DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18749 and CG15539

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	158/503 - (31%)
Similarity:	256/503 - (50%)	Gaps:	63/503 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NSNPK---KSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYE 86
            :|.||   .:||.|..::.||::.|..|::.|:.:...|:.:.:.:|..|        || :||:
  Fly    20 HSKPKILENNYAISIYDMSKLIDYEHYLLNILQKFANALQKRVDTLEYYL--------EM-TDYD 75

  Fly    87 ---SYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGH-IENARLMRKMLPTSSDLQQACRGI 147
               :...:|:..||:..|||:.:..|..:   :|....|. :::...:...:||..|:::|.||:
  Fly    76 REKNLAEDPIKHFRITRRLHSDYVNWVWF---MEEQPWGTLVKDIIAIAPEMPTLKDVEEAIRGL 137

  Fly   148 HDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQNQKDDL-AEAWYNLSLTRFDNI 211
            ..:.:.|.|...|:|.|.|..... .|.|....|:.:....| |.||.: |:.|..:.|..::..
  Fly   138 RLIQWTYSLPTAEMAKGVLQDIHH-NTSLDGMQCITIARHMV-NYKDFIRAKEWLMVGLKMYEAD 200

  Fly   212 IEKYQVHKAWALLLAKNKQLTEAFQH---------------FENKPEGIVASNEV------IHFE 255
            .|...::....:.|....:|....|.               .:|.||.:.....:      |...
  Fly   201 EEIEYIYSQLGMPLVDFYELFVEIQDELGSRYLAMSELQLAIKNWPEKVSLQRALSRLKMNIRIG 265

  Fly   256 GVLATTQN--------CTAVVQKPSKKLHCRYNTSTTPFTRIAPLKMEELGLDPYMVVFHDVIYD 312
            ...|..:|        |.:...:|:.||:|.|.|:::.|.|:||||||.|.||||||:||||:.|
  Fly   266 KEPAEKKNKSKRVYKKCCSSECRPTAKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSD 330

  Fly   313 TEIDGMLNSSDFGLSESVSGLK------SEVRTSKDSHIVDAKTLNERVT----DMTGLSMEMSD 367
            .:|..:.|.:...|:.:|:..|      ...||:|.:.:|:...|.:|::    |||...:..:|
  Fly   331 KDIVSIRNLTKGKLARTVTVSKDGNYTEDPDRTTKGTWLVENNALIQRLSQLTQDMTNFDIHDAD 395

  Fly   368 PFSLINYGLGGHFILHHDFHEYTNTTRLKQGDRIATVLFYLREVDSGGATVFPMLNITVMPKKGS 432
            ||.::|||:||.:.:|.||.|.......  .|||||.:|||.:|..||||:||.|.::|.|||||
  Fly   396 PFQVLNYGIGGFYGIHFDFLEDAELDNF--SDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGS 458

  Fly   433 AVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTPCM 480
            |:.||||.:.|..:::|.|:|||.:.||::|:||||||..|:|..||:
  Fly   459 ALLWYNLDHKGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFRRPCL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	33/134 (25%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	64/163 (39%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/134 (25%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	65/166 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461724
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890