DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18749 and CG18233

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_649044.3	Gene:	CG18233 / 40025	FlyBaseID:	FBgn0036795	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	170/521 - (32%)
Similarity:	274/521 - (52%)	Gaps:	75/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SACFINCQGFVNSNP-----KKSYAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLID 73
            :|..|..|...:::|     :|.|::|.:.|:|||::|.|.:.|...|...|:.|.:.:...|..
  Fly     8 AAVLILVQSIHSTDPNDFLNRKYYSSSVLGLVKLLKMEQEFMVNFSIYANILQEKVDNLNIFLDA 72

  Fly    74 MSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKML---P 135
            :.|.|.:..::.|.::.||||:|.||.||:..|.|...|..|    .|| :|....|:.::   |
  Fly    73 LKRPNHKTHNEREKFVSNPLNAFGLIRRLNQDWPKLQNYTQK----PLG-LEQLTAMQDIVSAAP 132

  Fly   136 TSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTGLTAYDCLALG--EFGVQNQKDDLAE 198
            .|.|:.:..:.:|.:...|||:|:::|.| |...::....|...|||||.  :|.:...|..|
  Fly   133 ESFDMNEKLKAMHRIETTYDLQPKDIAKG-LLQRTEFNYRLLFRDCLALAYHKFEIGEFKRSL-- 194

  Fly   199 AWYNLSL-------TRFDNIIEKYQVHKAWALLLAK------NKQLT-EAFQHFENKP------- 242
            .|:..:|       ....|.:::.:: |.:|..:||      |:.|| |......|..
  Fly   195 LWFQEALKLSTDGSLEIMNRLKEIEL-KGFATAVAKRSIYLSNQGLTNETIDDMANSQLQDAKLM 258

  Fly   243 --EGIVAS--NEVIHFEGVLATTQN---CTAVVQKPSKKLHCRYNTSTTPFTRIAPLKMEELGLD 300
              |.:::|  .:.|:.:.....|.:   |..:..|.| .|.||||:||..|.::|||||||:..|
  Fly   259 DLEQLISSELKQWINDDSTTPPTDHNLGCRGLFPKKS-NLVCRYNSSTNAFLKLAPLKMEEISRD 322

  Fly   301 PYMVVFHDVIYDTEIDGMLNSSDFGLSESVSGLKS-----EVRT-----SKDSHIVDAKTLNERV 355
            ||:|:||:||.|.:|:.|...    ::|..:|..|     |:.:     .|:|..  :|.:|:|:
  Fly   323 PYIVMFHEVISDKDIEEMKGE----ITEMENGWTSLGDPKEIVSRVYWIRKESSF--SKRINQRI 381

  Fly   356 TDMTGLSMEMSDPFSLINYGLGGHFILHHDFHEYTNTTRLKQ-------GDRIATVLFYLREVDS 413
            :||||..:|......|.|:|:||:|..|:||:    |.|||:       ||||.:::||..||..
  Fly   382 SDMTGFKLEEFPAIQLANFGVGGYFKPHYDFY----TDRLKEVDVNNTLGDRIGSIIFYAGEVSQ 442

  Fly   414 GGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTP 478
            ||.||||.|.:.|.||||:|:||:|..:....:.::||:.|||:.||::.:|||::..||:||.|
  Fly   443 GGQTVFPDLKVAVEPKKGNALFWFNAFDDSTPDPRSLHSVCPVLVGSRWTITKWLHYAPQLFVKP 507

  Fly   479 C 479
            |
  Fly   508 C 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	42/133 (32%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	62/170 (36%)
CG18233	NP_649044.3	P4Ha_N	34..163	CDD:285528	42/134 (31%)
		ATP-synt_B	<198..278	CDD:304375	14/80 (18%)
		P4Hc	333..498	CDD:214780	64/174 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461794
Domainoid	1	1.000	91	0.514	Domainoid score	I2609
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.890