Protein Alignment CG18749 and PH4alphaNE2

DIOPT Version :10

• Sequence 1: NP_001027154.1
• Gene: CG18749 / 3771984
• FlyBaseID: FBgn0042182
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_733378.1
• Gene: PH4alphaNE2 / 43628
• FlyBaseID: FBgn0039783
• Length: 542
• Species: Drosophila melanogaster
• Alignment Length: 546
• Identity: 168/546 - (30%)
• Similarity: 259/546 - (47%)
• Gaps: 90/546 - (16%)

  Fly     6 KLTFIG--FLSACFINCQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLME 68
            :|..:|  :||..|...:   .:|.::.:|.|.:.:..:|.:||:||.|::...:.|..|...::
  Fly     5 RLVLLGMLYLSLSFGQLR---ENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIK 66

  Fly    69 RSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIE----NARL 129
            ..:..|.:...|.||..|.: .||:::|.||..:.::|..|..|.    ...:|..|    ::|:
  Fly    67 WGVFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYL----ETPVGQEELFFVDSRM 126

  Fly   130 MRKMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQNQKD 194
              .:||...|...|..||..:...|.:...::|.|.|.|. |..:.|...||||:|...:.|.:.
  Fly   127 --PLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGV-QYNSSLKPIDCLAIGLHLMNNSRW 188

  Fly   195 DLAEAWYNLSLTRFD----------------------------------NIIEKYQVHKAWALLL 225
            ..||.|.:.|:..:|                                  ..::.|||    ||.|
  Fly   189 YAAEQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQV----ALKL 249

  Fly   226 A-KNKQLTEAFQHFENKP------EGIVASNEVIHFEGVLATTQNCTAVVQKPS--KKLHCRYNT 281
            : .:.::.|.::..|.:.      |.|....:..|...||...  |:...|.|.  ..|:|.||.
  Fly   250 SPHDPEIYEEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPC--CSGRCQVPRNLSNLYCVYNH 312

  Fly   282 STTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSDFGLSES------VSGLKSEVRTS 340
            .|:||.::||:|.|.|.:||::|:.||:|...|...:..||...:..|      .|..:::|.|.
  Fly   313 VTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTY 377

  Fly   341 KDSHIV--------DAKTLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDF-----HEYTNT 392
            :.|..|        ..|.:.||:.|.|||.|..::.:.:|||||||.|..|.|.     :.:..|
  Fly   378 RTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGT 442

  Fly   393 TRLKQGDRIATVLFYLREVDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVI 457
            :     |||||.||||.||..||.|.||.||:||.|:.|||:|||||...|..:..:|||.||||
  Fly   443 S-----DRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVI 502

  Fly   458 SGSKYVLTKWINELPQMFVTPCMKDS 483
            .|||:|::||||::.|.|..||::.|
  Fly   503 VGSKWVMSKWINDMGQEFTRPCVESS 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..168	CDD:462433	35/136 (26%)
		P4Hc	314..468	CDD:214780	70/172 (41%)
PH4alphaNE2	NP_733378.1	P4Ha_N	33..163	CDD:462433	35/136 (26%)
		TPR repeat	175..200	CDD:276809	9/24 (38%)
		TPR_16	176..254	CDD:433202	15/81 (19%)
		NrfG	217..>260	CDD:443378	7/46 (15%)
		TPR repeat	219..249	CDD:276809	5/33 (15%)
		P4Hc	342..513	CDD:214780	70/175 (40%)