DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sotv and extl3

DIOPT Version :9

Sequence 1:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001008036.1	Gene:	extl3 / 493398	XenbaseID:	XB-GENE-855819	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	776	Identity:	241/776 - (31%)
Similarity:	355/776 - (45%)	Gaps:	184/776 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 NCTFWDCLNIYKCE-HDRLKVYI-----YPLQEFVDEQSDKTATTLSSEYFQILEAVLKSR-YYT 148
            ||...:|.:..:|. .....|::     ||...|:|....           |.|||.:::. |.|
Frog   176 NCGLHNCFDYSRCPLTSGFPVFVYNSDQYPFGNFIDPLIK-----------QALEASVRNNVYVT 229

  Fly   149 SNPNEACLFLPSLDLLNQNVFDKHL-AGAALASLDFW-DRGANHIIFNMLPGGAPSYNTVLDVNT 211
            .|.|.||:::..:..:.:.|..|.. ....|.||.:| ..|.||:|.| |...:.:.|.:.:|:|
Frog   230 ENANNACIYVVLMGEMQEPVMPKPTELEEQLHSLPYWRTDGHNHLIIN-LSRKSETQNYLYNVST 293

  Fly   212 DNAIIFGGGFDSWSYRPGFDVAIPVWSPRLVRQHAHATAQRKFLLVVAQLNILPRF--------V 268
            ..|:|....|....||||||:.:   ||.:     ||.::..||.:..|:.:..::        :
Frog   294 GRAMIAQSTFYDLQYRPGFDIVV---SPLV-----HAMSEPNFLEIPPQVPVKRKYLFSFQGEKI 350

  Fly   269 RTLR-ELSLAHSEQ---------------LLLLGACEN--LDLTM---RCPLSQHHKSL------ 306
            .:|| .|..|.|.:               :..|.|.::  ||..|   .|. :|...||
Frog   351 ESLRSSLQEARSFEEEMEGNAPADYDDRIITTLKAVQDSKLDFVMVEFTCK-NQAKPSLPTEWAL 414

  Fly   307 -----EYPRLLSRGKFCLL------------GRSLRMGQPDLVEIMSQHCIPVIAVDNYVLPFED 354
                 :...||.:..|.|:            |.::|     |.|.:....||||..:...||:.|
Frog   415 CGERDDRLELLKQSTFALIITPGDSQLVISAGSAMR-----LFEALEVGAIPVILGEQVQLPYHD 474

  Fly   355 VIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWLFSKYFKDLKTVTLTALEVLESRI- 418
            .|.|:.|.:.:.:..:..|...|::||...::.:::|.::|:..||....||..|.|..:.:||
Frog   475 TIRWNEAVLILPKPRITEVHFLLRSISDNDLLSLRRQGRFLWETYFSTSDTVFNTILATVRTRIQ 539

  Fly   419 -----------------------------------------------------FPLRARS-SRQW 429
                                                                 |.|.|.. .|.|
Frog   540 IPAAPIKEEPAVEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPKYLRNFTLTAADIYRNW 604

  Fly   430 NT----IDTNARSTFNPLFLPSLA-------------------------------PKSQGFTAVI 459
            ||    ......:.|:|| |||.|                               |:.| ||.|:
Frog   605 NTAPGPFHLFPHTPFDPL-LPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPREQ-FTVVM 667

  Fly   460 LTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKENKLSNRFYP 524
            |||:|.|.|...:::|..:|.|..::|:||: .|.|.....:|.|..|:.|.:|::|.|:|||.|
Frog   668 LTYEREEVLMNSLERLNGLPYLNKVVVVWNS-PKLPSEDLLWPDIGVPIVIVRTEKNSLNNRFLP 731

  Fly   525 YPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWHYESEWTNQI 589
            :.:|||||:|:|||| ..|..||:.||:.||||..|.|||||.|.|.|:.....|.|.|.::.::
Frog   732 WDQIETEAVLSIDDD-AHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHRSWLYNSNYSCEL 795

  Fly   590 SMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKVTPRKKFKCP 654
            |||||||||.|||::::|::.||..|:|.|||::|||||||||||::||..||||||.|..|:||
Frog   796 SMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWTFRCP 860

  Fly   655 ECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFP-DKLKRYNDI 714
            .|  .:.||.|.:|..||..||:.|.|:||.|||...:||.|.|||:...| ||.|.:..|
Frog   861 GC--PQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTKCFKFI 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	80/334 (24%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	117/233 (50%)
extl3	NP_001008036.1	TPR_MLP1_2	<71..150	CDD:369600
		Exostosin	190..500	CDD:367297	80/335 (24%)
		Glyco_transf_64	663..900	CDD:370389	120/240 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010