Protein Alignment sotv and EXT2

DIOPT Version :10

• Sequence 1: NP_725536.1
• Gene: sotv / 3772101
• FlyBaseID: FBgn0029175
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_011518252.1
• Gene: EXT2 / 2132
• HGNCID: 3513
• Length: 764
• Species: Homo sapiens
• Alignment Length: 714
• Identity: 342/714 - (47%)
• Similarity: 478/714 - (66%)
• Gaps: 29/714 - (4%)

  Fly    22 PR---EHILNCLTYGLLVIVALCAG--FLLWDLSSSPRDGFFHGKRDSHTLILDLEHIQELAVNP 81
            ||   :|.:..:|...:|::.|.|.  |..|..|....:.:...||.    |.|:..::..|.:|
Human    62 PRMKTKHRIYYITLFSIVLLGLIATGMFQFWPHSIESSNDWNVEKRS----IRDVPVVRLPADSP 122

  Fly    82 EAEQRARNVNCTFWDCLNIYKC---EHDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQILEAVLK 143
            ..|:  .:::|....|.::|:|   ..:::|||||.|:::||:.....:.|:|.||.::|.|:..
Human   123 IPER--GDLSCRMHTCFDVYRCGFNPKNKIKVYIYALKKYVDDFGVSVSNTISREYNELLMAISD 185

  Fly   144 SRYYTSNPNEACLFLPSLDLLNQNVFDKHLAGAALASLDFWDRGANHIIFNMLPGGAPSYNTVLD 208
            |.|||.:.|.||||:||:|:||||.........|:|.|..||||.||::|||||||.|.|||.||
Human   186 SDYYTDDINRACLFVPSIDVLNQNTLRIKETAQAMAQLSRWDRGTNHLLFNMLPGGPPDYNTALD 250

  Fly   209 VNTDNAIIFGGGFDSWSYRPGFDVAIPVWSP--RLVRQHAHATAQRKFLLVVAQLNILPRFVRTL 271
            |..|.|::.||||.:|:||.|:||:|||:||  ..|.........|::.|:.:|:.:.|.:...|
Human   251 VPRDRALLAGGGFSTWTYRQGYDVSIPVYSPLSAEVDLPEKGPGPRQYFLLSSQVGLHPEYREDL 315

  Fly   272 RELSLAHSEQLLLLGACEN-----LDLTMRCPLSQHHKSLEYPRLLSRGKFCLLGRSLRMGQPDL 331
            ..|.:.|.|.:|:|..|.|     |.:..||   ..|:..:||::|....||::.|..|:||..|
Human   316 EALQVKHGESVLVLDKCTNLSEGVLSVRKRC---HKHQVFDYPQVLQEATFCVVLRGARLGQAVL 377

  Fly   332 VEIMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEMQKQVQWLF 396
            .:::...|:||:..|:|:|||.:|:||..|||.:.|.::..|...|::|...:|.|||:|.:|.:
Human   378 SDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQSIPQRQIEEMQRQARWFW 442

  Fly   397 SKYFKDLKTVTLTALEVLESRIFPLRARSSRQWNTIDTNA---RSTFNPLFLPSLAPKSQGFTAV 458
            ..||:.:|.:.|..|:::..||:|..|.|..:||  |..|   .|..||||||.:.|:||||||:
Human   443 EAYFQSIKAIALATLQIINDRIYPYAAISYEEWN--DPPAVKWGSVSNPLFLPLIPPQSQGFTAI 505

  Fly   459 ILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKENKLSNRFY 523
            :||||||||||.:|.:::.||||..:||:||||.|:||..|.:|.|..|||:.:|.||||||||:
Human   506 VLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEDSLWPKIRVPLKVVRTAENKLSNRFF 570

  Fly   524 PYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWHYESEWTNQ 588
            ||.||||||:|.|||||||||:|||.|||||||||||.:||:|.|:|:|::...:|.|||||||:
Human   571 PYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNE 635

  Fly   589 ISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKVTPRKKFKC 653
            :|||||||||:|||::::||:.||||||:|||.|||||||||||||||:|....|||||||||||
Human   636 VSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDAHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKC 700

  Fly   654 PECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFPDKLKRYNDIGSL 717
            ||||..:.||.|..||.|||.||::|:.::|.|||:.||.||||||::|:||:|||.:.:||||
Human   701 PECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sotv	NP_725536.1	Exostosin	106..380	CDD:397245	114/280 (41%)
		Glyco_transf_64	455..696	CDD:430488	160/240 (67%)
EXT2	XP_011518252.1	Exostosin	146..426	CDD:397245	114/282 (40%)
		Glyco_transf_64	502..743	CDD:430488	160/240 (67%)