DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18749 and PH4alphaNE2

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_733378.1	Gene:	PH4alphaNE2 / 43628	FlyBaseID:	FBgn0039783	Length:	542	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	168/546 - (30%)
Similarity:	259/546 - (47%)	Gaps:	90/546 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KLTFIG--FLSACFINCQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLME 68
            :|..:|  :||..|...:   .:|.::.:|.|.:.:..:|.:||:||.|::...:.|..|...::
  Fly     5 RLVLLGMLYLSLSFGQLR---ENNAQQRFARSVVNMDDMLNLEDDLVSNVEKLAEALARKAKTIK 66

  Fly    69 RSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIE----NARL 129
            ..:..|.:...|.||..|.: .||:::|.||..:.::|..|..|.    ...:|..|    ::|:
  Fly    67 WGVFKMMKRRQEYKSSMEIF-ANPIDTFSLIRHMQSNWLMWLLYL----ETPVGQEELFFVDSRM 126

  Fly   130 MRKMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQNQKD 194
              .:||...|...|..||..:...|.:...::|.|.|.|. |..:.|...||||:|...:.|.:.
  Fly   127 --PLLPKYFDFIDAAEGIRKMQATYQMFSSDIAKGLLDGV-QYNSSLKPIDCLAIGLHLMNNSRW 188

  Fly   195 DLAEAWYNLSLTRFD----------------------------------NIIEKYQVHKAWALLL 225
            ..||.|.:.|:..:|                                  ..::.|||    ||.|
  Fly   189 YAAEQWISASIEAYDQKSSQTDMELLRGPKLADLCRILGQVQMKQRNHEGALQAYQV----ALKL 249

  Fly   226 A-KNKQLTEAFQHFENKP------EGIVASNEVIHFEGVLATTQNCTAVVQKPS--KKLHCRYNT 281
            : .:.::.|.::..|.:.      |.|....:..|...||...  |:...|.|.  ..|:|.||.
  Fly   250 SPHDPEIYEEYRILEKRDLTLSDIEPIEQDKDNSHERLVLPPC--CSGRCQVPRNLSNLYCVYNH 312

  Fly   282 STTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSDFGLSES------VSGLKSEVRTS 340
            .|:||.::||:|.|.|.:||::|:.||:|...|...:..||...:..|      .|..:::|.|.
  Fly   313 VTSPFLQLAPIKTEILSIDPFVVLLHDMISQKESTLIRTSSKEHMLPSATTDPDASDDETQVDTY 377

  Fly   341 KDSHIV--------DAKTLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDF-----HEYTNT 392
            :.|..|        ..|.:.||:.|.|||.|..::.:.:|||||||.|..|.|.     :.:..|
  Fly   378 RTSKSVWYSSDFNDTTKKITERLGDATGLDMNSTEFYQVINYGLGGFFETHLDMLLSEKNRFNGT 442

  Fly   393 TRLKQGDRIATVLFYLREVDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVI 457
            :     |||||.||||.||..||.|.||.||:||.|:.|||:|||||...|..:..:|||.||||
  Fly   443 S-----DRIATTLFYLNEVRQGGGTYFPRLNLTVFPQPGSALFWYNLDTKGNDHMGSLHTGCPVI 502

  Fly   458 SGSKYVLTKWINELPQMFVTPCMKDS 483
            .|||:|::||||::.|.|..||::.|
  Fly   503 VGSKWVMSKWINDMGQEFTRPCVESS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	34/134 (25%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	70/172 (41%)
PH4alphaNE2	NP_733378.1	P4Ha_N	33..161	CDD:285528	34/134 (25%)
		TPR repeat	175..200	CDD:276809	9/24 (38%)
		TPR_16	176..254	CDD:290168	15/81 (19%)
		TPR repeat	219..249	CDD:276809	5/33 (15%)
		TPR_2	220..253	CDD:285020	6/36 (17%)
		P4Hc	342..513	CDD:214780	70/175 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461741
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890