCAESDVWCGKIQCQ 577

  Fly   635 HLNERLEFGMESAAVLSHSYISHDRKIVACRTALVDLGLQTTDPG-LTPNGAKCGVDKMCVDQRC 698
            ..:.|...|..:..||....|:...  ::||....|||....|.. |...|..||..|:|:.|:|
Frog   578 GGSARSRLGAGAQTVLVSVTINGSE--LSCRGTHFDLGDDIWDSAVLVATGTPCGTGKVCIGQKC 640

  Fly   699 LPVDAVRQKGMGKPCPEDCNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATD-PNGSVG 762
            ..|..::.:.    |...|||.|:|||..:||||.|:....|..:|.|||.|||..:. |:|| .
Frog   641 EDVSRLKVQN----CRNKCNGRGVCNSNSNCHCDPGWAPPDCVGSGQGGSIDSGSLSGRPDGS-S 700

  Fly   763 FKRFLYVLFFFVLPVVALFWFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTG----- 822
            ....|.|||..|:|::.|   |..||    :.|..|...:.|.|..|| ...|..|:|..
Frog   701 VTAALLVLFLLVVPLLVL---LGICY----IKRDTLQRRLGKFSTSSK-CQYRVAQSGNDPSRPQ 757

  Fly   823 -PPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAF 886
             |||.|..                                .|..|:.::..|      .||:
Frog   758 RPPPPNWA--------------------------------QGTELQVMSTHS------KGPD--- 781

  Fly   887 VQPTVQQDGPQRMAPPPPVVKPGTAPIHPPSPKPEATWVRPAPALP------PPNPGSTARPIIS 945
                 :.|.|.:..||.|:.|...|......|.|    .||.||.|      ||.||   :|  .
Frog   782 -----RPDPPAKPLPPDPLPKRCQADDEDRPPPP----ARPLPADPAPRQVQPPVPG---KP--P 832

  Fly   946 PPK-------LDSSTLTMVPLKDSTEDLSPSRSAPPVPLHAD 980
            |||       |..:.|..||........:|||.|||.| |:|
Frog   833 PPKKPLPLDPLSQAPLLTVPAYPDHMIAAPSRPAPPPP-HSD 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	36/114 (32%)
		Reprolysin	269..464	CDD:279729	82/201 (41%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	81/197 (41%)
		Disintegrin	479..555	CDD:278623	39/76 (51%)
		ACR	558..701	CDD:214743	49/145 (34%)
adam15	XP_031747227.1	Pep_M12B_propep	43..164	CDD:396235	39/140 (28%)
		ZnMc_adamalysin_II_like	209..406	CDD:239797	81/198 (41%)
		DISIN	425..500	CDD:214490	39/77 (51%)
		ACR	502..643	CDD:214743	49/145 (34%)
		EGF_2	655..678	CDD:400365	12/22 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I3999
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	424	1.000	Inparanoid score	I1736
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48765
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050