Protein Alignment CG18749 and P4HA1

DIOPT Version :9

• Sequence 1: NP_001027154.1
• Gene: CG18749 / 3771984
• FlyBaseID: FBgn0042182
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_000908.2
• Gene: P4HA1 / 5033
• HGNCID: 8546
• Length: 534
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 164/559 - (29%)
• Similarity: 250/559 - (44%)
• Gaps: 115/559 - (20%)

  Fly     2 YILKKLTFIGFLSACFINCQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNL 66
            |||    .||.|....:...||.         .|..::..|:..|.:||.:||.|:|..:.|...
Human     4 YIL----IIGILLPQSLAHPGFF---------TSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQ 55

  Fly    67 MERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMR 131
            :::....:.|.......|.|.::|:|:|:|:|:.||:|.|.:.....:|..::  |.|.|..:.|
Human    56 IKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSD--GFISNLTIQR 118

  Fly   132 KMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQNQKDDL 196
            :..|...|...|.:.:..|...|:|..:.::.|||.|.... :.|||.||..||:..........
Human   119 QYFPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHK-SFLTAEDCFELGKVAYTEADYYH 182

  Fly   197 AEAWYNLSLTRFD----NIIEK--------YQVHKAW----ALLLAKNKQLTEAFQHFENKPEGI 245
            .|.|...:|.:.|    :.|:|        |.|::..    ||||.|        :..|..||..
Human   183 TELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTK--------KLLELDPEHQ 239

  Fly   246 VASNEVIHFEGVLA-------------TTQNCT------AVVQKP-------------------- 271
            .|:..:.:||.::|             :.|..|      ||...|
Human   240 RANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKMTPRR 304

  Fly   272 SKKLHCRYNT-STTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEID------------------- 316
            .|||.|||:. :..|...:||.|.|:....|.::.|||:|.|.||:
Human   305 QKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPE 369

  Fly   317 -GMLNSSDFGLSES--VSGLKSEVRTSKDSHIVDAKTLNERVTDMTGLSMEMSDPFSLINYGLGG 378
             |.|.::.:.:|:|  :||.::.|          ...:|.|:.|:|||.:..::...:.|||:||
Human   370 TGKLTTAQYRVSKSAWLSGYENPV----------VSRINMRIQDLTGLDVSTAEELQVANYGVGG 424

  Fly   379 HFILHHDFHEYTNTTRLKQ---GDRIATVLFYLREVDSGGATVFPMLNITVMPKKGSAVFWYNLH 440
            .:..|.||.........|:   |:||||.|||:.:|.:|||||||.:..:|.||||:|||||||.
Human   425 QYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLF 489

  Fly   441 NSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTPC 479
            .||..:..|.|.||||:.|:|:|..||::|..|.|..||
Human   490 ASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPC 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	34/130 (26%)
		P4Hc	314..468	CDD:214780	64/178 (36%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	23/88 (26%)
		TPR	205..238		9/40 (23%)
		P4Hc	345..518	CDD:214780	66/182 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910