DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kay and fosl1a

DIOPT Version :9

Sequence 1:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	XP_009289400.1	Gene:	fosl1a / 564241	ZFINID:	ZDB-GENE-061207-7	Length:	347	Species:	Danio rerio

Alignment Length:	435	Identity:	102/435 - (23%)
Similarity:	153/435 - (35%)	Gaps:	158/435 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 TTTRNIEDTLGHLLSDTQTDRVAGCAGFAVPKVLPNAIDVLGMGIPTGVSSLPLQQTFDLSLGQG 319
            :::.::..|.|......|...|||...| ||.:  |||          .|:..||.....|:|..
Zfish    25 SSSASVATTTGTTQQQQQKYSVAGSGQF-VPSL--NAI----------TSNQSLQWMLQPSIGTP 76

  Fly   320 SESEDSNASYN-----DTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVS 379
            ..|....:||.     ...||..|    .|.:|                           |:...
Zfish    77 GPSRALRSSYPLPPGIPATMNPPQ----PSQSH---------------------------LSRPG 110

  Fly   380 SSRGSASVGSSNANTSNTPARRGGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTN 444
            ..|.:|::||:.             ||  ....::|||.::|.:||||||.|||:||.||.:.|:
Zfish   111 VIRAAAAIGSTT-------------RR--NDEYLSPEELERRRIRRERNKMAAAKCRNRRRELTD 160

  Fly   445 ELTEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATHRATCQKIRSDMLSVVTCNGLIAPAGLLS 509
            .|..|.:|||.....::|||..|...|.:||.:...||..|:...|:
Zfish   161 TLQNETDQLEDEKSRLQKEIADLQKEKEKLELVFEAHRPICKVQESE------------------ 207

  Fly   510 AGSSGSGASSHHNHNSNDSSNGTITGMDATLNSTGRSNSPLDLKPAANIDSLLMHIKDEPLDGAI 574
                          :.:||||                          :|.| |..||.||:|.
Zfish   208 --------------SDSDSSN--------------------------DIPS-LSGIKIEPVDP-- 229

  Fly   575 DSGSSLDQDGP-----------PPSKRITLPPMSTMPHVHLSTILTPTGASSGSLQTPITSTAP- 627
                  |..||           .|..:||:||..:      ::.:|.....|.||.||:..:.|
Zfish   230 ------DLPGPSRETKHYAKINKPKPKITIPPPPS------ASSITGIPLESESLHTPVLISTPS 282

  Fly   628 -----GGFGSAFPVTSNGSSINNINSIGNNMNS----PTLNAHNK 663
                 .....::|.||..:|...:|.:.::.:|    |...||.:
Zfish   283 LTPFTASLVFSYPSTSLDTSSQALNLVTSHPSSQNPQPCAVAHRR 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	27/60 (45%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	27/58 (47%)
fosl1a	XP_009289400.1	bZIP_Fos	144..197	CDD:269869	22/52 (42%)
fosl1a	XP_009289400.1	coiled coil	144..196	CDD:269869	22/51 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10618
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002314
OrthoInspector	1	1.000	-	-		otm24837
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.900