DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nw and vcana

DIOPT Version :9

Sequence 1:	NP_001027435.2	Gene:	nw / 3772015	FlyBaseID:	FBgn0283508	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_021331663.1	Gene:	vcana / 116993	ZFINID:	ZDB-GENE-011023-1	Length:	8936	Species:	Danio rerio

Alignment Length:	521	Identity:	97/521 - (18%)
Similarity:	171/521 - (32%)	Gaps:	156/521 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LASFETKEKAESMTTYLKNAGYGNYD-----FWTSGNRLGTGMFLWMSTGLP----FNATFDFFE 114
            :||..:..::||       .|.|..|     |.||...|       .||..|    ...||
Zfish  5494 IASILSSSESES-------TGDGTVDVTSSEFTTSRPSL-------YSTQKPDKDLSKTTF---- 5540

  Fly   115 NSADAIQAGLLDPVDHNSNTSPQRTARDS--------------------SSGAEKGCVILKQPTL 159
            |:..|:.      |..:::...|:|..||                    |:|...|..:..|.|
Zfish  5541 NTTQAVS------VTSSTHVEDQKTETDSIKPALSFMSTASITKHTFTLSTGESTGQTVSSQDT- 5598

  Fly   160 KWMPEDCSAVKDFICEQTRCYYYNYGSIPVSSAQGRPITSTTPRTPASLMNLHVAATTTPLPLLM 224
                  .|.|:               ::.:.|:  .|.||||  ..:.:.:..|  ||.|....:
Zfish  5599 ------ASTVE---------------TVTIQSS--TPFTSTT--ATSGMQDTKV--TTKPSESTI 5636

  Fly   225 S-TSGAMYTAAKAKSSPAVGHRLIDDS---SSQQQPSFMSFKLNHDRSLPDTDST---------- 275
            : .||..::.|:.|....:...:...|   |.:..|..:....:...|.|.::|.
Zfish  5637 TYVSGMQFSTAQTKHLDEISSEITITSTMTSDKTTPKDVLSSSSLSSSFPSSESEASGDYTSEMF 5701

  Fly   276 -----------DVDVEDQEADLDGEEHDDHEAEGEEEHDE---HDNFEEHARELSNDNDGDIKE- 325
                       ...:.|||......:.|.........|.|   :...|..:||..:..|..:..
Zfish  5702 IKGFTTSSPLFTTTISDQELTRTPSDTDTTIPVSSSAHTETVSNQTIEAQSREPVSILDSTVTRT 5766

  Fly   326 -HVFPLSDNEL--------HPEVHSIEEVQQQ-----------LQQEDADADSAPAPAAAEDNES 370
             |.|..|:.|.        .....::.:|..|           |.|.: :..:.|:.:...:...
Zfish  5767 MHTFTSSNTEYSTAQTVASQDTASTVRKVTNQGSTPFTTTAANLMQNE-EVSTKPSESTINNVSE 5830

  Fly   371 SQHDAEADGEHEQDGAEGET----DLENETPVDLIKANEPLAMPSSTESPAAAIEERIKQIAQDF 431
            .|......|...:..:|...    ..:..||.|::..:...:. |||||.|:..|...|.||:|.
Zfish  5831 MQFSTAQTGHLSEISSESTVISTMTSDKTTPKDVLSLSLSSSF-SSTESEASVDETSEKTIAKDL 5894

  Fly   432 QKMAS---SQELQPKEELTPQSSLSLND----LIRTLRPNEQ-------------QIIPQIDSDY 476
            ....|   :..:..|:..||:.:.|::.    .:.:::|:|:             .|:|.::|:.
Zfish  5895 VSPTSLLHTTSISDKDFTTPKETTSMSSSTDVAVTSIKPSEKTTGRDIFSTSRIASILPSLESES 5959

  Fly   477 S 477
            |
Zfish  5960 S 5960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nw	NP_001027435.2	CLECT	31..176	CDD:153057	30/145 (21%)
vcana	XP_021331663.1	Ig	36..148	CDD:325142
		Link_domain_CSPGs_modules_1_3	147..241	CDD:239594
		Link_domain_CSPGs_modules_2_4	249..343	CDD:239597
		Herpes_BLLF1	<5897..>6290	CDD:330317	11/64 (17%)
		EGF	8622..8652	CDD:306513
		EGF_CA	8656..8692	CDD:238011
		CLECT_CSPGs	8698..8821	CDD:153058
		CCP	8825..8881	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1509611at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920