Protein Alignment mus201 and ercc5

DIOPT Version :10

• Sequence 1: NP_001027230.1
• Gene: mus201 / 3772069
• FlyBaseID: FBgn0002887
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: XP_003197653.2
• Gene: ercc5 / 541502
• ZFINID: ZDB-GENE-050327-28
• Length: 1010
• Species: Danio rerio
• Alignment Length: 1186
• Identity: 351/1186 - (29%)
• Similarity: 570/1186 - (48%)
• Gaps: 296/1186 - (24%)

  Fly     1 MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLHQVVKGFQDNKGSALSNAHLLGLFHRLCKL 65
            |||.|||||:|..|||:..||||||||||||||||:|.|||.:|..|:|:.|||||.||||||||
Zfish     1 MGVHGLWKLLESTGKPINPETLEGKILAVDISIWLNQAVKGVRDRDGNAVQNAHLLTLFHRLCKL 65

  Fly    66 LYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQALLLQSLAKEKVVQQALGKNAELL 130
            |::|:||||::||..|.||:.|:|.|:|:|.:.:.|:.:....|||:..|.:.::.|||:|::
Zfish    66 LFFRIRPVFVYDGDAPLLKKQTLAVRRQRREETNRESRQTSEKLLQTFLKRQAIRAALGENSQ-- 128

  Fly   131 LKSPVKRPP---PAKKNDEDDLFKLPELPAASVQDNQDESEQDTSASASDSSFDESTARHSYN-- 190
                 :..|   ..::::.||::.||.||          .|.|...|:|:...|...|.|:|:
Zfish   129 -----ESAPSLSSVRRDEHDDIYVLPALP----------PEDDRQESSSEEEKDGDEALHNYSRF 178

  Fly   191 -----SSLQAIDVKSQHFRNLPADVRHEILTDIKETRKQSSWGRLHELPARSDDFCSFQMKRLLK 250
                 .:..|:|:.|:.|..:|.:::||||.::||..|:.. ..||:.|.||.:|..:|:..||:
Zfish   179 QEELCDNPDAVDINSEQFSLMPPEIKHEILKEMKEFSKRRR-TLLHKPPERSGEFSQYQLAGLLQ 242

  Fly   251 RRAVQESLEQAEQEM-----GGHTLTYAELCDFFNEEGILTPTAIEQCTRQISSDEHTRFLLVRD 310
            |..:.:.||..||||     ||||       |..|.|           .|::.|::.:.::|::.
Zfish   243 RNRLNQRLECVEQEMNQRSSGGHT-------DQQNTE-----------IRRLVSEDSSHYILIKG 289

  Fly   311 LKKK----------AMEST-------KQEVKMEMIEEVPAEEEDEKPSTSTKKEAVKSVDLGTEF 358
            .:||          |:.|:       :.:.|.|.:....:|||:.|||:|:.....:|.  |...
Zfish   290 GQKKVSAVATPAAPALWSSSPWEPKGRNKGKPEPLWRPVSEEEENKPSSSSSSPEDQSA--GAPA 352

  Fly   359 DEDLAKALSMSMEETKVYDEKDYEYDSDQELRLNRAQTKQLRHAAKGPARAYMIEYGGMNDEEVG 423
            ......|:..:|.|::         |.||:::.:|::|
Zfish   353 SPRTLLAIQSAMMESE---------DEDQQIQDSRSKT--------------------------- 381

  Fly   424 NIMEATQFNDTQSLEKLLEITTVPTDMADNSIEEAKLISQAIEESKQLSQAIEESKKNLNEDKVE 488
            ||:.::...:.|.::.....|.|.|  :.:|.:|    .|.|:.|:..:..|..|    :||:.|
Zfish   382 NIIPSSSKTEEQQIQNSRTRTHVIT--SSSSEDE----DQHIQNSRARTHIITSS----SEDETE 436

  Fly   489 IVDTD------TDSDLEEVMEVQELDKGKKNLEICVDITGQADSNDLFADIFEDGEANKIEKTIS 547
            |..|.      ||..||          .:..|.:....:|..:...   .:.:|.|:::.|...|
Zfish   437 IRRTSDPAPGTTDLKLE----------SRTPLSLASAASGSLEQTH---TLQQDAESSEDESRSS 488

  Fly   548 VEEDDDFIEVKDSEELKLDTEDENKPITNKSIKESNEVKPFIDEIIEVKDSQEAVPAEPNLKPDL 612
            |     .::...||..:...|:|.|           |.:..:::|::.:||::  |:|
Zfish   489 V-----ILDCVRSETQRKTREEEEK-----------EEESTVNQILQFRDSRD--PSE------- 528

  Fly   613 ESILNDLKKQTAAVKDIQLNVNEEEKPKPKVEISSILDELKVKMADVKNITLDNVKLSNSVPIIL 677
                                 .||.:.:|        :|.:.|..:.:.
Zfish   529 ---------------------KEEREDQP--------EENREKREEEEE---------------- 548

  Fly   678 SSDDESTLKSSKIVPKQELIELCDSDDNKNNRLSPNKTPSKNKSIKDFFETSYVVKRTPDKSQAS 742
            ||.|||            .:|:.|:::          .|..::|..:..:|.|..:...::.:..
Zfish   549 SSADES------------FVEVSDAEE----------PPETDESHINTHQTDYNTEEKEEEVEEE 591

  Fly   743 NETSPGTPKTPKPFFRKRTPKSGRKRASDANEDSDEEVSPTKRSSKASKSLFEPKEPEEEKTVDP 807
            .|:|                    .:::|..||.||.|:             |.....|.:.:|
Zfish   592 EESS--------------------AQSTDQIEDVDESVN-------------EAPAVSEWEHID- 622

  Fly   808 EEIIKDAAEALKSQKTSEELQELATNLAQERKELEIERNRQDRMGMSISQRMSIDCQELLRLFGI 872
                            :||||.|...|..|::.|..:..:|.|...:::.:|..:.||||||||:
Zfish   623 ----------------TEELQLLDRELQDEQQTLREQHQQQQRSSSTVTGQMCQESQELLRLFGV 671

  Fly   873 PYIVAPMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYKNFFAQNKHVMEFRAEQIEQTFNC 937
            |:||||||||||||.|:..|.|||||||||||||||||.||:|||.|||:|..::...::.....
Zfish   672 PFIVAPMEAEAQCAALDRLDQTHGTITDDSDIWLFGGRHVYRNFFNQNKYVEHYQIVDMQNQLGL 736

  Fly   938 NRGKLIQLACLVGSDYTTGIHGIGAVTALEILASFSGQDANGPGICNQSVLQTLIKFRDWW---Q 999
            :|.|||.||.|:|||||.||.|:|.||.:|||..|.|           :.|:.|::..:||   |
Zfish   737 DRSKLINLAYLLGSDYTEGIPGVGYVTGMEILNEFPG-----------AGLEPLVQLSEWWTEAQ 790

  Fly  1000 AHKCSNLPPGSSARLALRKKLKNIELHEGFPSGAVVEAYLAPTIDDNRDAFSWGTPDVESIREFT 1064
            .:|..::.|..:   .::|||:|:::|.|||:.||.:|||.|::|.:..:||||.|.::.|:||.
Zfish   791 ENKKLSVNPKDT---KVKKKLRNLQIHPGFPNPAVAQAYLQPSVDQSDASFSWGRPHLDLIKEFC 852

  Fly  1065 RKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYFTAKSALRVQQPHVSKRVQLAIDKMSGKIDE 1129
            :..|||::.||::.|.||:|::..::.|..|.::|..:...|  |...|:|::.|:..|..|..|
Zfish   853 QSRFGWSSRKTEETLQPVLKQLQSQQTQLRIDSFFRLEQQDR--QQIRSERLRRAVICMKRKERE 915

  Fly  1130 TPEKPKKVTRTRRAKA 1145
            ..|:.:.|:..::.::
Zfish   916 EEEEDESVSAQKQGRS 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus201	NP_001027230.1	rad2	1..1122	CDD:273166	346/1161 (30%)
ercc5	XP_003197653.2	rad2	1..909	CDD:273166	346/1162 (30%)