DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sotv and EXTL3

DIOPT Version :9

Sequence 1:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_001431.1	Gene:	EXTL3 / 2137	HGNCID:	3518	Length:	919	Species:	Homo sapiens

Alignment Length:	778	Identity:	230/778 - (29%)
Similarity:	356/778 - (45%)	Gaps:	190/778 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 CTFWDCLNIYKCE-HDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQILEAVLKSR-YYTSNPNEA 154
            |...:|.:..:|. .....||:|...:||      ..:.|.....|..:|..::. |.|.|.:.|
Human   177 CRLHNCFDYSRCPLTSGFPVYVYDSDQFV------FGSYLDPLVKQAFQATARANVYVTENADIA 235

  Fly   155 CLFLPSLDLLNQNV------FDKHLAGAALASLDFW-DRGANHIIFNMLPGGAPSYNTVLDVNTD 212
            ||::..:..:.:.|      .:|.     |.||..| ..|.||:|.| |...:.:.|.:.:|:|.
Human   236 CLYVILVGEMQEPVVLRPAELEKQ-----LYSLPHWRTDGHNHVIIN-LSRKSDTQNLLYNVSTG 294

  Fly   213 NAIIFGGGFDSWSYRPGFDVAIPVWSPRLVRQHAHATAQRKFLLVVAQLNIL------------- 264
            .|::....|.:..||||||:.:   ||.:     ||.::..|:.:..|:.:.
Human   295 RAMVAQSTFYTVQYRPGFDLVV---SPLV-----HAMSEPNFMEIPPQVPVKRKYLFTFQGEKIE 351

  Fly   265 -------------------------PRFVRTLRELSLAHSEQLLLLGACENL---DLTMRCPL-S 300
                                     .|.:.||:.:..:..:|:|:...|:|.   .|.....| .
Human   352 SLRSSLQEARSFEEEMEGDPPADYDDRIIATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCG 416

  Fly   301 QHHKSLEYPRLLSRGKFCLLGRSLRMGQPDLV----------EIMSQHCIPVIAVDNYVLPFEDV 355
            :....||   ||....|.|:   :..|.|.||          |.:....:||:..:...||::|:
Human   417 EREDRLE---LLKLSTFALI---ITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQDM 475

  Fly   356 IDWSLASVRI---RENELHSVMQKLKAISSVKIVEMQKQVQWLFSKYFKDLKTVTLTALEVLESR 417
            :.|:.|::.:   |..|:|.:   |:::|...::.|::|.::|:..||....::..|.|.::.:|
Human   476 LQWNEAALVVPKPRVTEVHFL---LRSLSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTR 537

  Fly   418 I----FPLRARSS---------------------------------------------------R 427
            |    .|:|..::                                                   |
Human   538 IQIPAAPIREEAAAEIPHRSGKAAGTDPNMADNGDLDLGPVETEPPYASPRYLRNFTLTVTDFYR 602

  Fly   428 QWN----TIDTNARSTFNPLFLPSLA-------------------------------PKSQGFTA 457
            .||    .......:.|:|: |||.|                               |:.| ||.
Human   603 SWNCAPGPFHLFPHTPFDPV-LPSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPREQ-FTV 665

  Fly   458 VILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKENKLSNRF 522
            |:|||:|.|.|...:::|..:|.|..::|:||: .|.|.....:|.|..|:.:.:|::|.|:|||
Human   666 VMLTYEREEVLMNSLERLNGLPYLNKVVVVWNS-PKLPSEDLLWPDIGVPIMVVRTEKNSLNNRF 729

  Fly   523 YPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWHYESEWTN 587
            .|:.||||||||:|||| ..|..||:.||:.||||..|.|||||.|.|.|:.....|.|.|.::.
Human   730 LPWNEIETEAILSIDDD-AHLRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSC 793

  Fly   588 QISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKVTPRKKFK 652
            ::|||||||||.|||::::|::.||..|:|.|||::|||||||||||::||..||||||.|..|:
Human   794 ELSMVLTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPPIKVTSRWTFR 858

  Fly   653 CPECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFP-DKLKRYNDI 714
            ||.|  .:.||.|.:|..||..||:.|.|:||.|||...:||.|.|||:...| ||.|.:..|
Human   859 CPGC--PQALSHDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLPHDKTKCFKFI 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	74/337 (22%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	118/233 (51%)
EXTL3	NP_001431.1	TPR_MLP1_2	<71..150	CDD:311742
		Exostosin	190..500	CDD:308581	74/338 (22%)
		Glyco_transf_64	663..900	CDD:312681	121/240 (50%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	723..728		2/4 (50%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	744..746		1/1 (100%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q9ES89	829..833		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314330at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920