DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kay and BATF2

DIOPT Version :9

Sequence 1:	NP_001027577.2	Gene:	kay / 3772082	FlyBaseID:	FBgn0001297	Length:	755	Species:	Drosophila melanogaster
Sequence 2:	NP_612465.3	Gene:	BATF2 / 116071	HGNCID:	25163	Length:	274	Species:	Homo sapiens

Alignment Length:	307	Identity:	75/307 - (24%)
Similarity:	117/307 - (38%)	Gaps:	65/307 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 GGRRPNRSTNMTPEEEQKRAVRRERNKQAAARCRKRRVDQTNELTEEVEQLEKRGESMRKEIEVL 467
            ||   |.....|..:||:|.:::::|:.||.|.|::..|:.:.|.::.|.|||...::||||:.|
Human     5 GG---NGLLTQTDPKEQQRQLKKQKNRAAAQRSRQKHTDKADALHQQHESLEKDNLALRKEIQSL 66

  Fly   468 TNSKNQLEYLLATHRATCQKIRSDMLSVVTCNGLIAPAGLL-----SAGSSGSGASSHHNHNSND 527
            ..........|..|...|.         :.|....|| |||     :.|..|.|....|....
Human    67 QAELAWWSRTLHVHERLCP---------MDCASCSAP-GLLGCWDQAEGLLGPGPQGQHGCRE-- 119

  Fly   528 SSNGTITGMDATLNSTGRS---NSPLDLKPAANIDSLLMHIKDEPLDGAIDSGSSLDQDGPPPSK 589
                     ...|..|..|   ..||...|..:....|:..   ||. ::..|.::..:.|
Human   120 ---------QLELFQTPGSCYPAQPLSPGPQPHDSPSLLQC---PLP-SLSLGPAVVAEPP---- 167

  Fly   590 RITLPPMSTMPHVHLSTILTPTGASSGSLQTPITS-TAP-----------GGFGSAFPVTSNGSS 642
             :.|.|...:...|..:.|..:.:...:||..:|: |||           |..||:   ..|.||
Human   168 -VQLSPSPLLFASHTGSSLQGSSSKLSALQPSLTAQTAPPQPLELEHPTRGKLGSS---PDNPSS 228

  Fly   643 INNINSIGNNMNSPTLNA---HNKVPKERPN-TLAFQRPL---GQMH 682
            ...:..:.:..:.|.|:|   ...|....|: .|||  ||   .|:|
Human   229 ALGLARLQSREHKPALSAATWQGLVVDPSPHPLLAF--PLLSSAQVH 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kay	NP_001027577.2	bZIP_Fos	420..481	CDD:269869	18/60 (30%)
kay	NP_001027577.2	coiled coil	421..480	CDD:269869	18/58 (31%)
BATF2	NP_612465.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		14/44 (32%)
		bZIP_BATF	17..74	CDD:269849	19/56 (34%)
		coiled coil	19..73	CDD:269849	17/53 (32%)
		Basic motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	20..41		6/20 (30%)
		Leucine-zipper. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00978	45..66		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..151		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	187..229		11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1414
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810