DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mus201 and gen1

DIOPT Version :9

Sequence 1:	NP_001027230.1	Gene:	mus201 / 3772069	FlyBaseID:	FBgn0002887	Length:	1236	Species:	Drosophila melanogaster
Sequence 2:	NP_001361766.1	Gene:	gen1 / 100145302	XenbaseID:	XB-GENE-940145	Length:	927	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	117/529 - (22%)
Similarity:	196/529 - (37%)	Gaps:	176/529 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   850 RMGMSISQRMSIDCQELLRLFGIPYIVAPMEAEAQCAFLNATDLTHGTITDDSDIWLFGGRTVYK 914
            :.|.|..:.:..:|..:|...|||::.|..||||.||:|||.....|.||:|.|::|:|.:|||:
Frog   104 KAGRSYFKSVLKECLLMLECLGIPWVQAAGEAEAMCAYLNAHGYVDGCITNDGDVFLYGAQTVYR 168

  Fly   915 NFF--AQNKHVMEFRAEQIEQTFNCNRGKLIQLACLVGSDY-TTGIHGIGAVTALEILASFSGQD 976
            ||.  .::.||..:...:|:.....:|.:|:.||.|:|.|| ..|:.|:..|.||:::...:|
Frog   169 NFTMNVKDPHVDCYEVSKIKAQLGLDREELVGLAILLGCDYLPKGVPGVRKVQALKLIEMLNG-- 231

  Fly   977 ANGPGICNQSVLQTLIKFRDW--------WQAHK----CS-NLPPGS-------------SARLA 1015
                    :|:||   :|..|        .:|.|    || ...|||             |.|..
Frog   232 --------ESLLQ---RFYQWEKDCNERGTKAPKKKPHCSVCCHPGSAKDHERNGCKMCGSDRFC 285

  Fly  1016 ----------------LRKKLKN-IELH--------EGFPSGAVVEAYLAPTIDDNR--DAFSWG 1053
                            .|:|.:| :|.:        ||||...|::.:|   |:.|:  ....||
Frog   286 EPHDYDYRCPCDWHKEQREKQENSVEFNIKRKSLRCEGFPYRQVIDEFL---INKNKLVKVLKWG 347

  Fly  1054 TPDVESIREFTRKSFGWTTSKTDDILMPVMK--KINEKK--------------IQGSIRN----- 1097
            .|.::..:.||.:...|....:.:.|:.::.  .:||:|              ::..|||
Frog   348 RPSLQCFQNFTAERMDWPRHYSCEKLLVLLTYYDMNERKAGRENGTQLQAVRIVKTRIRNGSPCF 412

  Fly  1098 ---------YFTA--------------KSALRVQQPHVSKRVQLAIDKMSGKIDETPEKPKKVTR 1139
                     |..|              :|..|...|||       :.....:..|..|...|..:
Frog   413 EIEWVKPDSYVFADDHPAESPLVTIEEESLFRAAYPHV-------VTMFHKEKQEAEENKLKCKK 470

  Fly  1140 TR-RAKAAPPTDD------DLAIADVATKA----------------ARPKRGKR---------KA 1172
            :: ::|||...||      :|::..|:.|.                .:|.|...         ..
Frog   471 SKPKSKAADDLDDVASLLSELSLKPVSEKQPPLELQEDGGDSDSVHEKPARDSNFLSLSSDADSG 535

  Fly  1173 APESVVLDGELPS------TSQSIPKPEKC---------------PRIPSSVEVIPQREKDLEQM 1216
            ....::||.:..|      |:.:.|....|               |.|.:.:..:.....|.:..
Frog   536 VERGILLDTKTDSEFFTSPTADNEPSNPLCSSPAPSNTQHLTAASPNISAVISELQLSSIDWDST 600

  Fly  1217 RLNKAKAAE 1225
            ..:|:..||
Frog   601 SFSKSPQAE 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mus201	NP_001027230.1	rad2	1..1122	CDD:273166	92/371 (25%)
		PIN_XPG	1..>121	CDD:189038
		PIN_XPG	<814..1084	CDD:189038	79/289 (27%)
		H3TH_XPG	940..1045	CDD:188624	38/156 (24%)
gen1	NP_001361766.1	PIN_GEN1	2..206	CDD:350217	37/101 (37%)
		H3TH_StructSpec-5'-nucleases	195..336	CDD:389913	38/156 (24%)
		Chromo_2	396..456	CDD:376128	10/66 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1094524at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920