DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kay and atf7a

DIOPT Version :9

Sequence 1:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_001025376.1	Gene:	atf7a / 566279	ZFINID:	ZDB-GENE-050721-2	Length:	497	Species:	Danio rerio

Alignment Length:	339	Identity:	88/339 - (25%)
Similarity:	129/339 - (38%)	Gaps:	98/339 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 TLTTPTLTPTTTRNIEDTLGH--------LLSDTQTDRVAGCAGFAVPKVLPNAIDVLGMGIPTG 302
            |:.:||...|.|.....|||.        :|.:.||          || |||..     |.:|:.
Zfish   181 TMPSPTSVITHTPPSNRTLGSPTVPYPMMMLPNGQT----------VP-VLPGP-----MQMPSV 229

  Fly   303 VS-SLPLQQTFDL------SLGQGSESEDSNASYN---DTQMNEEQDTTDTSSAHTDSTSYQAGH 357
            :| :.||....::      .||..|....|.:.||   :.:|.       ..:|.:..||...|.
Zfish   230 ISLARPLCMVPNIPGIPGPPLGGSSSGSSSPSGYNPHAEAKMR-------LKAALSQQTSSAQGC 287

  Fly   358 IMAGSVNGGGVNNFSNVLAAVSSSRGSASV----GSSNANTSNTPARRGGGRRPNRSTNMTPEEE 418
            :        ||...|:.:......:....|    ..|.|....:||:..|||| .|:.:..|:|.
Zfish   288 L--------GVAMGSSAMVPQRVEQSQLLVQHPDAPSPAQPQVSPAQPTGGRR-RRTADDDPDER 343

  Fly   419 QKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATHR- 482
            ::|.:  |||:.||:|||::|....|.|.::.|:|.....|:..|:..|.|....|:.||..|:
Zfish   344 RQRFL--ERNRAAASRCRQKRKIWVNSLEKKAEELTSINVSLSNEVSHLRNEVAHLKQLLLAHKD 406

  Fly   483 ---ATCQK-----------------------IRSDML-----SVVTCNGL--------IAPAGLL 508
               ...||                       |:...|     |||..|||        :|.:.|.
Zfish   407 CPVTNLQKKAAYLGDEHMKETSEPTGSPAPVIQHSSLAPSPSSVVGPNGLSSRAAAEAVAMSVLA 471

  Fly   509 SAGS--SGSGASSH 520
            ..||  .|||..||
Zfish   472 GMGSQQGGSGGPSH 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	21/60 (35%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	21/58 (36%)
atf7a	NP_001025376.1	C2H2 Zn finger	9..31	CDD:275370
		GCN4_cent	47..84	CDD:213399
		bZIP_ATF2	343..403	CDD:269835	21/61 (34%)
		coiled coil	343..403	CDD:269835	21/61 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I5099
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.890