DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sotv and Extl1

DIOPT Version :9

Sequence 1:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001101455.1	Gene:	Extl1 / 313610	RGDID:	1309572	Length:	670	Species:	Rattus norvegicus

Alignment Length:	739	Identity:	215/739 - (29%)
Similarity:	338/739 - (45%)	Gaps:	142/739 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YGLLVIVALCAGFLLWDLSSSPRDGFFHGKRDSHTLILDLEHIQELA---VNPEAEQR-----AR 88
            :.||:|:   .|.....|:.|||.  ..|:.......||...:|..:   .|||.:.:     :|
  Rat    15 FWLLLIL---LGVFPLRLAVSPRP--LPGRSQGWPRWLDATFLQSFSQPETNPEEDVQQLPRVSR 74

  Fly    89 NVNCTFWDCLNIYKCEHDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQILEAVLKSRYYTSNPNE 153
            ..:||:..|.:..||....||::::         |....||.:..  :||:::..||||..:|.|
  Rat    75 GSSCTWGACFDTSKCRGKVLKIFVH---------SAAGPTTEAQR--RILDSLEGSRYYALSPAE 128

  Fly   154 AC--LFLPSLDLLNQNVFDKHLAGAALASLDFWDRGANHIIFNMLPG------------GAPSYN 204
            ||  |||||.|          ..||.......|:.|.||::.::.|.            .:||
  Rat   129 ACLLLFLPSQD----------RRGACGPLPPNWNGGRNHLVLSLYPAPCTRLGQAMVAEASPS-- 181

  Fly   205 TVLDVNTDNAIIFGGGFDSWSYRPGFDVAIPV---------WSPRLVRQHA---HATAQRKFLLV 257
              ||:                :|||||||:|.         .:|..:::|.   .||     |:.
  Rat   182 --LDI----------------FRPGFDVALPYLPEAHPLKGGAPGSLQRHGPQPGAT-----LVA 223

  Fly   258 VAQLNILPRFVRTLRELSLAHSEQLLLLGACENLDLTMRCPLSQHHK-----SLEYP-RLLSRGK 316
            ||:       .|....::..|:.               .||..::.:     ...|| .:|....
  Rat   224 VAE-------ERGRWRITTTHAS---------------ACPWDRNCEQDPGPQQTYPGEILPNVT 266

  Fly   317 FCLL-GRSLRMGQPDLVEIMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAI 380
            |||: |.  |......::.:...||||:....:.|||.:||||:.|::...|.....|:..|:.:
  Rat   267 FCLIPGH--RSATSCFLQALQAGCIPVLLSPRWELPFSEVIDWTKAAIVADERLPLQVLAALREM 329

  Fly   381 SSVKIVEMQKQVQWLFSKYFKDLKTVTLTALEVLESRIFPLRARSSRQWN----------TIDTN 435
            ...:::.:::|.|:|::.||..::.|..|.||:::.||:...|..|..||          |..|:
  Rat   330 LPSRVLALRQQTQFLWTAYFSSVEKVVHTTLEIIQDRIWGASAHPSLMWNSPPGALLALPTFSTS 394

  Fly   436 ARS-TFNPLFLPSLAPKSQGFTAVILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLS 499
            .:. .|..|.|.| :|.| .|:|||......||...|||::|.......||::||::|..|   .
  Rat   395 LQDFPFYHLQLGS-SPGS-SFSAVIWVGVSEESPPKLIQEVAGSRHCAQILILWNSEKPPP---D 454

  Fly   500 TFPSISKPLKIRQTKENKLSNRFYPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVG 564
            .:|..:.||.:.: ...|:|:||:.|..|.|..||::|.. ..|:|.|:||.:.||:.||:.:||
  Rat   455 RWPKTAVPLTVIE-GHRKVSDRFFLYSNISTNVILSLDAQ-STLSTSEVDFAFVVWQSFPERMVG 517

  Fly   565 FPSRIHVWENVTMRWHYESEWTNQISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIA 629
            |.:..|.|:.....|.|.:|..|:.|||||.|||:|:|:..::||::|..::...||...|.||.
  Rat   518 FVTWSHFWDEARQGWGYSAEMANEFSMVLTTAAFYHRYYHTLFTHSLPKALRSIADETPTCVDIL 582

  Fly   630 MNFLVANITNNPPIKVTPRKKFKCPECTNTEMLSADLNHMRERSA----CIDRFSKIYGRMPLRT 690
            ||||||.:|..|||||...::.:    ....|.|.....:.|..|    ||:|.:...|.|||.:
  Rat   583 MNFLVATVTKLPPIKVPYSRQHQ----EAAPMASEGPRPVPEPQALDQDCINRLAAGLGHMPLVS 643

  Fly   691 VEFRADPVLFRDNFPDKLKRYNDI 714
            ...|.|||||:|....:.|:|..:
  Rat   644 SRVRLDPVLFKDPVSVQRKKYRSL 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	74/307 (24%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	87/237 (37%)
Extl1	NP_001101455.1	Exostosin	90..329	CDD:281069	74/308 (24%)
Extl1	NP_001101455.1	Glyco_transf_64	413..645	CDD:286358	88/240 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920