DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sotv and ext1

DIOPT Version :9

Sequence 1:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001006730.1	Gene:	ext1 / 448393	XenbaseID:	XB-GENE-867525	Length:	738	Species:	Xenopus tropicalis

Alignment Length:	711	Identity:	233/711 - (32%)
Similarity:	367/711 - (51%)	Gaps:	90/711 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SPRDGFFHGKRDSHTLILDLEHIQELAVNPEAEQRARNVNCTFWDCLNIYKCEHDRLKVYIYPLQ 116
            |||.     |||.::.|.                  :...|....|.::..|..:..||||||.|
Frog    73 SPRQ-----KRDGNSSIY------------------KGKRCRMESCFDLALCRRNGFKVYIYPQQ 114

  Fly   117 EFVDEQSDKTATTLSSEYFQILEAVLKSRYYTSNPNEACLFLPSLDLLNQNVFDK---HLAGAAL 178
                 :.||    ||..|..||.|:..||.|||:|::||||:.|||.|:::....   |...:.:
Frog   115 -----KGDK----LSESYQHILAAIESSRLYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLKSKV 170

  Fly   179 ASLDFWDRGANHIIFNMLPGGAPSYNTVLDVNTDNAIIFGGGFDSWSYRPGFDVAIPVWSPRLVR 243
            .:|..|:.|.||:|||:..|..|.|...:..:...|::......:.::||.|||:||::|    :
Frog   171 QNLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFS----K 231

  Fly   244 QHAHATAQRKFLLVVAQLNILP------------RFVR-----TLRELSLAHS-EQLLLLGACEN 290
            .|.....::.||    :.|.:|            |::.     |...|...|: |.::||..|::
Frog   232 DHPRTGGEKGFL----RFNNIPPMRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKH 292

  Fly   291 -----LDLTMRCPL-SQHHKSLEYPRLLSRGKFCLLGRSLRMGQPDLVEIMSQHCIPVIAVDNYV 349
                 .....||.. :..::..:|..:|....|||:.|..|:|....:|.:...|:||:..:.:.
Frog   293 GKDWQKHKDARCDKDNAEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWE 357

  Fly   350 LPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWLFSKYFKDLKTVTLTALEVL 414
            |||.:||||:.|:|...|..|..:...:::|...||:.:::|.|:|:..||..::.:.||.||::
Frog   358 LPFSEVIDWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEII 422

  Fly   415 ESRIFPLRARSSRQWNTIDTNARSTF-----------NPLFLPSLAPKSQG-FTAVILTYDRVES 467
            :.|||...:|:|..||   .:..:.|           .|.:..:|..|:.. |||||.....:.|
Frog   423 QDRIFKHISRNSLMWN---KHPGALFVLPQYSAYLGDFPYYYSNLGAKTPSKFTAVIHAVTPLVS 484

  Fly   468 LFLLIQKLAVVPS----LQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKENKLSNRFYPYPEI 528
            ....|.||.|..:    ...|:|:||..|..|.. ..:|:.:.|:.:.:.:...:|:||.||..|
Frog   485 QSQPILKLLVAVAKSQYCYQIIVLWNCDKPLPAK-HRWPATTVPVIVIEGESKVMSSRFLPYDNI 548

  Fly   529 ETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWHYESEWTNQISMVL 593
            .|:|:|::|:|.::.|| |:||.:.||:.||:.|||:|:|.|.|::...||.|.|:|||..||||
Frog   549 VTDAVLSLDEDTVLSTT-EVDFAFTVWQSFPERIVGYPARSHFWDSAKERWGYTSKWTNDYSMVL 612

  Fly   594 TGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKVTPRKKFKCPECTN 658
            ||||.:|||:.::||:.:|..:|:.||:..|||||.|||||:.:|..||||||.:|::|......
Frog   613 TGAATYHKYYHYLYTNYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQ 677

  Fly   659 TEMLS--ADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFPDKLKRYNDIGSL 717
            |...|  ||.:|..:|..|::.|:..:|.|||...:.|.|||||:|......|:|.||..|
Frog   678 TSRASRWADPDHFAQRQTCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	88/301 (29%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	99/239 (41%)
ext1	NP_001006730.1	Exostosin	102..388	CDD:308581	88/302 (29%)
ext1	NP_001006730.1	Glyco_transf_64	472..717	CDD:312681	101/246 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920