DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Meltrin and adam8b

DIOPT Version :9

Sequence 1:	NP_001027575.1	Gene:	Meltrin / 3772109	FlyBaseID:	FBgn0265140	Length:	1407	Species:	Drosophila melanogaster
Sequence 2:	XP_003199621.2	Gene:	adam8b / 100005593	ZFINID:	ZDB-GENE-070808-1	Length:	819	Species:	Danio rerio

Alignment Length:	964	Identity:	289/964 - (29%)
Similarity:	419/964 - (43%)	Gaps:	224/964 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EKSKAHPVLEEFSTYTVIRPQVEHGRTKRSLLTTLDA-----TDGLHTPQISLSYTHEGKRVVVD 96
            |..:..|.:|.|.   |:||       ||..|:.:.:     :...:..:::.....||:..|:.
Zfish    22 ESIRTLPHVERFD---VVRP-------KRLNLSKVQSDKNPPSHEKYPDRLAYKLFFEGENHVIH 76

  Fly    97 LQRNDLLLPNSHF-LRYQNASRGATPGHVVTTFTKTEVDLCHYQGHIRGKPESVVALSTCDGALD 160
            |::|..|:.:::. :.||:      .|.:|:. ..:..|.|:|.|||:....|.|::..|.| :.
Zfish    77 LEKNKQLVGHNYTEIYYQD------DGSIVSR-NPSFKDNCYYHGHIQDMEYSSVSVGICSG-IR 133

  Fly   161 GIVIDGRQTYFIHP---HIDGRGRLQDDHYLLKQADMHPTNATCGYDNHRDDHSHDYEKADGDNG 222
            |.|...:|.|.|.|   |.||      ||.|.|                   |.|
Zfish   134 GFVRVKQQVYLIEPLANHSDG------DHALYK-------------------HQH---------- 163

  Fly   223 LGGGIPSLPLRLDGGEFSRTLLRKRR-------------QADDSSQLIRGPYNANKYSS--YVEL 272
                                 ||:||             :...|:.|....:|...:.:  :|||
Zfish   164 ---------------------LRRRRSSAGEPKTMFYDHEPQVSAALKSSRWNMKSFQTPRFVEL 207

  Fly   273 VIVVDNKVYKNFQENTKKVHQYCKGIANIINALYVPLNIFVALVGVVIWNESNEIEFSSDGDLTL 337
            .:||||..|:||..:...:......:.|.::.||..|||.|.|||:.:|.:.::|..|...|.||
Zfish   208 FLVVDNTEYRNFGSSMDSIRARMLEVVNHVDKLYRSLNIRVMLVGLEVWMKQDQIVVSVSSDDTL 272

  Fly   338 RNFLNYRSTKLVLDHPNDNAQLLTKENFAGGVVGKALKGPICTYEYSGGVSMQHSPNPAMVATTM 402
            ..|:.:|.:.|:....:||||.:|..:|.|..||.|.|..:|. |.|.||:..|:.||..:|:|:
Zfish   273 SRFIEWRKSNLLKRVKHDNAQFVTGIDFLGDTVGLANKFAMCA-ESSAGVNQDHNQNPLGLASTI 336

  Fly   403 AHEMGHNFGMEHDTSDCHCRDEK----CVMAASSTSFIPVNWSSCSIDQLTIAFSRGMNYCLRNK 463
            |||||||.||.||...|.|....    |:|.....:..|..:|.||::|||:........||.:.
Zfish   337 AHEMGHNMGMSHDEDHCTCGSSVISSFCIMTERVGTLFPEQFSDCSLEQLTVFLDNANPSCLLDT 401

  Fly   464 PE--RLFESPTCGNGFVEPGEQCDCGLPEHCENACCNAQTCMLHSKNATCATGECCDLTTCRPKL 526
            |.  :|:..|.|||.|::|||:||||..|.|:|.||:..||.| ::.:.||.|:||:  .|:.|.
Zfish   402 PSSYKLYSGPVCGNAFLDPGEECDCGSVEECKNPCCDPMTCKL-TEGSRCAQGDCCE--NCQIKD 463

  Fly   527 AGSACREAENECDLPEYCTGESEYCPADVFRRDTEPCDGGQAYCFHGTCRSHSNQCRTLWGPTGD 591
            |.|.||.:.||||:||||||.||.||.:.||.:..||..||.||::|.|.:|...|:.||| ||.
Zfish   464 AESLCRASINECDVPEYCTGLSEKCPENDFRMNGIPCSSGQGYCYNGQCPTHLQHCQRLWG-TGA 527

  Fly   592 N--SEHCYNKNTEGTRLGNCGYNRLNKTFLR-CEEQHVNCGMLHCIHLNERLEFGMESAAVLSHS 653
            .  .:.|:.:||.|....:||   ..|..:| |..:::.||.:.|   ||..||.:.....:
Zfish   528 KVAPDTCFYQNTLGKNDSHCG---KTKDGIRPCARENMFCGKIFC---NEGNEFPVTGQKAV--- 583

  Fly   654 YISHDRKIVACRTALVDLGLQTTDPGLT--PNGAKCGVDKMCVDQRCLPVDAVRQKGMGKPCPED 716
                   ||..|......|.||.:..|:  |.|.|||.:|:|.|.:|..::..   |..:.|...
Zfish   584 -------IVTLRGQCNVAGDQTEEDALSMVPTGTKCGHNKVCYDYKCQELNIY---GSIEGCSLQ 638

  Fly   717 CNGNGICNSRGHCHCDVGFGGESCSKAGSGGSPDSGPATDPNGSVGFKRFLYVLFFFVLPVVALF 781
            |||.||||.:..||||.|:....|:...|..|...        ::|    :.|.....:.||...
Zfish   639 CNGRGICNHKKQCHCDPGWAPPYCNVKYSELSSAK--------TIG----ISVAVAVAVLVVICG 691

  Fly   782 WFLYHCYKNGMLTRGKLADNILKSSGGSKPITTRTNQNGTGPPPSNGLLKSTPSSTDDMDSALLK 846
            ..||| .|...::|.|                |:|..:|     ...||....|:..|
Zfish   692 AVLYH-KKRKAISRHK----------------TQTPTSG-----QTSLLFENNSAQKD------- 727

  Fly   847 SPSDSTPSAGLFGKFDGFTLRPLNDASSPASNYNGPNVAFVQPTVQQDGPQRMAPPPPVVKPGTA 911
            .|..|.|.      |.|.|:      |.|.:           |...:.||.|.||.||.
Zfish   728 RPEISQPI------FMGTTV------SQPCT-----------PLTARVGPTRPAPLPPK------ 763

  Fly   912 PIHPPSPKPEATWVR-----PAPALPPPNP----GS---------TARPIISPP 947
              .||| :|:.|.|.     |||.:||..|    ||         |.:.::.||
Zfish   764 --KPPS-QPQQTTVTQGTKLPAPPVPPVKPSLATGSWRNDHVTEDTVKVVLKPP 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Meltrin	NP_001027575.1	Pep_M12B_propep	64..174	CDD:279848	28/115 (24%)
		Reprolysin	269..464	CDD:279729	74/198 (37%)
		ZnMc_adamalysin_II_like	269..462	CDD:239797	74/196 (38%)
		Disintegrin	479..555	CDD:278623	40/75 (53%)
		ACR	558..701	CDD:214743	47/147 (32%)
adam8b	XP_003199621.2	Pep_M12B_propep	51..164	CDD:279848	35/176 (20%)
		Reprolysin	203..402	CDD:279729	74/199 (37%)
		ZnMc_adamalysin_II_like	203..400	CDD:239797	74/197 (38%)
		DISIN	419..491	CDD:214490	40/74 (54%)
		ACR	495..626	CDD:214743	47/147 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4239
eggNOG	1	0.900	-	-		E1_KOG3607
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162519at2759
OrthoFinder	1	1.000	-	-		FOG0000154
OrthoInspector	1	1.000	-	-		otm24708
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11905
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4147
SonicParanoid	1	1.000	-	-		X50
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.950