DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18749 and PH4alphaNE1

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_733374.1	Gene:	PH4alphaNE1 / 43625	FlyBaseID:	FBgn0039780	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	157/528 - (29%)
Similarity:	232/528 - (43%)	Gaps:	83/528 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FINCQGFVNSNPKKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEM 81
            |:..||.:.|:    |.:|...|..||..|..|...|:..|..::.....:|..|..:.:|:...
  Fly    12 FLLAQGSLASD----YFSSITGLEDLLHTEQYLTRELRSKVNAIQTALQQLESELSSIEKEHTMA 72

  Fly    82 KSDYESYLGNPLNSFRLIHRLHTSWR----KWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQ 142
            .||.|:||.||:|.:||:.||||.|.    :....|.::..||      .|......|:..|::.
  Fly    73 ASDTENYLTNPVNVYRLMKRLHTDWSLMEGRVQLMAEEMNFNA------TREYGLSYPSQEDVEG 131

  Fly   143 ACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQNQKDDLAEAWYNLSLTR 207
            |...:..|...|.|...::|.|.|.|... |:.::..||..||:...:.:..:..:.|...|:.|
  Fly   132 AALALVRLQSTYKLDVAQVAQGILNGVKY-GSDMSWQDCFELGQQLFEMEDYNNTKVWLRESMER 195

  Fly   208 FDNIIEKYQVH---------------KAWALLLAKNKQLTEAFQ----------------HFENK 241
            ..........|               :|.|..|.:......||:                |..:|
  Fly   196 LRRQTSHAPSHLAPTSGPDTVTLNKMEATAKSLFQLGDFDTAFELSQRVLQFDPKRIRNWHLGDK 260

  Fly   242 ----PEGI------------VASNEVIHFEGVLATTQNCTAVVQK-PSKKLHCRYNTSTTPFTRI 289
                ||.|            ..|.|...:|.|      |...|.. ..::|.|||:....|:..:
  Fly   261 GTAPPEDIDDVYLPKHSDSYSLSQEFAKYEKV------CRGEVHPIVRQELRCRYSRGNHPYRFL 319

  Fly   290 APLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSDFGLSES-VSGL------KSEVRTSK------ 341
            ||||:||..||||:..|||::...:|..:...:...:..| |:.|      ||..|.||
  Fly   320 APLKLEEHSLDPYVATFHDILSPGKISQLREMAVPRMHRSTVNPLPGGQLKKSAFRVSKNAWLAY 384

  Fly   342 DSHIVDAKTLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDFHEYTNTTRLKQGDRIATVLF 406
            :||......|.: :.|.|||.....:...:.|||:|||:..|.||....|....::|:||||.:|
  Fly   385 ESHPTMVGMLRD-LKDATGLDTTFCEQLQVANYGVGGHYEPHWDFFRDPNHYPAEEGNRIATAIF 448

  Fly   407 YLREVDSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINEL 471
            ||.||:.||||.||.|:|.|.|:.|:.:||||||.|...:.:|.|..|||:.|||::...||:|:
  Fly   449 YLSEVEQGGATAFPFLDIAVKPQLGNVLFWYNLHRSLDKDYRTKHAGCPVLKGSKWIGNVWIHEV 513

  Fly   472 PQMFVTPC 479
            .|.|..||
  Fly   514 TQTFARPC 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	38/134 (28%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	62/166 (37%)
PH4alphaNE1	NP_733374.1	P4Ha_N	26..155	CDD:285528	38/134 (28%)
PH4alphaNE1	NP_733374.1	P4Hc	341..511	CDD:214780	63/170 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461810
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890