DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pif1B and ACAN

DIOPT Version :9

Sequence 1:	NP_001027155.1	Gene:	Pif1B / 3771985	FlyBaseID:	FBgn0046874	Length:	1041	Species:	Drosophila melanogaster
Sequence 2:	NP_001356197.1	Gene:	ACAN / 176	HGNCID:	319	Length:	2568	Species:	Homo sapiens

Alignment Length:	797	Identity:	150/797 - (18%)
Similarity:	244/797 - (30%)	Gaps:	227/797 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 EPEKASSFKSAITACTKELLDPCTCGAHPPYWAGQSNLVTGPSYSRAMDPSSSTLAPLHRPGASK 193
            :|.....|..| |:...:|:...|.|      :|:|:.:|      .:|.|...:||.
Human  1798 QPSGLPGFSGA-TSGVPDLVSGTTSG------SGESSGIT------FVDTSLVEVAPT------- 1842

  Fly   194 GSFGRSKSLASLPSKSNPPTQSGVTWLSALKDPESTCCSSKEDERPACTCNATQTNQDPSMSSLP 258
             :|...:.|.|:.....|..::.::..|.:.|.......:.:        ::..|:|.|..|.||
Human  1843 -TFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVD--------SSGFTSQTPEFSGLP 1898

  Fly   259 QSHPNYRSMTSKSSNFRAPNPRNQPS---FGPGDETSATTRSQSIVGQVTCLCASEHQPTKAFVS 320
            .   ....::.:||  ||....:.||   :|.|..:|..|                        .
Human  1899 S---GIAEVSGESS--RAEIGSSLPSGAYYGSGTPSSFPT------------------------V 1934

  Fly   321 SLADRECPNEIQIAPCPSTRIHHPSGFAQFTDCQNSQGDPSTSFRSRKVSVKGQEEFCDCDASDN 385
            ||.||.....:..||........|||..:.:...:...|.|           |:.        ..
Human  1935 SLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMS-----------GEH--------SG 1980

  Fly   386 FSELSDPIQTSLHTHRSLSGGSCLCNDDADPPKEPEKATCVSKQCQCSSNDELQGMQSAQAGTGY 450
            |.:||           .|..|  |.....:||..|..:.      ..:|...:.|..|...||..
Human  1981 FLDLS-----------GLQSG--LIEPSGEPPGTPYFSG------DFASTTNVSGESSVAMGTSG 2026

  Fly   451 QT---PEDLCGNRAMACCSRKERILMLMEKLTSPGCDCGISRPCLTQQLFRELTLLLRSEKDDAV 512
            :.   ||                    :..:||...: |::.|.::|:|.:.
Human  2027 EASGLPE--------------------VTLITSEFVE-GVTEPTISQELGQR------------- 2057

  Fly   513 APADEASPPCL----TFDECCTAQHAGNGEGDPVEKPPSKRELQRVECFHQLEEYLCKCFLPPAE 573
                   ||..    .|:.......||:..|.....|.|..|:..|               |.:.
Human  2058 -------PPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSV---------------PESS 2100

  Fly   574 PQIPETDIYAFELDPDFPPEPEPKSPKENDNMQPCQCPEQFFDIGNALTCSGDGLDDDFFRDCED 638
               .||..|.   :..|.....|::.:|:............|...|....||.|:........|.
Human  2101 ---SETSAYP---EAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEG 2159

  Fly   639 DEEVKKFESKDDGKATTEPDL--------CQSLKAFIDK-ELQEILAEEANKEGEEVEEKTPSTV 694
            :.......|   |::||..|:        ..:..|..|: |:...|:...::.|..:....|.:.
Human  2160 EASAAPEVS---GESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPESE 2221

  Fly   695 LREICERP----------TTVASPEEEEKPEQIECPF-AGMVSCPPWTTQQTDWAAFPYNL---D 745
            ..:..:||          :.:.|.||....|....|. |.:.:.|.|..:....||.|...   :
Human  2222 WTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEE 2286

  Fly   746 PCAQ---KESPSPAPRGPRTGLLPEGPLSPDMR-NLCEQLLRKALKDCGLCGGDDVYSC------ 800
            ||..   ||:     .|....|.|.|....... ::.|.|....|.........|.::|
Human  2287 PCGAGTCKET-----EGHVICLCPPGYTGEHCNIDIDECLSSPCLNGATCVDAIDSFTCLCLPSY 2346

  Fly   801 EDDVCEECALNCEE--------CPEDCP-LEKCEECDDECPPEQQGCLCCHCRALICDEECKTVA 856
            |.|:||.....|||        |....| .|...:.:..|..:|.     |..:::..||.:.|.
Human  2347 EGDLCEIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQS-----HLSSIVTPEEQEFVN 2406

  Fly   857 NTLRS----GMCDPLCE 869
            |..:.    |:.|...|
Human  2407 NNAQDYQWIGLNDRTIE 2423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pif1B	NP_001027155.1	None
ACAN	NP_001356197.1	Ig_Aggrecan	43..154	CDD:143308
		G1-A	48..141
		G1-B	152..247
		Link_domain_CSPGs_modules_1_3	153..247	CDD:239594
		G1-B'	253..349
		Link_domain_CSPGs_modules_2_4	254..349	CDD:239597
		G2-B	477..571
		Link_domain_CSPGs_modules_1_3	478..572	CDD:239594
		G2-B'	578..673
		Link_domain_CSPGs_modules_2_4	579..674	CDD:239597
		KS	677..849
		PHA03307	716..>975	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	734..979
		12 X 6 AA approximate tandem repeats of E-[GVE]-P-[SFY]-[APT]-[TSP]	773..844
		CS-1	852..1612
		35 X 19 AA approximate tandem repeats of E-[IVDG]-[LV]-[EV]-[GTI]-[STA]-[ATV]-[SP]-[GA]-[VIFAD]- [GEDL]-[DE]-[LVI]-[SG]-[GERK]-[LV]-P-S-G	942..1612
		PRK15387	<1433..>1614	CDD:185285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1499..1526
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1543..1649
		CS-2	1613..2277		114/639 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1687..1772
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1784..1827		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1883..1902		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1948..1977		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2048..2204		35/199 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2249..2281		8/31 (26%)
		EGF_CA	2283..2313	CDD:238011	8/34 (24%)
		EGF_CA	2316..2352	CDD:238011	7/35 (20%)
		CLECT_CSPGs	2358..2481	CDD:153058	16/71 (23%)
		CCP	2485..2541	CDD:153056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2548..2568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28NBU
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900