DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kay and ATF2

DIOPT Version :9

Sequence 1:NP_001027577.2 Gene:kay / 3772082 FlyBaseID:FBgn0001297 Length:755 Species:Drosophila melanogaster
Sequence 2:NP_001243019.1 Gene:ATF2 / 1386 HGNCID:784 Length:505 Species:Homo sapiens


Alignment Length:400 Identity:91/400 - (22%)
Similarity:142/400 - (35%) Gaps:76/400 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 TSAAAGSDNNHSDNFAMDASEIATFLANELFLQQLGNFETGQSVLTLTTPTLTPTTTRNIEDTLG 265
            |||.....:....|..:.:|:      :.:.:||.....|..:|:     |..|::.|.|....|
Human   160 TSAIVRPASLQVPNVLLTSSD------SSVIIQQAVPSPTSSTVI-----TQAPSSNRPIVPVPG 213

  Fly   266 HL-----LSDTQTDRVAGCAGF---------AVPKVLPNAIDVLGMGIPTGVSSLPLQQTFDLSL 316
            ..     |.:.||..||..|..         |||.|.|..:.....|||...|..|:|....:.|
Human   214 PFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRL 278

  Fly   317 GQGSESEDSNASYNDTQMNEEQDTTDTSSAHTDSTSYQAGHIMAGSVNGGGVNNFSNVLAAVSSS 381
            ......:....:..||..........|.|..:...|.|.                    .|.|::
Human   279 KAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQ--------------------PATSTT 323

  Fly   382 RGSASVGSSNANTSNTPARRGGGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNEL 446
            ...||...:...|.:|..||      .|:.|..|:|::::.:  |||:.||:|||::|......|
Human   324 ETPASPAHTTPQTQSTSGRR------RRAANEDPDEKRRKFL--ERNRAAASRCRQKRKVWVQSL 380

  Fly   447 TEEVEQLEKRGESMRKEIEVLTNSKNQLEYLLATHR---ATCQKIRSDMLSVVTCNGLIAPAGLL 508
            .::.|.|......::.|:.:|.|...||:.||..|:   .|..:.:|               |..
Human   381 EKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKS---------------GYH 430

  Fly   509 SAGSSGSG-----ASSHHNHNSNDSSNGTITGMDATLNSTGRSNSPLDLKPAANIDSLLMHIKDE 568
            :|....|.     .||.|......||..|..|:.:|..:...:.|.|......:.:..|..|...
Human   431 TADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMA 495

  Fly   569 PLDGAIDSGS 578
            |...:..|||
Human   496 PSSQSQPSGS 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kayNP_001027577.2 bZIP_Fos 420..481 CDD:269869 19/60 (32%)
coiled coil 421..480 CDD:269869 19/58 (33%)
ATF2NP_001243019.1 Nuclear export signal 1 (N-NES) 1..7
C2H2 Zn finger 27..49 CDD:275370
GCN4_cent 65..102 CDD:213399
Herpes_BLLF1 <90..342 CDD:282904 44/212 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..155
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..373 33/141 (23%)
Essential for its histone acetyltransferase activity 296..299 0/2 (0%)
bZIP_ATF2 354..414 CDD:269835 19/61 (31%)
Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 354..374 8/21 (38%)
coiled coil 355..406 CDD:269835 15/52 (29%)
Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978 380..408 6/27 (22%)
Nuclear export signal 2 (C-NES) 405..414 4/8 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 425..472 12/61 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1414
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R103
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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