Protein Alignment mus201 and Exo1

DIOPT Version :10

• Sequence 1: NP_001027230.1
• Gene: mus201 / 3772069
• FlyBaseID: FBgn0002887
• Length: 1236
• Species: Drosophila melanogaster
• Sequence 2: NP_036142.2
• Gene: Exo1 / 26909
• MGIID: 1349427
• Length: 837
• Species: Mus musculus
• Alignment Length: 952
• Identity: 180/952 - (18%)
• Similarity: 315/952 - (33%)
• Gaps: 231/952 - (24%)

  Fly     1 MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLH--------QVVKGFQDNK--GSALSNAHL 55
            ||:.||.:.|:...:||.|:..:|:.:|||...|||        ::.||...::  |..:...::
Mouse     1 MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNM 65

  Fly    56 LGLFHRLCKLLYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQALLLQSLAKEKVVQ 120
                     ||.|.|:|:.|||||....|::....|:::|                        |
Mouse    66 ---------LLSYGVKPILIFDGCTLPSKKEVERSRRERR------------------------Q 97

  Fly   121 QALGKNAELLLKSPVKRPPPAKKNDEDDLFKLPELPAASVQDNQDESEQDTSASASDSSFDESTA 185
            ..|.|..:||.:        .|.::..|.|      |.|:        ..|.|.|
Mouse    98 SNLLKGKQLLRE--------GKVSEARDCF------ARSI--------NITHAMA---------- 130

  Fly   186 RHSYNSSLQAIDVKSQHFRNLPADVRHEILTDIKETRKQSSW----GRLHELPARSDDFCSFQMK 246
             |....:.:|:.|              :.|....|...|.::    |.:..:.....|..:|..|
Mouse   131 -HKVIKAARALGV--------------DCLVAPYEADAQLAYLNKAGIVQAVITEDSDLLAFGCK 180

  Fly   247 R-LLKRRAVQESLEQAEQEMGGHTLTYAELCDFFNEEGILTPTAIEQC-----TRQISSDEHTRF 305
            : :||.......||..:..:|    ...:|.|.|.||.......:..|     .|.|...:..:.
Mouse   181 KVILKMDQFGNGLEVDQARLG----MCKQLGDVFTEEKFRYMCILSGCDYLASLRGIGLAKACKV 241

  Fly   306 L-------LVRDLKK--------------------KAMESTKQEVKMEMIEE--VP--AEEEDEK 339
            |       :|:.:||                    :|..:...::..:.|:.  ||  |..:|..
Mouse   242 LRLANNPDIVKVIKKIGHYLRMNITVPEDYITGFIRANNTFLYQLVFDPIQRKLVPLNAYGDDVN 306

  Fly   340 PSTSTKKEAVKSVDLGTEFDEDLAKALSMSMEETKVYDEKDYEYDSDQELRLNRAQTKQLRHAAK 404
            |.|.|.        .|....:.:|..:::...:...:::.| :|..|.....:|:.:...:...|
Mouse   307 PETLTY--------AGQYVGDSVALQIALGNRDVNTFEQID-DYSPDTMPAHSRSHSWNEKAGQK 362

  Fly   405 GPARAYMIEYGGMNDEEVGNIMEATQFNDTQSLEKLLE-ITTVPTDMADNSIEEAKLISQAIEES 468
            .|....:.........||.::..|.|..:..|...|.: |:|...::...|....:..::|:.|.
Mouse   363 PPGTNSIWHKNYCPRLEVNSVSHAPQLKEKPSTLGLKQVISTKGLNLPRKSCVLKRPRNEALAED 427

  Fly   469 KQLSQAIEESKKNLNEDKVEIVDTDTDSDLEEVMEVQELDKG-------KKNLEICVDITGQADS 526
            ..|||....|||                       ::|...|       .|..:.|.| :|.|..
Mouse   428 DLLSQYSSVSKK-----------------------IKENGCGDGTSPNSSKMSKSCPD-SGTAHK 468

  Fly   527 NDL---------FADIF----EDGEANKIEKT-----ISVEEDDDFIEVKDSEELKLDTEDENKP 573
            .|.         ||...    |:..|..:..|     .|.::.|:||..|:|.:...:|....|.
Mouse   469 TDAHTPSKMRNKFATFLQRRNEESGAVVVPGTRSRFFCSSQDFDNFIPKKESGQPLNETVATGKA 533

  Fly   574 ITN----KSIKESNEVKPFIDEIIEVKDSQEAVPAEPNLKPDLESILNDLKKQTAAVKDIQLNVN 634
            .|:    ....::...||..........||  :|....:.|:.|:..::..|...|:....|..
Mouse   534 TTSLLGALDCPDTEGHKPVDANGTHNLSSQ--IPGNAAVSPEDEAQSSETSKLLGAMSPPSLGT- 595

  Fly   635 EEEKPKPKVEISSILDELKVKMADVKNITLDNVKLSNSVPIILSS---------DDESTLKSSKI 690
                .:.....|..|.|.....:...:.||...:..:..|..|..         |.:|.:.....
Mouse   596 ----LRSCFSWSGTLREFSRTPSPSASTTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLGETS 656

  Fly   691 VPKQELIELCDSDDNKNNRLSPNKTPSKNKSIKDF-FETSYVVKRTPDKSQASNETSPGTPKTPK 754
            .|..||.....|.::.::....|.:.....|.:|. .|.|....::.|.....|.      |...
Mouse   657 QPLHELGCSSRSQESMDSSCGLNTSSLSQPSSRDSGSEESDCNNKSLDNQGEQNS------KQHL 715

  Fly   755 PFFRK-----RTPKSGRKRASDANEDSDEEVSP-----TKRSSKASKSLFEPKEPEEEKTVDPEE 809
            |.|.|     |....|..|:|..:..|..::.|     ....||.|.|:...|..:.|.....:.
Mouse   716 PHFSKKDGLRRNKVPGLCRSSSMDSFSTTKIKPLVPARVSGLSKKSGSMQTRKHHDVENKPGLQT 780

  Fly   810 IIKDAAEALKSQKTSEELQELATNLAQERKELEIERNRQDRM 851
            .|.:..:....:|.||:|......|:..:..:::....:|.:
Mouse   781 KISELWKNFGFKKDSEKLPSCKKPLSPVKDNIQLTPETEDEI 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mus201	NP_001027230.1	rad2	1..1122	CDD:273166	180/952 (19%)
Exo1	NP_036142.2	PIN_EXO1	1..201	CDD:350207	58/279 (21%)
		N-domain	1..99		32/130 (25%)
		Interaction with MSH3. /evidence=ECO:0000250	129..386		47/294 (16%)
		I-domain	138..229		20/108 (19%)
		H3TH_EXO1	213..289	CDD:188628	9/75 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	345..367		3/21 (14%)
		Interaction with MLH1. /evidence=ECO:0000250	387..488		24/124 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	440..477		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..589		7/35 (20%)
		Interaction with MSH2. /evidence=ECO:0000250	591..837		44/243 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..740		26/137 (19%)
		Interaction with MLH1. /evidence=ECO:0000250	778..837		7/45 (16%)