DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18749 and CG34345

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001097101.1	Gene:	CG34345 / 5740402	FlyBaseID:	FBgn0085374	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	170/518 - (32%)
Similarity:	265/518 - (51%)	Gaps:	59/518 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YILKKLTFIGFLSACFINCQGFVNSNPKKS---------YAASTMELMKLLEVEDELVDNLKGYV 57
            |||.....:...:.|          ..||:         |:.|...|.:|.|:|:..:::|..||
  Fly     8 YILLNWILLFLFTVC----------KAKKAENDVVQEVIYSNSIRALSELREIENSYMEHLNNYV 62

  Fly    58 KTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALG 122
            ..|:.|...:...:..::...::.|.|...|:.||||||.|:.|.|..|.|...| :|.:.|...
  Fly    63 SFLQQKIKTLRIFINSLTPNYLDHKVDRYKYVSNPLNSFGLLRRAHQDWPKLIAY-LKDQGNIKV 126

  Fly   123 HIENARLMRKMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEF 187
            .||....:....|.::|:::|..|:..:.:|||||..::|.|.:|| .|..:.::|.|||||.::
  Fly   127 DIEEMNKLINRTPHANDMEEALMGMDRIEHFYDLKSSDMAQGLVAG-QQLSSRMSASDCLALADY 190

  Fly   188 GVQNQKDDLAEAWYNLSLTRF----DNIIEKY------QVHKAWALLLAKN---KQLTEAFQHFE 239
            ..:..:...|..||.::|:.|    :||..|:      ::.|.:.:...:.   :.||:..:...
  Fly   191 MYKRSEFRRAAEWYRIALSVFTKPKNNIAFKFYAPKRKELEKMFVISRLQEGSVENLTDCLKELS 255

  Fly   240 NKPEGIVASNEVIHFEGVLATT---QNCTAVVQKPSKKLHCRYNTSTTPFTRIAPLKMEELGLDP 301
            ..|     :|.::|.....:.|   |.|.... .|..:|.||||::||||.||||||.||:..||
  Fly   256 QDP-----NNSLVHLRPRKSPTMIEQGCQGKF-PPGPQLVCRYNSTTTPFMRIAPLKEEEISRDP 314

  Fly   302 YMVVFHDVIYDTEIDGMLN----------SSDFGLSESVSGLKSEVRTSKDSHIVDAKTLNERVT 356
            .:.::||||||:||..:.|          ::::...:.|:.|.....|..|...:| |||..|:.
  Fly   315 LIWLYHDVIYDSEIAQLTNVTREEMILGTTTNYTTPDRVNRLFHIKVTDDDGGKLD-KTLVNRMA 378

  Fly   357 DMTGLSMEMSDPFSLINYGLGGHFILHHDFHE---YTNTTRLKQGDRIATVLFYLREVDSGGATV 418
            |::||.:..:...:.|||||||:|..|.|:.:   |...|  ::|||:.|.|||:.:|..||.|:
  Fly   379 DISGLDVGNTTTLARINYGLGGYFQEHSDYMDIKLYPELT--EEGDRLMTFLFYMTDVPVGGTTI 441

  Fly   419 FPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTPCMK 481
            ||...:.:.||||||:|||||||:|..|..|.|..||.|.||::||.|.:....|||..||.|
  Fly   442 FPGAQLAIQPKKGSALFWYNLHNNGDPNLLTRHAVCPTIVGSRWVLVKSMLNYEQMFKKPCYK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	40/130 (31%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	65/166 (39%)
CG34345	NP_001097101.1	P4Ha_N	40..170	CDD:285528	40/130 (31%)
CG34345	NP_001097101.1	P4Hc	324..489	CDD:214780	66/167 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461740
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890