DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18749 and p4ha2

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	566	Identity:	149/566 - (26%)
Similarity:	251/566 - (44%)	Gaps:	122/566 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYILKKLTFIGFLSACFINCQGFVNSNPKKSYAASTM-ELMKLLEVEDELVDNLKGYVKTLKMKF 64
            :::|..|:|                |:|.::...::: ::..|:..|.|||.:||.|::..:.|.
Zfish     6 VFLLSTLSF----------------SSPTRAEIFTSIGQMTNLIFTERELVQSLKEYIQAEEQKL 54

  Fly    65 NLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARL 129
            ..:......:.:......||.|.:|.:|:|:::|:.||:|.|.:  ..::.:::.:.|.|.|..:
Zfish    55 ETVRSWANKLDKLTRTSTSDPEGFLAHPVNAYKLMKRLNTEWSE--LESLVLQDPSDGFISNMSV 117

  Fly   130 MRKMLPTSSDLQQACRGIHDLMYFYDLKPEELAAGNLAGYSQPGTG------LTAYDCLALGEFG 188
            .|:..|...|.:.|.:.:..|...|.|..|..:.|.|.|..| .:|      ||..||..:|:..
Zfish   118 HRQYFPDEEDEKGAAKALLRLQDTYKLDAESFSKGKLPGQRQ-HSGVRYNALLTVDDCFDMGKMA 181

  Fly   189 VQNQKDDLAEAWYNLSLTRFDNIIE------------KYQVHKAWAL---------LLAKNKQLT 232
            ..:.....:..|...||.:.|:..|            .|.|::...|         |||.:....
Zfish   182 YNDNDYYHSVLWMQQSLRQMDSGEEAKTPKADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQ 246

  Fly   233 EA---FQHFE----------------------------NKPEGIVASNE----VIHFEGVLATTQ 262
            .|   .::||                            .:|:..:...|    :...|||..||
Zfish   247 RAGGNLRYFERLLSKELQDSGQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTT- 310

  Fly   263 NCTAVVQKPSKKLHCRY-NTSTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEID---------- 316
                   |...:|.||| :.:..|...:.|:|.|:....|::|.|.:.:.|.||.
Zfish   311 -------KRQSRLFCRYRDGNRNPRLLLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKL 368

  Fly   317 ----------GMLNSSDFGLSESVSGLKSEVRTSKDSHIVDAKTLNERVTDMTGLSMEMSDPFSL 371
                      |:|..:.:.:|:| :.|:.|     |..::  ..:|:|:.|:|||:::.::...:
Zfish   369 ARATVRDPKTGVLTVAHYRVSKS-AWLEGE-----DDPVI--ARVNQRIEDITGLTVDTAELLQV 425

  Fly   372 INYGLGGHFILHHDFHEYTNTTRLKQ---GDRIATVLFYLREVDSGGATVFPMLNITVMPKKGSA 433
            .|||:||.:..|.||.........|.   |:|:||.|.|:.:|::|||||||....:|.|:||:|
Zfish   426 ANYGVGGQYEPHFDFSRKDEPDAFKSLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTA 490

  Fly   434 VFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTPC 479
            ||||||..||..:.:|.|.||||:.|||:|..|||:|..|.|..||
Zfish   491 VFWYNLFRSGEGDYRTRHAACPVLVGSKWVSNKWIHERGQEFRRPC 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	32/131 (24%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	62/176 (35%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	32/130 (25%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	64/180 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910