DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18749 and P4HTM

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_808807.2	Gene:	P4HTM / 54681	HGNCID:	28858	Length:	563	Species:	Homo sapiens

Alignment Length:	289	Identity:	66/289 - (22%)
Similarity:	98/289 - (33%)	Gaps:	130/289 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 DTEIDGMLNSSDFG------LSESVSGLKSE----VRTSKDS---------HIVDAKTLNERVTD 357
            |.:.||:|:..:|.      ..:.:...|:|    ||.|..:         ||:  :.:.:||..
Human   237 DPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIM--RAIRQRVLR 299

  Fly   358 MTGLS---MEMSDPFSLINYGLGGHFILHHDFHE-YTNT----TRLKQGDRI------------- 401
            :|.||   :|:|:|..::.||.|||:..|.|... |..|    |:|...:.:
Human   300 LTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNW 364

  Fly   402 --------------------------------------------------------ATVLFYLRE 410
                                                                    .||||||..
Human   365 GLPSILRPGTPMTQAQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNN 429

  Fly   411 VDSGGATVFPML---------------------------NITVMPKKGSAVFWYNLHNSGA---- 444
            |..||.||||:.                           |:.|.|::|:||||||....|.
Human   430 VTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVG 494

  Fly   445 -VNSKTLHTACPVISGSKYVLTKWINELP 472
             |:..:||..|.|..|:|::...|||..|
Human   495 DVDDYSLHGGCLVTRGTKWIANNWINVDP 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	61/281 (22%)
P4HTM	NP_808807.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		EF-hand_7	192..252	CDD:290234	5/14 (36%)
		EFh	194..252	CDD:238008	5/14 (36%)
		P4Hc	246..519	CDD:214780	58/274 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149312
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740