DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18749 and dpy-18

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	NP_499464.1	Gene:	dpy-18 / 176569	WormBaseID:	WBGene00001077	Length:	559	Species:	Caenorhabditis elegans

Alignment Length:	527	Identity:	142/527 - (26%)
Similarity:	236/527 - (44%)	Gaps:	97/527 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 STMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLI 99
            |..::..|||.|..:...|..|:...:.:...:::...:.|::|.....:....:.||:|:|.||
Worm    21 SIADMQNLLETERNIPKILDKYIHDEEERLVQLKKLSEEYSKKNEISIENGLKDITNPINAFLLI 85

  Fly   100 HRLHTSWRKWYQYAIKVENNALGHI-----ENARLMRKMLPTSSDLQQACRGIHDLMYFYDLKPE 159
            .|....|:   :...|:..|..|::     :::..:|  .||:.||..|..|:..|...|.|..:
Worm    86 KRKIFDWK---EIESKMNANKAGNVVSSITDDSYGVR--YPTADDLSGAAIGLLRLQDTYRLDTK 145

  Fly   160 ELAAGNLAGYSQPGT-GLTAYDCL------------------------ALGE------------- 186
            :||.|.:  |:..|. ..:|.||.                        .||:
Worm   146 DLADGKI--YADQGNYTFSAKDCFEIARAAYNEHDFYHTVMWMEEAQRRLGDEVEPTVEVEDILE 208

  Fly   187 ---FGVQNQKD-----DLAEAWYNLSLTR---------FDNIIEKYQVHKAWALLLAKNKQLTEA 234
               |.:..|.:     .|.|..|.::.|.         :::::|:..|.::         .:.:.
Worm   209 YLAFALYKQNNLKHALKLTEELYKMNPTHPRAKGNVKWYEDLLEQEGVRRS---------DMRKN 264

  Fly   235 FQHFEN-KPEGIVASNEVIHFEGVLATTQNCTAVVQKPSKKLHCRYNTSTTPFTRIAPLKMEELG 298
            ....:| :|:.::.:.|...:|   |..:|...|.||...:|:|.|... .||...||:|:|...
Worm   265 LPPIQNRRPDSVLGNTERTMYE---ALCRNEVPVSQKDISRLYCYYKRD-RPFLVYAPIKVEIKR 325

  Fly   299 LDPYMVVFHDVIYDTEIDGMLNSSDFGLS-----ESVSG--LKSEVRTSKDSHIVD-----AKTL 351
            .:|..|:|.|||.|.|:..:...:...|:     :||:|  :.:..|.||.:.:.:     .:|:
Worm   326 FNPLAVLFKDVISDDEVAAIQELAKPKLARATVHDSVTGKLVTATYRISKSAWLKEWEGDVVETV 390

  Fly   352 NERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDF---HEYTNTTRLKQGDRIATVLFYLREVDS 413
            |:|:..||.|.||.::...:.|||:|||:..|.|.   .|..:...|..|:||||||||:.:...
Worm   391 NKRIGYMTNLEMETAEELQIANYGIGGHYDPHFDHAKKEESKSFESLGTGNRIATVLFYMSQPSH 455

  Fly   414 GGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFVTP 478
            ||.|||.....|::|.|..|:|||||:..|..|..|.|.||||:.|.|:|..|||:|....|..|
Worm   456 GGGTVFTEAKSTILPTKNDALFWYNLYKQGDGNPDTRHAACPVLVGIKWVSNKWIHEKGNEFRRP 520

  Fly   479 C-MKDSN 484
            | :|.|:
Worm   521 CGLKSSD 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	33/135 (24%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	61/168 (36%)
dpy-18	NP_499464.1	P4Ha_N	21..152	CDD:285528	33/135 (24%)
dpy-18	NP_499464.1	P4Hc	338..511	CDD:214780	63/172 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910