DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sotv and extl3

DIOPT Version :9

Sequence 1:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001008402.1	Gene:	extl3 / 493783	ZFINID:	ZDB-GENE-041124-2	Length:	917	Species:	Danio rerio

Alignment Length:	796	Identity:	238/796 - (29%)
Similarity:	359/796 - (45%)	Gaps:	204/796 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 PEAEQRARNVNCTFWDCLNIYKCE-HDRLKVYI-----YPLQEFVDEQSDKTATTLSSEYFQILE 139
            |::.|     :|....|.:..:|. .....||:     ||..|.:|        .|..:.|  ..
Zfish   164 PKSPQ-----SCRLHSCFDYARCPLTSGFPVYVYDTGSYPWGEKLD--------PLVKQAF--AS 213

  Fly   140 AVLKSRYYTSNPNEACLFL---------PSLDLLNQNVFDKHLAGAALASLDFW-DRGANHIIFN 194
            :|..|.|.|.|||.|||::         ||..|.:.:..:|.     |.:|.:| ..|.||::.:
Zfish   214 SVKSSVYVTDNPNIACLYIALVGEIQESPSSPLASPSDLEKQ-----LKALPYWRSDGHNHLLVH 273

  Fly   195 MLPGGAPSYNTVLDVNTDNAIIFGGGFDSWSYRPGFDVAIPVWSPRLVRQHAHATAQRKFLLVVA 259
             |...:.:.|.:.:|:|..|.:....|....||.|||:.:   ||.:     ||.::..||.|..
Zfish   274 -LSINSLTQNFLYNVSTGRAAVAQSTFFERQYREGFDLVV---SPLV-----HALSEPNFLEVPP 329

  Fly   260 QLNIL----------------------------------------PRFVRTLRELSLAHSEQLLL 284
            |:.:.                                        .|.:.||:.:..:|.:|:|:
Zfish   330 QVPVKRKYLFTFQGEKVESLRSSLLEAPPQSFEEEMEGDPPADYDDRIIGTLKAVQDSHLDQVLV 394

  Fly   285 LGACENL---DLTMRCPL-SQHHKSLE------YPRLLSRGKFCLL---GRSLRMGQPDLVEIMS 336
            ...|:|.   .|.....| .:....||      :..::|.|...|:   |.|:|     |.|.:.
Zfish   395 EFTCKNQAKPSLPTEWALCGKREDRLEVLKVSTFALVISPGDGQLVASAGCSMR-----LFEALE 454

  Fly   337 QHCIPVIAVDNYVLPFEDVIDWSLASVRI---RENELHSVMQKLKAISSVKIVEMQKQVQWLFSK 398
            ...|||:..|:..||:..:|.||.|.:.:   |..|||.:   |::||...::.|::|.::|:..
Zfish   455 VGAIPVVLGDHSKLPYHHLIRWSEAVIMVPKPRITELHFL---LRSISDNDLLAMRRQGRFLWET 516

  Fly   399 YFKDLKTVTLTALEVLESRI----FPLRARSS--------------------------------- 426
            ||...:::..|.|..:.:.|    .|:|...:
Zfish   517 YFSTSESIFNTILASVRTSIQIPAAPIREEPAQEIPHKAGKLAGTDANLADNGDLDLGPVEVEPP 581

  Fly   427 ------------------RQWN----------------TIDTNAR-----STFNPL--------- 443
                              |.||                .:.:.|:     :.|.|:
Zfish   582 YASPRFLRNFTYTAADVYRTWNRAPGPFHLFPHTPLDPVLPSEAKFLGSGTGFRPIGGGSGGSGK 646

  Fly   444 -FLPSL---APKSQGFTAVILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSI 504
             |..:|   .|:.| ||.|:|||:|.|.|...:::|..:|.|..::|:||:.|.....| .:|.|
Zfish   647 EFQAALGGNVPREQ-FTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNSPKPPSDDL-LWPDI 709

  Fly   505 SKPLKIRQTKENKLSNRFYPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRI 569
            ..|:.:.:|.:|.|:|||.|:..|||||||:|||| ..|..||:.||:.||||..|.|||||.|.
Zfish   710 GLPIVVVRTGKNSLNNRFLPWDAIETEAILSIDDD-AHLRHDEIMFGFRVWREARDRIVGFPGRF 773

  Fly   570 HVWENVTMRWHYESEWTNQISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLV 634
            |.|:.....|.|.|.::.::|||||||||.|||::::|::.||..|:|.|||::|||||||||||
Zfish   774 HAWDLNHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPRAIRDMVDEYINCEDIAMNFLV 838

  Fly   635 ANITNNPPIKVTPRKKFKCPECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVL 699
            ::||..||||||.|..|:||.|  .:.||.|.:|..||..||:.|.|:||.|||...:||.|.||
Zfish   839 SHITRKPPIKVTSRWTFRCPGC--PQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVL 901

  Fly   700 FRDNFP-DKLKRYNDI 714
            |:...| ||.|.:..|
Zfish   902 FKTRLPHDKTKCFKFI 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	82/345 (24%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	117/233 (50%)
extl3	NP_001008402.1	RILP-like	<79..>143	CDD:304877
		Exostosin	183..498	CDD:281069	82/346 (24%)
		Glyco_transf_64	661..894	CDD:286358	118/236 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920