DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kay and FOS

DIOPT Version :9

Sequence 1:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_005243.1	Gene:	FOS / 2353	HGNCID:	3796	Length:	380	Species:	Homo sapiens

Alignment Length:	420	Identity:	117/420 - (27%)
Similarity:	160/420 - (38%)	Gaps:	132/420 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 NASYNDTQMNEEQDTTDTSSAHT--DSTSYQAGHIMAGSVNGGGVN-------------NFSNVL 375
            ||.|       |..::..|||..  ||.||......:.|..|..||             ||...:
Human     7 NADY-------EASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTV 64

  Fly   376 AAVSSSRG------SASVGSSNANTSNTP-------------ARRG------GGR-----RPNRS 410
            .|:|:|..      .|.|.|...:.:..|             :|.|      |||     |..:.
Human    65 TAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKV 129

  Fly   411 TNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLE 475
            ..::||||:||.:||||||.|||:||.||.:.|:.|..|.:|||....:::.||..|...|.:||
Human   130 EQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLE 194

  Fly   476 YLLATHRATCQKIRSDM-----LSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITG 535
            ::||.||..| ||..|:     :||.:   |....||...
Human   195 FILAAHRPAC-KIPDDLGFPEEMSVAS---LDLTGGLPEV------------------------- 230

  Fly   536 MDATLNSTGRSNSPL--------DLKPAANIDSLLMHIKDEPLDGAIDSGSS------------- 579
              ||..|......||        .::|..:|.|  |.:|.||.|..:...||
Human   231 --ATPESEEAFTLPLLNDPEPKPSVEPVKSISS--MELKTEPFDDFLFPASSRPSGSETARSVPD 291

  Fly   580 LDQDG--------PPPSKRITLPPMSTMPHVHLSTILTPTGASSGSLQTPITS----TAP--GGF 630
            :|..|        |..|..:.:.||:|    .|..:.||....:.|. |..||    |.|  ..|
Human   292 MDLSGSFYAADWEPLHSGSLGMGPMAT----ELEPLCTPVVTCTPSC-TAYTSSFVFTYPEADSF 351

  Fly   631 GSAFPVTSNGSSINNINSIGNNMNSPTLNA 660
            .|.......|||.|..:|  ::::||||.|
Human   352 PSCAAAHRKGSSSNEPSS--DSLSSPTLLA 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	29/60 (48%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	27/58 (47%)
FOS	NP_005243.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..138		5/18 (28%)
		Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding	139..159		14/19 (74%)
		bZIP_Fos	147..200	CDD:269869	23/52 (44%)
		coiled coil	147..199	CDD:269869	22/51 (43%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	165..193		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..380		10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002314
OrthoInspector	1	1.000	-	-		otm42280
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23351
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R103
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.900