Protein Alignment Msp300 and Clmn

DIOPT Version :9

• Sequence 1: NP_001188695.1
• Gene: Msp300 / 3771968
• FlyBaseID: FBgn0261836
• Length: 13540
• Species: Drosophila melanogaster
• Sequence 2: NP_444385.2
• Gene: Clmn / 94040
• MGIID: 2136957
• Length: 1052
• Species: Mus musculus
• Alignment Length: 991
• Identity: 201/991 - (20%)
• Similarity: 343/991 - (34%)
• Gaps: 286/991 - (28%)

  Fly  5923 FVEEPVVEVTTVVEEVTPETQPEPTPVSEVAPSQP-----LSWSSIV-SQTTEVTTNVTETRFTE 5981
            |:|:..|::.::             ..:|:|...|     |.|:.|: .|..|:|.|::.:
Mouse   103 FLEDSNVKLVSI-------------DAAEIADGNPSLVLGLIWNIILFFQIKELTGNLSRS---- 150

  Fly  5982 EPEDKKPLEEKPKKQKAKKEKKTKVVEA--PEPIVESAVPEAVVEPTVEVTFVEEPVVEVTTVVE 6044
                      .|....:.....|....:  |.|..|.:|..|          |::....:.|::.
Mouse   151 ----------SPSSSLSPGSGGTDSDSSYPPTPTTERSVAVA----------VKDQRKAIKTLLS 195

  Fly  6045 EVTPETQPEPTPVSEVAPSQPLSWSS---IVSQTTEITTNVTETRFTEEPEDKKPLEEKPKKQKS 6106
            .|..:|:.....|.:.|.    ||.|   .::....|..::.:.        |:.||:   ..:.
Mouse   196 WVQRKTRKYGVAVQDFAG----SWRSGLAFLAVIKAIDPSLVDM--------KQALED---STRD 245

  Fly  6107 KKEKKTKVVEAPEPIVESAVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVAPS 6171
            ..||...:......|.....||.::....:    |:.:|.......|..||.:||
Mouse   246 NLEKAFSIAHDSLHIPRLLEPEDIMVDMPD----EQSIVTYVAQFLERFPELEPE---------- 296

  Fly  6172 QPLSWSSIVSQTTEVTTNVTETRFTEEPEDK--------------KPLEEKPKKQKPKKEKKTKV 6222
                  ..|:...|.....|..|..|.|.::              ..:.::.....|.|......
Mouse   297 ------DFVNPDKEAPIESTFVRIKESPSEQGSRVLLLSENGERAYTVNQETSYPPPDKVFVCDQ 355

  Fly  6223 VEAPEPI-VESAVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQ--PEPTPVSEVAPSQP--- 6281
            :|:|... ::||....:.:.:.|  |:.|.:.:   |::..|.:|.  .||||.|.:..::.
Mouse   356 LESPTGFCLDSAPSHKLSDSSTE--FMHEIIDQ---VLQGSTGKTGSIAEPTPESSILSTRKDGR 415

  Fly  6282 LSWSSIVSQTTEVTTNV-------------TETRFTEEPEDKKPLEEKP--------KKQKSKKE 6325
            .|.|..|.:|.....::             ::.||...|:..|.|.::.        .|:|.|.|
Mouse   416 RSNSLPVKKTVHFEADLHKDASCSKDPFYSSDFRFEGSPKATKELSKQDGHVSLAEVSKEKKKSE 480

  Fly  6326 KKTKVV------EAPEPIVE--SAVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVS 6382
            ::.::|      :.||..|:  .|||:. .:|:.:.:|....|         .:|.:|.|..|
Mouse   481 QEARLVLEAASDKVPESTVDGLDAVPQD-AQPSQDSSFCNGTV---------ESPSSQGEKGP-- 533

  Fly  6383 EVAPSQPLSWSSIVSQTTEVTTNVTETRFTEEPEDKK------PLEEKPKKPKAKKEKKTKVVEA 6441
              .||.| ...::::.:||:...:    .|.||.||:      ||       ||.|..:..|..|
Mouse   534 --PPSSP-GDHTLLANSTELKVQL----LTVEPMDKEDYFECIPL-------KASKFNRDLVDFA 584

  Fly  6442 PEPIVESSVPEAVVEPTVEVTFVEEPVVEVTTVVEEVKPETQPEPTSVSEVAPSQPLSWSSIVSQ 6506
                   |..:|         |.|:|.....|..||...|...|.....:             |:
Mouse   585 -------STSQA---------FGEDPSSHEKTRGEEEGSENHAEKPGKRK-------------SK 620

  Fly  6507 TTEVTTNVTETRFTEEPEDKKPLEEKPKK--------PKAKKEKKTKVVEAPEPIVESSVPEAVV 6563
            :....|...|:|.  ||:..:|..:.|::        |:...:||.||.|..:.  :|:...:..
Mouse   621 SPRAETEAAESRL--EPKKLEPPPKDPEQEDQGHALPPETPADKKPKVYEKAKR--KSTRHHSEE 681

  Fly  6564 EPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVS------------EVAPSQPLSWSSIVSQAT 6616
            |...|..|        :.|.||..|...|. |.||            :..||.|||..|::....
Mouse   682 EGEAESGF--------SAVCEEEIPSAPPS-TSVSLETLRSHSEEGLDFKPSPPLSKISVIPHDL 737

  Fly  6617 ------EVTTNVTETRFTEEPEDKKPLEEKPKKPKAKKEKKTKVVEAPEPIVES---------AV 6666
                  ||........:.|..||.|..:...:.|:....:.::..||.|...|:         ::
Mouse   738 FYYPHYEVPLAAVLEAYAEGGEDLKSEDTDLEHPEDSYLQDSREEEADEDEEEAQSSQSSCSFSL 802

  Fly  6667 PEDVVEPTVEVTFVEEPVVEVTTVVEEVTPETQQEPTPVSEVAPSQPLSWSSIVSQTTEVTTN-V 6730
            |.|...|:|.               |.|:........|.|.:.|..|.|...  .|..|...| .
Mouse   803 PVDNSYPSVS---------------EHVSHVDGSSEGPTSALGPGSPPSHED--HQPKETKENGP 850

  Fly  6731 TETRFTEEPED----KKPLEEK--PKKPKAKKEKKTKVVEAPEPIVESSVPEAVVEPTVEVTFVE 6789
            .|::.::||.:    .||||||  .....:||::|.|.::.    ||||:            |:.
Mouse   851 VESQQSQEPPNPELPTKPLEEKLTEASTSSKKKEKRKHMDH----VESSL------------FIA 899

  Fly  6790 EPVVEVTTVVEEVTPE 6805
            ...|..:..:||.:.|
Mouse   900 PGTVRSSDDLEENSSE 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
Clmn	NP_444385.2	Actin-binding	1..288		40/240 (17%)
		CH	33..134	CDD:278723	8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	148..178		5/43 (12%)
		CH	191..286	CDD:278723	19/113 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..420		8/28 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..545		23/104 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	585..727		38/176 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	758..929		44/191 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47535
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010