DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kay and Atf2

DIOPT Version :9

Sequence 1:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_112280.1	Gene:	Atf2 / 81647	RGDID:	621862	Length:	487	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	96/417 - (23%)
Similarity:	147/417 - (35%)	Gaps:	78/417 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 ATCNTTAAATTSTTA--TSAAAGSDNNHSDNFAMDASEIATFLANELFLQQLGNFETGQSVLTLT 248
            :|.|.......:.||  |||.....:....|..:.:|:      :.:.:||.....|..:|:
  Rat   125 STTNDEKEIPLAQTAQPTSAIVRPASLQVPNVLLTSSD------SSVIIQQAVPSPTSSTVI--- 180

  Fly   249 TPTLTPTTTRNIEDTLGHL-----LSDTQTDRVAGCAGF---------AVPKVLPNAIDVLGMGI 299
              |..|::.|.|....|..     |.:.||..||..|..         |||.|.|..:.....||
  Rat   181 --TQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGI 243

  Fly   300 PTGVSSLPLQQTFDLSLGQGSESEDSNASYNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVN 364
            |...|..|:|....:.|......:....:..||............|..:...|.|.
  Rat   244 PGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRAQSEESRPQSLQQ--------- 299

  Fly   365 GGGVNNFSNVLAAVSSSRGSASVGSSNANTSNTPARRGGGRRPNRSTNMTPEEEQKRAVRRERNK 429
                       .|.|::...||...:...|.||..||      .|:.|..|:|::::.:  |||:
  Rat   300 -----------PATSTTETPASPAHTTPQTQNTSGRR------RRAANEDPDEKRRKFL--ERNR 345

  Fly   430 QAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATHR---ATCQKIRSD 491
            .||:|||::|......|.::.|.|......::.|:.:|.|...||:.||..|:   .|..:.:|
  Rat   346 AAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKS- 409

  Fly   492 MLSVVTCNGLIAPAGLLSAGSSGSG-----ASSHHNHNSNDSSNGTITGMDATLNSTGRSNSPLD 551
                          |..:|....|.     .||.|......||..|..|:.:|..:...:.|.|.
  Rat   410 --------------GYHTADKDDSSEDLSVPSSPHTEAIQHSSVSTSNGVSSTSKTEAGATSVLT 460

  Fly   552 LKPAANIDSLLMHIKDEPLDGAIDSGS 578
            .....:.:..|..|...|...|..|||
  Rat   461 QMADQSTEPALSQIVMAPSSQAQPSGS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	19/60 (32%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	19/58 (33%)
Atf2	NP_112280.1	C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	107..130		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..355		33/141 (23%)
		Essential for its histone acetyltransferase activity. /evidence=ECO:0000250	278..281		0/2 (0%)
		bZIP_ATF2	336..396	CDD:269835	19/61 (31%)
		coiled coil	336..396	CDD:269835	19/61 (31%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	336..356		8/21 (38%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	362..390		6/27 (22%)
		Nuclear export signal. /evidence=ECO:0000250	387..396		4/8 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..487		19/94 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810