Protein Alignment CG18749 and P4HA3

DIOPT Version :10

• Sequence 1: NP_001027154.1
• Gene: CG18749 / 3771984
• FlyBaseID: FBgn0042182
• Length: 491
• Species: Drosophila melanogaster
• Sequence 2: NP_001275677.1
• Gene: P4HA3 / 283208
• HGNCID: 30135
• Length: 604
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 125/485 - (25%)
• Similarity: 216/485 - (44%)
• Gaps: 104/485 - (21%)

  Fly    27 NPKKSYA-----ASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSR---ENMEMKS 83
            :|:::.|     ::...:.:.|..|..|:..|:.|::.       .|..|.|::|   :.:.:..
Human    20 DPERAAARGDTFSALTSVARALAPERRLLGLLRRYLRG-------EEARLRDLTRFYDKVLSLHE 77

  Fly    84 DYESYLGNPLNSFRLIHRLHTSWRKWYQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIH 148
            |..:.:.|||.:|.||.||.:.||. ..::::...|.....:....:.:.||...||:.|.|.:.
Human    78 DSTTPVANPLLAFTLIKRLQSDWRN-VVHSLEASENIRALKDGYEKVEQDLPAFEDLEGAARALM 141

  Fly   149 DLMYFYDLKPEELAAGNLAGYSQPGTG--------------LTAYDCLALGEFGVQNQKDDLAEA 199
            .|...|.|..:.||    .|..|..||              ||..||..:|:  |.....|...|
Human   142 RLQDVYMLNVKGLA----RGVFQRVTGSAITDLYSPKRLFSLTGDDCFQVGK--VAYDMGDYYHA 200

  Fly   200 --WYNLSLTRF-----------DNIIEKYQVHKAWALLLAKN----KQLTEAFQHFENKPEGIVA 247
              |...:::.|           :..:|....|.|:|...|.|    ..|:..|..:  .|:....
Human   201 IPWLEEAVSLFRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLY--SPDNKRM 263

  Fly   248 SNEVIHFEGVLATTQN---CTAVVQKPS--------------------------KKLHCRYNTST 283
            :..|:.:|.:||.:.|   ..||:|:|:                          ..|:|.|.|::
Human   264 ARNVLKYERLLAESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNS 328

  Fly   284 TPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSSDFGLSESV--SG---LKSEVRTSKDS 343
            ..:..:.|::.|.:.|:||:.::||.:.|:|...:...::..|..||  ||   |:.|.|.||.:
Human   329 NAYLLLQPIRKEVIHLEPYIALYHDFVSDSEAQKIRELAEPWLQRSVVASGEKQLQVEYRISKSA 393

  Fly   344 HI---VDAK--TLNERVTDMTGLSMEMSDPFS----LINYGLGGHFILHHDFHEYTNTT---RLK 396
            .:   ||.|  |||.|:..:|||  ::..|::    ::|||:|||:..|.| |..:.::   |:|
Human   394 WLKDTVDPKLVTLNHRIAALTGL--DVRPPYAEYLQVVNYGIGGHYEPHFD-HATSPSSPLYRMK 455

  Fly   397 QGDRIATVLFYLREVDSGGATVFPMLNITV 426
            .|:|:||.:.||..|::||||.|...|::|
Human   456 SGNRVATFMIYLSSVEAGGATAFIYANLSV 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..168	CDD:462433	32/135 (24%)
		P4Hc	314..468	CDD:214780	47/130 (36%)
P4HA3	NP_001275677.1	P4Ha_N	58..160	CDD:462433	28/106 (26%)
		BepA	<188..289	CDD:443813	22/104 (21%)
		P4Hc	356..>478	CDD:214780	45/124 (36%)