DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18749 and p4ha1

DIOPT Version :9

Sequence 1:	NP_001027154.1	Gene:	CG18749 / 3771984	FlyBaseID:	FBgn0042182	Length:	491	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	523	Identity:	155/523 - (29%)
Similarity:	238/523 - (45%)	Gaps:	97/523 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 YAASTMELMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSF 96
            :..|...::.||..|.:||.:||.|:|..:.|...:::....:.........|.|.|||:|:|:|
Frog    20 FFTSIGHMIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTATKDPEGYLGHPVNAF 84

  Fly    97 RLIHRLHTSWRKWYQYAIKVENNAL-----GHIENARLMRKMLPTSSDLQQACRGIHDLMYFYDL 156
            :|:.||:|.|       :|:||..|     |.|.|..:.|:..|...|...|.:.:..|...|:|
Frog    85 KLMKRLNTEW-------VKLENLILKDISDGFISNLTIQRQYFPNDEDQTGAAKALLRLQDTYNL 142

  Fly   157 KPEELAAGNLAGYSQPGTGLTAYDCLALGEFGVQNQKDDLAEAWYNLSLTRFD----NIIEK--- 214
            ..:.::.|||.|.... |.|||.||..||:....:......|.|...:|::.|    :.::|
Frog   143 DTDTISKGNLPGVKHK-TSLTAEDCFDLGKTAYTDADYYHTELWMEQALSQLDAGEESSLDKVMV 206

  Fly   215 -----YQVHKAWALLLAKNKQLTEAFQHFENKPEGIVASNEVIHF-------------EGVLATT 261
                 |.|::...|    :|.||...:..|..||....:..:.|.             ||....|
Frog   207 LDYLSYAVYQQGDL----DKALTLTKRSLELDPEHQRGNGNLRHIMSKESNKSSSSPSEGAELRT 267

  Fly   262 QN---------------C----TAVVQKPSKKLHCRY-NTSTTPFTRIAPLKMEELGLDPYMVVF 306
            :.               |    ..:..:..|:|.||| :....|...::|.|.|:....|.:|.:
Frog   268 RKGRPKDHLEKEKYEKLCRGEGVKMTSRRQKRLFCRYFDGKKDPLLILSPTKQEDEWDKPRIVRY 332

  Fly   307 HDVIYDTEID--------------------GMLNSSDFGLSES--VSGLKSEVRTSKDSHIVDAK 349
            ||:|.|.||.                    |:|.::.:.:::|  :||.:..|          ..
Frog   333 HDIISDEEISKVKELAKPRLRRATISNPITGVLETAQYRITKSAWLSGYEDPV----------VA 387

  Fly   350 TLNERVTDMTGLSMEMSDPFSLINYGLGGHFILHHDF---HEYTNTTRLKQGDRIATVLFYLREV 411
            .||.|:..:|||.|..::...:.|||:||.:..|.||   :|.....:|..|:|:||.|||:.:|
Frog   388 RLNRRIEGVTGLDMSTAEELQVANYGIGGQYEPHFDFLRKYEPDAFKKLGTGNRVATWLFYMSDV 452

  Fly   412 DSGGATVFPMLNITVMPKKGSAVFWYNLHNSGAVNSKTLHTACPVISGSKYVLTKWINELPQMFV 476
            ::|||||||.:...|.||||:|||||||..||..:..|.|.||||:.|:|:|..|||:|..|.|.
Frog   453 EAGGATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFR 517

  Fly   477 TPC 479
            .||
Frog   518 RPC 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18749	NP_001027154.1	P4Ha_N	35..166	CDD:285528	39/135 (29%)
CG18749	NP_001027154.1	P4Hc	314..468	CDD:214780	64/178 (36%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	28/93 (30%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	66/182 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100