DRSC/TRiP Functional Genomics Resources

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Protein Alignment mus201 and Ercc5

DIOPT Version :10

Sequence 1:NP_001027230.1 Gene:mus201 / 3772069 FlyBaseID:FBgn0002887 Length:1236 Species:Drosophila melanogaster
Sequence 2:NP_035859.2 Gene:Ercc5 / 22592 MGIID:103582 Length:1170 Species:Mus musculus


Alignment Length:1325 Identity:387/1325 - (29%)
Similarity:607/1325 - (45%) Gaps:301/1325 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGVTGLWKLIEPCGKPVPVETLEGKILAVDISIWLHQVVKGFQDNKGSALSNAHLLGLFHRLCKL 65
            |||.|||||:|..|..|..|.||||:|||||||||:|.:||.:|:.|:.:.|||||.||||||||
Mouse     1 MGVQGLWKLLECSGHRVSPEALEGKVLAVDISIWLNQALKGVRDSHGNVIENAHLLTLFHRLCKL 65

  Fly    66 LYYRVRPVFIFDGCVPQLKRDTIARRQQQRNKLSNEADRIQALLLQSLAKEKVVQQALGKNAELL 130
            |::|:||:|:|||..|.||:.|:|:|:|:::..|.::.:....||::..|.:.::.|        
Mouse    66 LFFRIRPIFVFDGDAPLLKKQTLAKRRQRKDSASIDSRKTTEKLLKTFLKRQALKTA-------- 122

  Fly   131 LKSPVKRPPPA--KKNDEDDLFKLPELPAASVQDNQDESEQDTSASASDSSFDESTA-RHSYNSS 192
            .:|.....||:  :...:||::.||.||......:::|.|:...|     ..|:..| :..:..:
Mouse   123 FRSSRHEAPPSLTQVQRQDDIYVLPPLPEEEKHSSEEEDEKQWQA-----RMDQKQALQEEFFHN 182

  Fly   193 LQAIDVKSQHFRNLPADVRHEILTDIKETRKQSSWGRLHE-LPARSDDFCSFQMKRLLKRRAVQE 256
            .||||::|:.|.:||.:|:||||||:||..|:..  .|.| :|..|:||..:|:|.|||:..:.:
Mouse   183 PQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRR--TLFEAMPEESNDFSQYQLKGLLKKNYLNQ 245

  Fly   257 SLEQAEQEM-----GGHTLTYAELCDFFNEEGILTPTAIEQCTRQISSDEHTRFLLVRDLK-KKA 315
            .:|..::||     |.....|.:...|..|        :|  :|::.|::.:.::|::.:: ||.
Mouse   246 HIENVQKEMNQQHSGQIQRQYQDEGGFLKE--------VE--SRRVVSEDTSHYILIKGIQGKKV 300

  Fly   316 ME-------------STKQEVKMEMIEEVPAEEEDE--KPSTSTKKEAVKSVDLGTEFDEDLAKA 365
            |:             |....:|....|:|..|.|.|  .||..|.. |:::..||:..::     
Mouse   301 MDVDSESLPSSSNVHSVSSNLKSSPHEKVKPEREPEAAPPSPRTLL-AIQAAMLGSSSED----- 359

  Fly   366 LSMSMEETKVYDEKDYEYDSDQELRLNRAQTKQLRHAAKGPARAYMIEYGGMNDEEVGNIMEATQ 430
                                :.|.|..| |:|:....|...|       |.::......|.:|. 
Mouse   360 --------------------EPESREGR-QSKERNSGATADA-------GSISPRTCAAIQKAL- 395

  Fly   431 FNDTQSLEKLLEITTVPTDMADNSIEEAKLISQAIEESKQLSQAIEESKKNLNEDKVEIVDTDTD 495
              |..:.||:        ..:.:.:.|..|:...:|:.:...:..|....         |..||.
Mouse   396 --DDDNDEKV--------SGSSDDLAEKMLLGSGLEQEEHADETAERGGG---------VPFDTA 441

  Fly   496 SDLEEVMEVQELDKGKKNLEICV----DITGQADSNDLFADIFEDGEANKIEKTISVEEDDDFIE 556
            .....|.||:|          ||    ...||.||...|.......:..|  :|:|:..     .
Mouse   442 PLTPSVTEVKE----------CVTSGSSANGQTDSAHSFTTASHRCDTPK--ETVSLAR-----A 489

  Fly   557 VKDSEELKLDTEDENKPITNKSI---KESNEVKPFIDEIIEVKDSQEAVPAEPNLKPDLESILND 618
            ||::.::..:.|.|.:|......   ..|:.|...:.|            .||.|.|        
Mouse   490 VKEASQISSECEVEGRPAALSPAFIGTPSSHVSGVLSE------------REPTLAP-------- 534

  Fly   619 LKKQTAAVKDIQLNVNEEEKPKPKVEISSILDELKVKMADVKNITLDNVKLSNSVPIILSSDDES 683
              ..|....|..::::.|:.     |:.:.|..|:.|....:                ||||||:
Mouse   535 --PTTRTHSDQGIDIHPEDP-----ELQNGLYPLETKCNSSR----------------LSSDDET 576

  Fly   684 --------TLKSSKIVPKQELIELCDSDDNKNNRLSPNKTPSKNKSIKDFFETSYVVKRTPDKSQ 740
                    ...|:..||.:.:..|            .|..||..:...||.||  :..|...::.
Mouse   577 EGGQNPAPKACSTVHVPAEAMSNL------------ENALPSNAEERGDFQET--IQLREVPEAA 627

  Fly   741 ASNETSPGTPKTPKPFFRKRTPKSG-----RKRASDANEDSDEEVSPTKRSSKASKSLFEPKEPE 800
            |....|...|..|.....:.:...|     :...|::...::...:.|..|.|.::   ||:|..
Mouse   628 ARELISAPKPMGPMEMESEESESDGSFIEVQSVVSNSELQTESSEASTHLSEKDAE---EPRETL 689

  Fly   801 EEKTV-DPEEIIKDAA--EALKSQKTS----------------EELQELATNLAQERKELEIERN 846
            ||.|. |.|.:::|::  ||::..:.:                |||..|.:||..|:..|:.::.
Mouse   690 EEGTSRDTECLLQDSSDIEAMEGHREADIDAEDMPNEWQDINLEELDALESNLLAEQNSLKAQKQ 754

  Fly   847 RQDRMGMSISQRMSIDCQELLRLFGIPYIVAPMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRT 911
            :|||:..|::.:|.::.||||||||:|||.||||||||||.|:.||.|.|||||||||||||.|.
Mouse   755 QQDRIAASVTGQMFLESQELLRLFGVPYIQAPMEAEAQCAMLDLTDQTSGTITDDSDIWLFGARH 819

  Fly   912 VYKNFFAQNKHVMEFRAEQIEQTFNCNRGKLIQLACLVGSDYTTGIHGIGAVTALEILASFSGQD 976
            ||||||.:||.|..::..........:|.|||.||.|:|||||.||..:|.|||:|||..|.|:.
Mouse   820 VYKNFFNKNKFVEYYQYVDFYSQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGRG 884

  Fly   977 ANGPGICNQSVLQTLIKFRDWWQAHKCSNLPPGSSARLA-------LRKKLKNIELHEGFPSGAV 1034
                       |..|:||.:||  |:..|     :.::|       ::|||:.::|..|||:.||
Mouse   885 -----------LDPLLKFSEWW--HEAQN-----NKKVAENPYDTKVKKKLRKLQLTPGFPNPAV 931

  Fly  1035 VEAYLAPTIDDNRDAFSWGTPDVESIREFTRKSFGWTTSKTDDILMPVMKKINEKKIQGSIRNYF 1099
            .:|||.|.:||:|.:|.||.|||:.||||.::.|||...|||:.|.||:|.:|..:.|..|.::|
Mouse   932 ADAYLRPVVDDSRGSFLWGKPDVDKIREFCQRYFGWNRMKTDESLYPVLKHLNAHQTQLRIDSFF 996

  Fly  1100 TAKSALRVQQPHVSKRVQLAIDKMSGKIDETPEKPKKVT---RTRRAKAAPPTDDDLAIADVATK 1161
                  |:.|.          :|...|:.::....:.||   |..|.:.||    :|.....|..
Mouse   997 ------RLAQQ----------EKQDAKLIKSHRLNRAVTCILRKEREEKAP----ELTKVTEALD 1041

  Fly  1162 AARPKRGKRKAAPESVVLDGELPSTSQ-SIPKPEK------------CPRIP--SSVE------V 1205
            .|:.|..||           |||...: |:||..:            |...|  ||.|      |
Mouse  1042 DAKGKTQKR-----------ELPYKKETSVPKRRRPSGNGGFLGDPYCSESPQESSCEDGEGSSV 1095

  Fly  1206 IPQREKD-LEQMRLNKAKAAEILKN 1229
            :..|::. .|..:::.:...:::::
Mouse  1096 MSARQRSAAESSKISCSDVPDLVRD 1120

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mus201NP_001027230.1 rad2 1..1122 CDD:273166 359/1191 (30%)
Ercc5NP_035859.2 rad2 1..1028 CDD:273166 365/1216 (30%)
N-domain. /evidence=ECO:0000250|UniProtKB:P28715 1..78 49/76 (64%)
DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000250|UniProtKB:P28715 31..67 23/35 (66%)
Spacer region. /evidence=ECO:0000250|UniProtKB:P28715 79..784 196/860 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 304..479 44/238 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 520..587 19/109 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..701 26/117 (22%)
I-domain. /evidence=ECO:0000250|UniProtKB:P28715 785..880 58/94 (62%)
DNA-binding, may bind to the undamaged single-strand DNA of the DNA repair bubble. /evidence=ECO:0000250|UniProtKB:P28715 819..835 9/15 (60%)
DNA-binding, H2TH (helix-2turn-helix) motif which binds double-stranded DNA. /evidence=ECO:0000250|UniProtKB:P28715 847..879 21/31 (68%)
DNA-binding, may bind double-stranded DNA. /evidence=ECO:0000250|UniProtKB:P28715 911..917 1/5 (20%)
Interaction with PCNA. /evidence=ECO:0000250|UniProtKB:P28715 980..1008 8/43 (19%)
Interaction with ERCC6/CSB. /evidence=ECO:0000250|UniProtKB:P28715 1010..1170 26/126 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1146 20/99 (20%)
Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P28715 1049..1065 8/26 (31%)
Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P28715 1153..1170
Blue background indicates that the domain is not in the aligned region.

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