DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus201 and EXO1

DIOPT Version :9

Sequence 1:	NP_001027230.1	Gene:	mus201 / 3772069	FlyBaseID:	FBgn0002887	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_014676.1	Gene:	EXO1 / 854198	SGDID:	S000005559	Length:	702	Species:	Saccharomyces cerevisiae

Alignment Length:	792	Identity:	147/792 - (18%)
Similarity:	288/792 - (36%)	Gaps:	229/792 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLHQVVKGFQDNKGSALSNAHLLGL------- 58
            ||:.||...::|...||.:...||::||:|...|||:          :|.|.|:.|.:
Yeast     1 MGIQGLLPQLKPIQNPVSLRRYEGEVLAIDGYAWLHR----------AACSCAYELAMGKPTDKY 55

  Fly    59 ----FHRLCKLLYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQAL----------- 108
                ..|...|..::|.|..:|||....:|:.|.::|:.:|.:....|:|:.|.
Yeast    56 LQFFIKRFSLLKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWACGEKKNAMDYFQ 120

  Fly   109 ----LLQSLAK-----------------------------EKVVQQALGKNAELLLKSPVKRPPP 140
                :...:||                             :.:||..:.::::||:..  .|...
Yeast   121 KCVDITPEMAKCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGIISEDSDLLVFG--CRRLI 183

  Fly   141 AKKND--------EDDLFKLP-ELPAASVQDNQDESEQDTSASASDSSFDESTAR---------- 186
            .|.||        .|:..||| :.|..|:.:    .|..|....|...:.....:
Yeast   184 TKLNDYGECLEICRDNFIKLPKKFPLGSLTN----EEIITMVCLSGCDYTNGIPKVGLITAMKLV 244

  Fly   187 ----------------------HSYNSSLQAIDVKSQHFRNLPADVRHEILTDIKETRKQSSWGR 229
                                  .:|.:..:|. |.:..|:.:...:|.:|::
Yeast   245 RRFNTIERIILSIQREGKLMIPDTYINEYEAA-VLAFQFQRVFCPIRKKIVS------------- 295

  Fly   230 LHELPARSDDFCSFQMKRL-------LKRRAVQESLEQAEQEMGGHT-LTYAELCDFFNEEGILT 286
            |:|:|....|..| :.|||       :.|...::.:...:.::..|. |..|        :|.|.
Yeast   296 LNEIPLYLKDTES-KRKRLYACIGFVIHRETQKKQIVHFDDDIDHHLHLKIA--------QGDLN 351

  Fly   287 PTAIEQCTRQISSDEHTRFLLVR-DLKKKAMESTKQEVKMEMIEEV--PAEEEDEKPSTSTKKEA 348
            |....|   .:::.||...|..: :::.....:|..|.|::.||..  ...:.|..|..:....:
Yeast   352 PYDFHQ---PLANREHKLQLASKSNIEFGKTNTTNSEAKVKPIESFFQKMTKLDHNPKVANNIHS 413

  Fly   349 VKSVDLGTEFDEDLAKALSMSMEETKVYDEKDYEYDSDQELRLNRAQTKQLRHAAKGPARAYMIE 413
            ::..       ||   .|:|:::..|:           ....:.:...|..|..........::|
Yeast   414 LRQA-------ED---KLTMAIKRRKL-----------SNANVVQETLKDTRSKFFNKPSMTVVE 457

  Fly   414 YGGMNDEEVG-NIMEATQFNDTQSLEKLLE----ITTVPTDMADNSIEEAKLISQAIEESKQLSQ 473
                |.:|.| :|.:..:..::||||:.:.    .|.:|:.....::|:...:|   ||..::..
Yeast   458 ----NFKEKGDSIQDFKEDTNSQSLEEPVSESQLSTQIPSSFITTNLEDDDNLS---EEVSEVVS 515

  Fly   474 AIEESKKNLNEDKV---EIVDTDTDSD---LEEVMEVQEL-----------DKGKKNLEICVDIT 521
            .|||.:|| :|.|.   ||.:||.|.|   .|:..|..|.           ...::::..|..:.
Yeast   516 DIEEDRKN-SEGKTIGNEIYNTDDDGDGDTSEDYSETAESRVPTSSTTSFPGSSQRSISGCTKVL 579

  Fly   522 GQADSNDLFADIFEDGEANK---IEKTISVEEDDDFIEVKDSEELKLDTEDENKPIT-----NKS 578
            .:...:..|:.:    .||:   ..:.:: ::....:.|..:.:...|..|....||     .||
Yeast   580 QKFRYSSSFSGV----NANRQPLFPRHVN-QKSRGMVYVNQNRDDDCDDNDGKNQITQRPSLRKS 639

  Fly   579 IKESNEVKPFIDEIIEVKDSQEAVPAEPNLKPDLESILNDLKKQTAAVKDIQLNVNEEEKPKPKV 643
            :..:...:..||  ::..|.:::..:.|        ||::..|:    :||:  ..:..:.:|.|
Yeast   640 LIGARSQRIVID--MKSVDERKSFNSSP--------ILHEESKK----RDIE--TTKSSQARPAV 688

  Fly   644 EISSILDELKVK 655
            ...|:|.:...|
Yeast   689 RSISLLSQFVYK 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus201	NP_001027230.1	rad2	1..1122	CDD:273166	147/792 (19%)
		PIN_XPG	1..>121	CDD:189038	36/174 (21%)
		PIN_XPG	<814..1084	CDD:189038
		H3TH_XPG	940..1045	CDD:188624
EXO1	NP_014676.1	PIN_EXO1	1..202	CDD:350207	44/212 (21%)
		H3TH_EXO1	215..287	CDD:188628	7/72 (10%)
		PTZ00108	<267..520	CDD:240271	56/306 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910