DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam22

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_021322679.1	Gene:	adam22 / 100126805	ZFINID:	ZDB-GENE-070810-1	Length:	978	Species:	Danio rerio

Alignment Length:	881	Identity:	248/881 - (28%)
Similarity:	391/881 - (44%)	Gaps:	187/881 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HQSEGEKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDATDGLHTPQISLSYTHEGKRVVVD 96
            :|.:|::..||..:.     |.||.:.:   :|::           |..|.|......|:..::|
Zfish    61 YQMDGDRQTAHDAVN-----TRIRMRSD---SKQN-----------HVAQASFQVQAFGQTFILD 106

  Fly    97 LQRNDLLLPNSHFLRYQN------ASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTC 155
            ::.|..||.:::..|:.:      .|:|.              :.|:|.|.:|..|:|.||||||
Zfish   107 VELNHDLLSSNYIERHLSEEGKPVVSKGG--------------EHCYYHGKVRDVPKSYVALSTC 157

  Fly   156 DGALDGIVIDGRQTYFIHPHIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGD 220
            .| |.|:..||..||.|.|        ..::...::..:|..     |.:|..|.|.|:..
Zfish   158 HG-LHGMFFDGNHTYMIEP--------GGENTTSEEVHVHMV-----YQSHSLDTSEDFIS---- 204

  Fly   221 NGLGGGIPSLPLRLDGGEFSRTLL------RKRRQADDSSQLIRGPYNANKYSSYVELVIVVDNK 279
                      |:.|....|....|      ||:|      |:.|.|.:....:.||||:::.|:.
Zfish   205 ----------PVHLAESLFENPPLFSAAHRRKKR------QISRNPRSVEDETKYVELMVINDHL 253

  Fly   280 VYKNFQENTKKVHQYCKGIANIINALYV--PLNIFVALVGVVIWNESNEIEFSSDGDLTLRNFLN 342
            :||..:.:..:.:.|.|.:.|:.: ||.  .||..:.||.:..|...|....:.|..:|||.|:.
Zfish   254 MYKKHRLSVGQTNNYAKSVVNMAD-LYFKEQLNTRIVLVAMETWAADNRFNINDDPMVTLREFMK 317

  Fly   343 YRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTMAHEMG 407
            ||  :..:....|:..|.:...|.....|.:..|.:|:....|||:.....    :|.|:|..:|
Zfish   318 YR--RDFIKEKCDSVHLFSGNRFHSNWGGASYMGGVCSLTKGGGVNEYGKE----MAITLAQSLG 376

  Fly   408 HNFGMEHD-----TSDCHCRDE--KCVMAASSTSF-IPVNWSSCSIDQLTIAFSRGMNYCLRNKP 464
            .|.|:..|     ..:|.|.|:  .|:|  ....| :|..:|.|::::.....:.|...||.|||
Zfish   377 QNIGIFSDKKRILNGECKCEDKWSGCIM--DDVGFYLPERFSDCNVEEFHDFLNSGGGACLFNKP 439

  Fly   465 ERLFESPTCGNGFVEPGEQCDCGLPEHC----ENACCNAQTCMLHSKNATCATGECCDLTTCRPK 525
            .:|.:.|.|||||||.||:||||.|..|    ||.|   :.||| ::.|.|:.|.||  ..|:.:
Zfish   440 SKLLDPPECGNGFVEAGEECDCGSPAECAKEGENCC---KKCML-TQGAKCSDGLCC--KNCQLE 498

  Fly   526 LAGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTG 590
            ..|..||||.|:||:||.|||.|..||.::.:.|...|:..|..||:|.|::...||:.|||...
Zfish   499 FMGVLCREAVNDCDIPEMCTGNSSQCPPNLHKMDGYTCEKDQGRCFNGRCKTKDRQCKYLWGEKA 563

  Fly   591 DNSE-HCYNK-NTEGTRLGNCGYNRLNKTFLRCEEQHVNCGMLHCIHLNE-----RLEFGMESAA 648
            .::: .||.| |.|||..||||  |...|:::|::|.|:||.|.|.:::.     .|:.|:.|.:
Zfish   564 TSADKFCYEKLNIEGTEKGNCG--RDKDTWIQCKKQDVHCGYLLCSNISPAPRLGELQGGLTSFS 626

  Fly   649 VLSHSYISHDRKIVACR--TALVDLGLQTTDPGLTPNGAKCGVDKMCVDQRCLPVDAVRQKGMGK 711
            |..|| .|.|     |.  ..|:|   ..||.|...:|..||.|::|.:.:||||    |.....
Zfish   627 VAQHS-ASLD-----CSGGHVLID---GDTDLGYVEDGTACGTDRICFNHKCLPV----QDFNFS 678

  Fly   712 PCPED-----CNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLF 771
            .||..     |:|:|:|::...|.|::|:.||.|:            ||.|           :.:
Zfish   679 TCPGTNERVICSGHGVCSNELRCVCELGWAGEDCN------------ATSP-----------LSY 720

  Fly   772 FFVLPVVALFWFLYHCYKNGMLTR----GKLADNILK-------SSGGSKPITTR------TNQN 819
            ..|.|...         .:|::|.    |.:|.:||.       |:.|.|....|      .::.
Zfish   721 LLVRPTAK---------TSGIITTNIIIGAIAGSILVLALILGISAWGYKTYRQRQYVESDVHRR 776

  Fly   820 GTGPPPSNGLLKSTPSSTDDMDSALLKSPSDSTPSA 855
            ...|.|....:|. |...|.:.|.:.:..|.::.|:
Zfish   777 FCRPMPPGDYVKK-PGDADSLYSDMPQGVSSNSGSS 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	32/115 (28%)
		Reprolysin	269..464	CDD:279729	54/204 (26%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	53/202 (26%)
		Disintegrin	479..555	CDD:278623	37/79 (47%)
		ACR	558..701	CDD:214743	53/151 (35%)
adam22	XP_021322679.1	Pep_M12B_propep	74..191	CDD:307618	37/163 (23%)
		Reprolysin	242..439	CDD:330960	54/205 (26%)
		Disintegrin	454..527	CDD:306668	37/78 (47%)
		ACR	531..672	CDD:214743	53/151 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9267
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.950