DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sotv and Ext2

DIOPT Version :9

Sequence 1:	NP_725536.1	Gene:	sotv / 3772101	FlyBaseID:	FBgn0029175	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	XP_006498793.1	Gene:	Ext2 / 14043	MGIID:	108050	Length:	773	Species:	Mus musculus

Alignment Length:	722	Identity:	346/722 - (47%)
Similarity:	478/722 - (66%)	Gaps:	45/722 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PR---EHILNCLTYGLLVIVALCAG--FLLWDLS-SSPRDGFFHGKRDSHTLILDLEHIQELAV- 79
            ||   :|.:..:|...:|::.|.|.  |..|..| .|..||.           ::...|:|:.|
Mouse    71 PRMKTKHRIYYVTLFSIVLLGLIATGMFQFWPHSIESSSDGG-----------VEKRSIREVPVV 124

  Fly    80 -----NPEAEQRARNVNCTFWDCLNIYKC---EHDRLKVYIYPLQEFVDEQSDKTATTLSSEYFQ 136
                 :|..|:  .:::|....|.::|:|   ..:::|||||||:::||:.....::.:|.||.:
Mouse   125 RLPTDSPIPER--GDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVDDAGVPVSSAISREYNE 187

  Fly   137 ILEAVLKSRYYTSNPNEACLFLPSLDLLNQNVFDKHLAGAALASLDFWDRGANHIIFNMLPGGAP 201
            :|.|:..|.|||.:.|.||||:||:|:||||.........|||.|..||||.||::||||||..|
Mouse   188 LLTAISDSDYYTDDINRACLFVPSIDVLNQNPLRIKETAQALAQLSRWDRGTNHLLFNMLPGAPP 252

  Fly   202 SYNTVLDVNTDNAIIFGGGFDSWSYRPGFDVAIPVWSPRLVRQHA---HATAQRKFLLVVAQLNI 263
            .|||.|||..|.|::.||||.:|:||.|:||:|||:|| |..:.|   .|...|::.|:.:|:.|
Mouse   253 DYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVFSP-LSAEMALPEKAPGPRRYFLLSSQMAI 316

  Fly   264 LPRFVRTLRELSLAHSEQLLLLGACEN-----LDLTMRCPLSQHHKSLEYPRLLSRGKFCLLGRS 323
            .|.:...|..|...|.|.:|:|..|.|     |.:..||   ..|:..:||::|....||.:.|.
Mouse   317 HPEYREELEALQAKHQESVLVLDKCTNLSEGVLSVRKRC---HQHQVFDYPQVLQEATFCTVLRG 378

  Fly   324 LRMGQPDLVEIMSQHCIPVIAVDNYVLPFEDVIDWSLASVRIRENELHSVMQKLKAISSVKIVEM 388
            .|:||..|.:::...|:||:..|:|:|||.:|:||..|||.:.|.::..|...|:.|...:|.||
Mouse   379 ARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQNIPQRQIEEM 443

  Fly   389 QKQVQWLFSKYFKDLKTVTLTALEVLESRIFPLRARSSRQWNTIDTNA---RSTFNPLFLPSLAP 450
            |:|.:|.:..||:.:|.:.|..|:::..||:|..|.|..:||  |..|   .|..||||||.:.|
Mouse   444 QRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWN--DPPAVKWASVSNPLFLPLIPP 506

  Fly   451 KSQGFTAVILTYDRVESLFLLIQKLAVVPSLQSILVIWNNQKKSPPHLSTFPSISKPLKIRQTKE 515
            :||||||::||||||||||.:|.:::.||||..:||:||||.|:||..|.:|.|..|||:.:|.|
Mouse   507 QSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEESLWPKIRVPLKVVRTAE 571

  Fly   516 NKLSNRFYPYPEIETEAILTIDDDIIMLTTDELDFGYEVWREFPDHIVGFPSRIHVWENVTMRWH 580
            |||||||:||.||||||:|.|||||||||:|||.|||||||||||.:||:|.|:|:|::...:|.
Mouse   572 NKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWK 636

  Fly   581 YESEWTNQISMVLTGAAFHHKYWSHMYTHAMPGDIKDWVDEHMNCEDIAMNFLVANITNNPPIKV 645
            |||||||::|||||||||:|||::::||:.||||||:|||.|||||||||||||||:|....|||
Mouse   637 YESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDTHMNCEDIAMNFLVANVTGKAVIKV 701

  Fly   646 TPRKKFKCPECTNTEMLSADLNHMRERSACIDRFSKIYGRMPLRTVEFRADPVLFRDNFPDKLKR 710
            ||||||||||||..:.||.|..||.|||.||::|:.::|.|||:.||.||||||::|:||:|||.
Mouse   702 TPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKS 766

  Fly   711 YNDIGSL 717
            :.:||||
Mouse   767 FPNIGSL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sotv	NP_725536.1	Exostosin	105..380	CDD:281069	117/282 (41%)
sotv	NP_725536.1	Glyco_transf_64	455..689	CDD:286358	156/233 (67%)
Ext2	XP_006498793.1	Exostosin	155..435	CDD:367297	117/283 (41%)
Ext2	XP_006498793.1	Glyco_transf_64	511..752	CDD:370389	160/240 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847093
Domainoid	1	1.000	367	1.000	Domainoid score	I916
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H345
Inparanoid	1	1.050	685	1.000	Inparanoid score	I704
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48639
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008338
OrthoInspector	1	1.000	-	-		oto93374
orthoMCL	1	0.900	-	-		OOG6_106435
Panther	1	1.100	-	-	LDO	PTHR11062
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4562
SonicParanoid	1	1.000	-	-		X187
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930