Protein Alignment kay and FOS

DIOPT Version :10

• Sequence 1: NP_001027577.2
• Gene: kay / 3772082
• FlyBaseID: FBgn0001297
• Length: 755
• Species: Drosophila melanogaster
• Sequence 2: NP_005243.1
• Gene: FOS / 2353
• HGNCID: 3796
• Length: 380
• Species: Homo sapiens
• Alignment Length: 420
• Identity: 117/420 - (27%)
• Similarity: 160/420 - (38%)
• Gaps: 132/420 - (31%)

  Fly   326 NASYNDTQMNEEQDTTDTSSAHT--DSTSYQAGHIMAGSVNGGGVN-------------NFSNVL 375
            ||.|       |..::..|||..  ||.||......:.|..|..||             ||...:
Human     7 NADY-------EASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANFIPTV 64

  Fly   376 AAVSSSRG------SASVGSSNANTSNTP-------------ARRG------GGR-----RPNRS 410
            .|:|:|..      .|.|.|...:.:..|             :|.|      |||     |..:.
Human    65 TAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRAQSIGRRGKV 129

  Fly   411 TNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVLTNSKNQLE 475
            ..::||||:||.:||||||.|||:||.||.:.|:.|..|.:|||....:::.||..|...|.:||
Human   130 EQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLE 194

  Fly   476 YLLATHRATCQKIRSDM-----LSVVTCNGLIAPAGLLSAGSSGSGASSHHNHNSNDSSNGTITG 535
            ::||.||..| ||..|:     :||.:   |....||...
Human   195 FILAAHRPAC-KIPDDLGFPEEMSVAS---LDLTGGLPEV------------------------- 230

  Fly   536 MDATLNSTGRSNSPL--------DLKPAANIDSLLMHIKDEPLDGAIDSGSS------------- 579
              ||..|......||        .::|..:|.|  |.:|.||.|..:...||
Human   231 --ATPESEEAFTLPLLNDPEPKPSVEPVKSISS--MELKTEPFDDFLFPASSRPSGSETARSVPD 291

  Fly   580 LDQDG--------PPPSKRITLPPMSTMPHVHLSTILTPTGASSGSLQTPITS----TAP--GGF 630
            :|..|        |..|..:.:.||:|    .|..:.||....:.|. |..||    |.|  ..|
Human   292 MDLSGSFYAADWEPLHSGSLGMGPMAT----ELEPLCTPVVTCTPSC-TAYTSSFVFTYPEADSF 351

  Fly   631 GSAFPVTSNGSSINNINSIGNNMNSPTLNA 660
            .|.......|||.|..:|  ::::||||.|
Human   352 PSCAAAHRKGSSSNEPSS--DSLSSPTLLA 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	29/60 (48%)
		coiled coil	421..480	CDD:269869	27/58 (47%)
FOS	NP_005243.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..138		5/18 (28%)
		Basic motif, required for the activation of phospholipid synthesis, but not for CDS1-binding	139..159		14/19 (74%)
		bZIP_Fos	147..200	CDD:269869	23/52 (44%)
		coiled coil	147..199	CDD:269869	22/51 (43%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	165..193		9/27 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..380		10/28 (36%)