Protein Alignment Msp300 and EPPK1

DIOPT Version :9

• Sequence 1: NP_001188695.1
• Gene: Msp300 / 3771968
• FlyBaseID: FBgn0261836
• Length: 13540
• Species: Drosophila melanogaster
• Sequence 2: NP_112598.3
• Gene: EPPK1 / 83481
• HGNCID: 15577
• Length: 5088
• Species: Homo sapiens
• Alignment Length: 5473
• Identity: 1000/5473 - (18%)
• Similarity: 1709/5473 - (31%)
• Gaps: 1847/5473 - (33%)

  Fly  8984 LALNLYLDQTNILPKTRIDVDTISQLLTLQKSS----DPIVEKETVQGETKSVEILVKKSIVESP 9044
            ||....|..:..|.:..:.::...:||..::::    ||      ..||..::...:.|.:|:..
Human    87 LARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDP------YGGEKLALFQAIGKEVVDRA 145

  Fly  9045 ---------------IEP-----IADEP------LVIET----SQSPPEPSKLLW----NLSQDN 9075
                           ::|     :|.||      |..||    |:..|....|.:    .|.:..
Human   146 LGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLDPNTLERLT 210

  Fly  9076 FLKLINHYKQTAGDAFALLP-----RTTTDTTIAQETQD----DKQKTDGITE---TVVTTTTTT 9128
            :.:|:....:..|...||||     |:......|.|..:    |:|...|:.|   ..|..:...
Human   211 YHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARA 275

  Fly  9129 ITDRVVEKTE-------------------------PDASSLPIIPTAQPLTAPTLGNLDQLRLNL 9168
            ...|.:|.|.                         |..::||:: .||..|...:..:...||
Human   276 EVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLL-EAQAATHTLVDPITGQRL-- 337

  Fly  9169 YLDDWQPASVDAHL-ADDLFDGLKRVDVA---------GSEAELDK--DKNQEQQPDG----DAK 9217
                |...:|.|.| :.:|.:.|...:.|         ||:..|.:  .|....:|..    ||:
Human   338 ----WVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQ 398

  Fly  9218 KPDGVTGIPDKDDHDSDDDDDDDDDDDDEGGKPTVPEIRKP---------NDDDDKPNDKDPGSG 9273
            ...|....|.:                         .:|.|         .|:|.:......||.
Human   399 LATGGLVCPAR-------------------------RLRLPLEAALRCGCLDEDTQRQLSQAGSF 438

  Fly  9274 SSGNVTPTPEHDAQYGQNRSCSSEYRSTDLPGGVGHWRDDSTYLALEAEQPQVKLESVPLAPTIS 9338
            |.|.      |                    ||:.:    ...|||....|:..|..:||
Human   439 SDGT------H--------------------GGLRY----EQLLALCVTDPETGLAFLPL----- 468

  Fly  9339 GVESVLTETNTTSPAPAPDPVTAPETSPSTTTSSLNVANALIQLASATTHTLSAKANAAATATHA 9403
                        |..|.......|.....:|..:|:.|.|.:.:.......:|......:.|..:
Human   469 ------------SGGPRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISS 521

  Fly  9404 AALAATSALLPVATAVVDKLTTTTTAAAETPAATSDV--AAVNPYVARATPAATTVAEAATAAAA 9466
            ...|..:......|..|:||....:|..|..|||:.|  :.:...|   ||.....||...   .
Human   522 EQRAMLAQQYQEGTLSVEKLAAKLSATLEQAAATARVTFSGLRDTV---TPGELLKAEIID---Q 580

  Fly  9467 EIPPAATHTETTTTSSSSGEVVALPTENTGAV----------------RRTTTTTTTVTTTTTVE 9515
            ::.....|.:.|.....|...|....:.||.:                .|........|....:|
Human   581 DLYERLEHGQATAKDVGSLASVQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLE 645

  Fly  9516 TPSTTSNTTTTTTTTSSNELQEQRQKDLITQELDELLQSLSSVEDGIA--------NMNQSSLDG 9572
            ..:.| ...........:.::|..:..:|..::...|.|......|..        ::.|:...|
Human   646 AQAAT-GFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKG 709

  Fly  9573 ML---HGLKLIQSNL-------EVHERDAIELKNQAKKLPTDPATER----------LLNDTVDR 9617
            ::   ||::|:::.:       .||          :.::|.|.|..|          ||:.:.|.
Human   710 LIVREHGIRLLEAQIATGGVIDPVH----------SHRVPVDVAYRRGYFDQMLNLILLDPSDDT 764

  Fly  9618 IDLLLRRTQQGITMIANAMHGQKKRQQEIDEYQQHLLELEQWIIEVSAELASFEPTSDSSTDE-- 9680
            .......|.:.:|.:  .:..:..|..|...|   ||.|.          ::..|..||:|.:
Human   765 KGFFDPNTHENLTYL--QLLERCVRDPETGLY---LLPLS----------STQSPLVDSATQQAF 814

  Fly  9681 --------------------QVLKSQV---ERSQQLLRTLKDRQQSM---EDLVEQTRQLQSHPD 9719
                                :::.|:.   .|.:||||..:.|:.::   ..|:|...|.|
Human   815 QNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQVAKLLEAETQRQ---- 875

  Fly  9720 VSPLADTLMEQLQSIITILREQVTVATKRIFTIEKRIVDLRKAKSEEAQRQRVLADSLIKPPTEA 9784
                ||.::..|:|.:|:  .|:..|.    .|:::::|            :|||.::
Human   876 ----ADIMLPALRSRVTV--HQLLEAG----IIDQQLLD------------QVLAGTI------- 911

  Fly  9785 PASPEAHESIESNENTI-DSSSMPEEEIKPTGVYVETQTSLSLQQPPVQVVTTTTVEAQTSFKEP 9848
              ||||...::.....: ...::....:.|:|      ..|||.|...|.:.
Human   912 --SPEALLLMDGVRRYLCGLGAVGGVRLLPSG------QRLSLYQAMRQKLL------------- 955

  Fly  9849 AVETAEVALQTQKERSPTENIMVTQTVHHGQETIQIDTTRNKDVPDEPEDVQIEARYHQRPKGDV 9913
               ...|||...:.::.|..||                     .|..||.:.:
Human   956 ---GPRVALALLEAQAATGTIM---------------------DPHSPESLSV------------ 984

  Fly  9914 DRATELILKNVPQAFETTFVEPDETTTEVIVGPDGTKHIVLKKVTRTRQQVV------QQQQISS 9972
                                  ||.....:|||:     :..::.|....:.      ..:|:|.
Human   985 ----------------------DEAVRRGVVGPE-----LYGRLKRAEGAIAGFRDPFSGKQVSV 1022

  Fly  9973 IETISDSDGNIEVHSTGQINLENVHTTDTKADPEEGSVHTVITQQTRGAVVDSTQ---------- 10027
            .:.:          ..|.|             |.|.:...:..|...|.::|.|.
Human  1023 FQAM----------KKGLI-------------PWEQAARLLEAQVATGGIIDPTSHHHLPMPVAI 1064

  Fly 10028 PEGVILQEFET--EPTIETYEEVIAPG--SQAQLIPMQPGDVQTQGTIRAVVQQVTRKVIRKTRK 10088
            ..|.:.||.||  ..:.||:......|  |.|||:...|.| :|.| :..:....:...:....:
Human  1065 QRGYVDQEMETALSSSSETFPTPDGQGRTSYAQLLEECPRD-ETSG-LHLLPLPESAPALPTEEQ 1127

  Fly 10089 IIKRVVIIDGKE------------HITEE----VVEEPEEVEITEEETAPHINVNIVRTVDGKVV 10137
            :.:.:..:.|.:            |.|||    ::|:.:|    ...|.|.:..::
Human  1128 VQRSLQAVPGAKDGTSLWDLLSSCHFTEEQRRGLLEDVQE----GRTTVPQLLASV--------- 1179

  Fly 10138 SEEEFQRMMQEPGVLIEEVATDLQKPTAE-PQQEVFD---IESTQVTTTTRTTTATTQEQEQPEQ 10198
                 ||.:||. .|:.:....:..|..| |...:.|   |....:....:.|.:..|..|||..
Human  1180 -----QRWVQET-KLLAQARVMVPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAV 1238

  Fly 10199 QT-------------QPTTTETTKEAPVELPAPQVDVEQPVVVATTSPVHVPTADVVEPKDSSPT 10250
            :.             ||:..:.:....|........:.|.::.|     .|.:..:|:|.::...
Human  1239 KACLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEA-----QVASGFLVDPLNNQRL 1298

  Fly 10251 STTAAVVDVEAVVEDINE----------------------IW-PLEHHLKPTN------------ 10280
            |...| |.|..|..:::|                      :| .:|..|.|.|
Human  1299 SVEDA-VKVGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLAT 1362

  Fly 10281 ---ID--FSQHVEELAAPAAVTAETEASMPVEEIWPTSPETGNSLTLEQYEFEPQSPHEESTKSD 10340
               :|  ...|:.:.||......:|:.|..:     |:.:..|     ::.|:|.:       .|
Human  1363 GGVVDPVHGVHLPQAAACRLGLLDTQTSQVL-----TAVDKDN-----KFFFDPSA-------RD 1410

  Fly 10341 LVKPQETEPQVVAETKPEGITTGSITITKTTTTITS----------STEVPEET----------- 10384
            .|..|:...:.|.:::     ||.:.:...:.|:..          :.:||..|
Human  1411 QVTYQQLRERCVCDSE-----TGLLLLPLPSDTVLEVDDHTAVALRAMKVPVSTGRFKGCSVSLW 1470

  Fly 10385 ---LVQNVPADEQQPPANKIKTDIQSFLEAEQTLAAALKEQSSTPTGASVAEDVQTQPEEIVLEE 10446
               |.:.|.||:::        ::.:...:.:  ||||::..|..|  ::.|..:.||.:.....
Human  1471 DLLLSEYVGADKRR--------ELVALCRSGR--AAALRQVVSAVT--TLVEAAERQPLQATFRG 1523

  Fly 10447 RTVEIS----------TIKT-EENQQEPVIVEEVKSLPVEPEPVEPELEE---VAIAIVEQTEEK 10497
            ...::|          :.|| :|..|....|:||    .|.:.|:..||.   :|..:::.|:|:
Human  1524 LRKQVSARDLFRAQLISRKTLDELSQGTTTVKEV----AEMDSVKRSLEGGNFIAGVLIQGTQER 1584

  Fly 10498 PEEPVIEKQPASGPIDLRAATQLFISGEAAASTAPQKTFQISAPSLEDNGAGVLKVVLGKESTNE 10562
            ...|...::..     ||..|.|.:. ||.|:|                 ..::..|..::.|.|
Human  1585 MSIPEALRRHI-----LRPGTALVLL-EAQAAT-----------------GFIIDPVENRKLTVE 1626

  Fly 10563 EDTAAPTTGK---VSMTIIETAAAPAADAKRRRK----KKKRRDTKHEEE----LEQEQETEPEP 10616
            |...|...||   |.:...|.|.....|....::    :..::|....|.    ||.:..|
Human  1627 EAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIAT---- 1687

  Fly 10617 VAAVKEPEVSSDVPV------------------SPEDSPR---DTVRHESIVEISPDSDLSSIEI 10660
             ..:.:|..|..|||                  .|.|..:   |...||::
Human  1688 -GGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENL-------------- 1737

  Fly 10661 DTKVKIVEDAVVSSPSESPRTPMVELVIPTEVVELALVEDEEQQTTPRIPSPTEKSEVEQDIKSV 10725
             |.::::|..|     |.|.|.:..|.|..:......:.:..:..   :.|.|.|..|.:
Human  1738 -TYLQLLERCV-----EDPETGLYLLQIIKKGENYVYINEATRHV---LQSRTAKMRVGR----- 1788

  Fly 10726 QTSPQHQPKLDETAVQTSLEVQPDNQENESQTLIVEITETEAQTTPRSEEQSVAVEISTTEIQTD 10790
                    ..|:......|...|...|:..:.|   |.|..||
Human  1789 --------FADQVVSFWDLLSSPYFTEDRKREL---IQEYGAQ---------------------- 1820

  Fly 10791 VSGQPAETVEISSQTTVTTTIEKELQTTPKDSPRAP---EAGSSDVVESLVQDLVKDMTTDLPVR 10852
             ||...:.:||     :||||| |.:|..:....|.   |..::|:..|.|.| .|.:.|....|
Human  1821 -SGGLEKLLEI-----ITTTIE-ETETQNQGIKVAAIRGEVTAADLFNSRVID-QKTLHTLRVGR 1877

  Fly 10853 TSEQSTVTETTTTTETHVQ-------TTTPEPREQTEVIKPETAHEETSTVELV----------- 10899
            |..|:  ..|....:.:::       .|.|..||...:       .|.|..||:
Human  1878 TGGQA--LSTLECVKPYLEGSGCIAGVTVPSTREVMSL-------HEASRKELIPAAFATWLLEA 1933

  Fly 10900 QFADGEMQTTPPGDQQPASLDDSSLTATSISV--SEPYELEVKTTVAI-----PADSDT------ 10951
            |.|.|.:  ..|..:|..|:|:    |..:.:  .|..|..:|...|.     ||..||
Human  1934 QAATGFL--LDPCTRQKLSVDE----AVDVGLVNEELRERLLKAERAATGYRDPATGDTIPLFQA 1992

  Fly 10952 -----------------SVAEPTVYEYTQTMQLPKQEKKSK-----------KDKKKKQKNVPEV 10988
                             .||...|.:.....:||.:....:           .|:|..:|...:.
Human  1993 MQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDP 2057

  Fly 10989 EQQLPEDQQIS---VTVEIAPELLSESG-IVVSTNQQIEDVPHVTPVVDTPIESEEVE-TPKAQR 11048
            ..|    :::|   :.....|:  .::| ::...|:...|..|:.......:|:|:|| |....|
Human  2058 NTQ----EKVSYRELQERCRPQ--EDTGWLLFPVNKAARDSEHIDDETRRALEAEQVEITVGRFR 2116

  Fly 11049 VQLQITKTTVYDEYPDLPVHITEQNKVLIASQQSKRSGAGPTSSAVTIEEVGSPTEELVVPITPG 11113
            .|.......:..||      :||:.|:.:.....       |.:...::.|.....||:
Human  2117 GQKPTLWALLNSEY------VTEEKKLQLVRMYR-------THTRRALQTVAQLILELI------ 2162

  Fly 11114 PDNLSGEPHNIWFSATTSVDKTPIELSQALIMSESLQHYPGQQKLTQE----------------- 11161
             :.......::||............||.|:|..|.||.....:..|||
Human  2163 -EKQETSNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCI 2226

  Fly 11162 -PILISTKEAIGDRIK-QLKQA---------------SPQQAT-----PLSNVLHLAT------- 11197
             .:|:..|:..|.:.| .:.||               ..|.||     |:.| |.|:.
Human  2227 AGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRN-LRLSVEEAVAAG 2290

  Fly 11198 ------------------------LSEQIKELPTEQRILEVNE-GLKDLDVAIKNGDKTVIQTTV 11237
                                    ..:||......|:.|.|.| |::.|:..|..|.
Human  2291 VVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGG-------- 2347

  Fly 11238 ITVIEKVSTWLETIE--YRVYLIRQNSNE---GPSEEKLDNYNQLNDELSTIKQNVVQLERQLSK 11297
              ||:.|.:....::  ||.....:..|.   .||::....::....|..|    .|||   |.:
Human  2348 --VIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT----YVQL---LRR 2403

  Fly 11298 AEPEPQ----LLQ------CVDSLKEHV-----DAVEQVTQQNQVQDSNDLDKWHNFEVLLYNVS 11347
            ..|:|.    :||      .|..|.|.:     ||  :||..:.......:..|   |:|.|.
Human  2404 CVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDA--RVTPGSGALQGQSVSVW---ELLFYR-- 2461

  Fly 11348 SVLADLQQSYDLLINQEYPLSAKLAQLDELEQQHEAAQQQLAHLCQNARAFQRDFPGKKMPQDVH 11412
            .|..|.:|  ||       ||...|....:|:........||.....|||.......:..|::..
Human  2462 EVSEDRRQ--DL-------LSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREAL 2517

  Fly 11413 NAFETSKNIANNIQAERERVLQL-QSLAEEY------EQTLKEF-----------TKITVLADKL 11459
            .|......:..    .|.|.:.: ..||..|      |:.|.||           .::|.:.::.
Human  2518 RAATMEVKVGR----LRGRAVPVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEA 2578

  Fly 11460 VESPIVSSSLEQL--------------NNEVQKQRKFFVNLSHCRAMLESLEENIDSETREKHSE 11510
            .|:|.....|:..              .:..:.||                |...:.||:|..:.
Human  2579 EEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQR----------------EGQGEGETQEAAAA 2627

  Fly 11511 LHKELYNRATSLLDKAS---ERSSKLVQAASRWTV-----LEKGMRDELQWLQVAQQR-----VP 11562
            .......|....|..|:   :|.....:..|.|.|     |.:..||||    :||..     :|
Human  2628 AAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDEL----LAQHAAGALGLP 2688

  Fly 11563 DLSAVTSADYDQYTTLYQSLSNDISHHYVKMTQL--SGI--ANKLQLLVQAPNLVEETNEALIVL 11623
            ||.||.:...::.......:|.......|..::|  |||  ...|:.|.|....::|..|
Human  2689 DLVAVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTE----- 2748

  Fly 11624 LKLREEVALYLHRLLVFKEIWVQYEQQTDKLEAF-VREAEQE----------LRNIQIPSQPTHQ 11677
               .:.|..||........:.|..:.|..:.|.. :.:|..:          |...|..:.....
Human  2749 ---MDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVID 2810

  Fly 11678 PIEHMRQFWEIKARFELHNNVRTDTGLSFEKSLQVIPLADEMLQRQFHAQLEDRWQAV------- 11735
            |:.::|                    ||.|:::....:..|:.::...|:     :||
Human  2811 PVRNLR--------------------LSVEEAVAAGVVGGEIQEKLLSAE-----RAVTGYTDPY 2850

  Fly 11736 -AQAIELIQHNIVECLSSEDVPADEKLKMVERELQEIYLTMTSMKGVIKNEEELCLYIERVQV-L 11798
             .|.|.|.|     .:..:.:..:..::::|.::        :..|||..     ::..||.| :
Human  2851 TGQQISLFQ-----AMQKDLIVREHGIRLLEAQI--------ATGGVIDP-----VHSHRVPVDV 2897

  Fly 11799 RTRVGFIGNELGRI---------GLQEP---------------AIEPEKVGELFSLSHKIST--Q 11837
            ..:.|:...|:.|:         |..:|               ..:|:....:..|:.:.|.  |
Human  2898 AYQRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRGSAVHQ 2962

  Fly 11838 IAEELEGASVLRDQLQAIQEGISNQRKHQAKISVILDECEAAERQGADVLEKAVADCQAAGEELV 11902
            ::|||..|  |||  ..:..|....:.....:..:|...|.:|.:..|:|.:     ..||
Human  2963 LSEELRCA--LRD--ARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSR-----YRAG---- 3014

  Fly 11903 ISWQEIMRIRQMLHTLPMRLKMSVSPVKLERDISQLQDD------HAFLESKCTNIMAILRSR-L 11960
                 .:.:.::..||...|..:.:..:.|.:....:.|      .|.:|.|    :..||.| :
Human  3015 -----TLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVK----VGRLRGRAV 3070

  Fly 11961 AVW-----------LRYERQLELVHGSVQETDFMMELIRVHGQVDYERLRKATERLEGLAGDLHN 12014
            .||           .|.|...|...|::.    :..|.|        ||....|..|...|   .
Human  3071 PVWDVLASGYVSRAAREELLAEFGSGTLD----LPALTR--------RLTAIIEEAEEAPG---A 3120

  Fly 12015 REQLIDELKGAAKPLI------ESCDVQIVEQIESAVQEAVVAWNDTSENLQQLRTRYQRA---- 12069
            |.||.|..:|..:|..      :|...|...|.|...|||..|.....:.|:......||.
Human  3121 RPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAARRQEQTLRDATMEVQRGQFQG 3185

  Fly 12070 --VELWDKYRNASAAVKNSIDQQMDAVKSLEQPLDALQHAKVCQDNLTTQNDR-ILELRDIVAKI 12131
              |.:||...::                       .|..|:  :|.|..|:.. .|.|.|:||.:
Human  3186 RPVSVWDVLFSS-----------------------YLSEAR--RDELLAQHAAGALGLPDLVAVL 3225

  Fly 12132 AADV-------------GLDASALMQGELDALG----QRLAECKDAITTLANVAETQDKERKELD 12179
            ...:             ||... :...||...|    :.|.:......||..|.| .|..::.|:
Human  3226 TRVIEETEERLSKVSFRGLRCQ-VSASELHTSGILGPETLRDLAQGTKTLQEVTE-MDSVKRYLE 3288

  Fly 12180 KEVTLAKAYFNNVQQDISREAPQNPKESEEQ----------------LAALRAHLQTLARTEEQL 12228
            ....:|         .:...|...|...|:.                |..|.|...| ....:.:
Human  3289 GTSCIA---------GVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAAT-GFVIDPV 3343

  Fly 12229 RQLKERHQNSEVAPSVASSDDDGIL---------------EVLALWQKIFQDTFQEYHRLSTRLA 12278
            |.|:...:.:..|..|.....:.:|               :.::|:|.:.:|.....|.:  ||.
Human  3344 RNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGI--RLL 3406

  Fly 12279 RSQNSSEALRLWRQYLQHVQSFLSCAIPEDYSSLR-----EQQQLCA-------------IHQNL 12325
            .:|.::..:         :....|..:|.|.:..|     |..::.|             .|:||
Human  3407 EAQIATGGV---------IDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENL 3462

  Fly 12326 LISQ---------------QSVLSETPLESELSEQYK-ALTNLHNETLSRIMQRNGELE-RRVSG 12373
            ...|               ..:........:|||:.: ||.:      :|:...:|.|: :.||.
Human  3463 TYVQLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRD------ARVTPGSGALQGQSVSV 3521

  Fly 12374 WNAYRQQLAALLDWLRQREAERNALQLRY-IHLKRVPHLKHRLDAMIQQLDQGEQQSKALQEQQQ 12437
            |.        ||.:....|..|..|..|| .....|..|...|.::   |.|.:.|::|
Human  3522 WE--------LLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSL---LAQAQAQARA------ 3569

  Fly 12438 ELARHCDDALATAMR------MEQASIGQRISNLRA-ALKTW----QGFLQRVTQLSESYEQRVN 12491
                   :|.|.:.|      :..|::..::..||. |:..|    .|::.|..:         .
Human  3570 -------EAEAGSPRPDPREALRAATMEVKVGRLRGRAVPVWDVLASGYVSRAAR---------E 3618

  Fly 12492 QLQQEFG-------AAQKLLDANSESLPTQPAAIEQLL-----------------GSLRAQRVQL 12532
            :|..|||       |..:.|.|..|.....|.|..||.                 .|.|:||...
Human  3619 ELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQ 3683

  Fly 12533 G---AQVSALESLTVTQEE--LKECISPHDMKTIRQRNWLLWQ-----------------QHA-- 12573
            |   .|.:|..:....::|  |::..........:.|...:|.                 |||
Human  3684 GEGETQEAAAATAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAG 3748

  Fly 12574 -----DLDYQLANLINSIEERLSLLSNYQIRYDRISQWLQRLEQRVEKDADVTAMTNPE------ 12627
                 ||...|..:|...|||||.:|...:|           .|....:...:.:..||
Human  3749 ALGLPDLVAVLTRVIEETEERLSKVSFRGLR-----------RQVSASELHTSGILGPETLRDLA 3802

  Fly 12628 QAAKQLEQQVNSELQLRDKEREWLLSTS---------------RELLTLYS-------EPE---V 12667
            |..|.|:     |:...|..:.:|..||               :|.:::|.       .|.   |
Human  3803 QGTKTLQ-----EVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALV 3862

  Fly 12668 RSQVQQQSDSLIDRWQRLKYLAKQKATKI----GELKMTLLRLE------------ERIALIRAW 12716
            ..:.|..:..:||..:.|: |:.::|...    ||::..||..|            ::|:|.:|
Human  3863 LLEAQAATGFVIDPVRNLR-LSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQA- 3925

  Fly 12717 LFEVESQLDKPLNFESYTPNVIEAKL---------KEH--------------EQIQRSIEHHSS- 12757
                   :.|.|....:...::||::         ..|              |::.|.:...|.
Human  3926 -------MQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDD 3983

  Fly 12758 -------NVGEVLNLVEML---LNDADSWRTQVNTSGLAASAQNLEQRWKNVCSQSAERKARI-- 12810
                   |..|.|..|::|   :.|.|:....:..:|..::...|.:..:  |   |.|.||:
Human  3984 TKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELR--C---ALRDARVTP 4043

  Fly 12811 ---------LTIWNLLQQLIKLTAEHKNWLGKQESQIAGFERDQKSHSKHKLEERQMELRAKLEE 12866
                     :::|.||                       |.|:.....:..|..|.......:||
Human  4044 GSGALQGQSVSVWELL-----------------------FYREVSEDRRQDLLSRYRAGTLTVEE 4085

  Fly 12867 LESQSVNLRQLEQIYAKLAMSAG---VEP-ENIQKLTLPTKV------MVSMWRQLTPRCHALLD 12921
            |.:...:|....|..|:....||   .:| |.::..|:..||      .|.:|..|..      .
Human  4086 LGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPVWDVLAS------G 4144

  Fly 12922 AIDKDAK--LMREFNNAQLE---ATNSLNAIQKALEQLPSAENQ--------------------- 12960
            .:.:.|:  |:.||.:..|:   .|..|.||.:..|:.|.|..|
Human  4145 YVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDS 4209

  Fly 12961 -----------QTSKAEPKAVLQRLESLEKKLQDAQQHVQQA----------DNLAQEAKTRTKQ 13004
                       :|.:|.......|.:  |:.|:||...||:.          |.|.....:..::
Human  4210 GRSQREGQGEGETQEAAAATAAARRQ--EQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLSEARR 4272

  Fly 13005 QPQLKQ-------LLELVSAYTTLWQTVQTRIVTLKTTWLTRAAQAAASLPVSEAANAAVQVNTL 13062
            ...|.|       |.:||:..|.:.:..:.|:..:....|.|...|      ||...:.:    |
Human  4273 DELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSA------SELHTSGI----L 4327

  Fly 13063 SQRKLRQ-AQQMQRETSITAKDAYIMELQTAITECQNNLDELQRTVVDKTRKPGPQKIAKLL--- 13123
            ....||. ||..:....:|..|:....|:.  |.|      :...:|....:||.|:...:.
Human  4328 GPETLRDLAQGTKTLQEVTEMDSVKRYLEG--TSC------IAGVLVPAKDQPGHQEKMSIYQAM 4384

  Fly 13124 --GNAQSSTELVKHLSHLLLTECKADDQAAE---VDTVAELTLRFD----------TLQSQWKAR 13173
              |..:..|.||      ||     :.|||.   :|.|..|.|..:          .:|.:..:.
Human  4385 WKGVLRPGTALV------LL-----EAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSA 4438

  Fly 13174 QQHDQNASEVGRLTCPLCTQR--NWQQIDNDLWRLEQWLQFAESTQKAQSAPPSNIELLED---- 13232
            ::      .|...|.|...|:  .:|.:..||...|..::..|    ||.|....|:.:..
Human  4439 ER------AVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLE----AQIATGGVIDPVHSHRVP 4493

  Fly 13233 VTQDHREFLLDLESHKSIISSLNVVGDHLATHTLDTEKARQLRSRLEADNERWNNVCINATKWQG 13297
            |...:|....|.|.::.:....:........:|.:.....||..|...|.:            .|
Human  4494 VDVAYRRGYFDEEMNRVLAHPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD------------TG 4546

  Fly 13298 LLQTALMG-NSEFHQTIGELVEWLQRTEQNIKASEPVDLTEERSVLETKFKKFKDLRAELERCEP 13361
            |....|.| .|..||...||                                         ||
Human  4547 LYMLQLAGRGSAVHQLSEEL-----------------------------------------RC-- 4568

  Fly 13362 RVVSLQDAADQLLRSVEGS---EQQSQHTYE----RTLSRLTDLRLRLQSLRRLSGIYIVKLGAV 13419
               :|:||     |.:.||   :.||...:|    |.:|.  |.|..|.|..|...:.:.:|||.
Human  4569 ---ALRDA-----RVMPGSGALQGQSVSVWELLFYREVSE--DRRQDLLSRYRAGTLTVEELGAT 4623

  Fly 13420 LGYEGDNLGVPLHMLSSELLDNTTLSTSSMQAAAPNTENANN--TDGGDAVDGDVINTTVLARGA 13482
            |                    .:.|:.:..||.|.....|.:  .|..:|:....:...|
Human  4624 L--------------------TSLLAQAQAQARAEAEAEAGSPRPDPREALRAATMEVKV----- 4663

  Fly 13483 RFLGRVARASLPI 13495
               ||:...::|:
Human  4664 ---GRLRGRAVPV 4673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325	42/241 (17%)
		sbcc	11187..12008	CDD:129705	185/990 (19%)
		SMC_prok_B	11614..12442	CDD:274008	176/988 (18%)
		SPEC	11994..12156	CDD:295325	41/191 (21%)
		SPEC	12374..12564	CDD:295325	46/230 (20%)
		Lipase_chap	12376..12529	CDD:281297	38/188 (20%)
		SPEC	12703..12923	CDD:238103	51/286 (18%)
		SPEC	12816..13032	CDD:295325	53/279 (19%)
		SPEC	13196..13374	CDD:238103	32/182 (18%)
		KASH	13484..13540	CDD:287506	3/12 (25%)
EPPK1	NP_112598.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		Plectin 1	34..71
		Interaction with KRT5. /evidence=ECO:0000250|UniProtKB:Q8R0W0	42..1115		223/1286 (17%)
		Plectin	74..113	CDD:307019	4/25 (16%)
		Plectin	151..189	CDD:307019	7/37 (19%)
		Plectin	317..357	CDD:307019	11/46 (24%)
		Plectin	393..433	CDD:307019	8/64 (13%)
		Plectin	604..644	CDD:307019	4/39 (10%)
		Plectin	643..682	CDD:307019	4/39 (10%)
		PLEC	679..716	CDD:197605	5/36 (14%)
		Plectin	718..758	CDD:307019	7/49 (14%)
		Plectin	969..1001	CDD:307019	11/91 (12%)
		PLEC	1000..1036	CDD:197605	7/58 (12%)
		Plectin	1038..1078	CDD:307019	9/39 (23%)
		Plectin 21	1239..1276		3/36 (8%)
		Plectin 22	1277..1314		10/42 (24%)
		Plectin	1278..1317	CDD:307019	10/44 (23%)
		Plectin 23	1315..1352		6/36 (17%)
		Plectin 24	1353..1390		5/36 (14%)
		Plectin	1354..1393	CDD:307019	6/38 (16%)
		Plectin 25	1391..1428		8/58 (14%)
		Plectin 26	1564..1601		8/41 (20%)
		Plectin	1565..1605	CDD:307019	10/44 (23%)
		Interaction with KRT5. /evidence=ECO:0000250|UniProtKB:Q8R0W0	1572..5085		689/3666 (19%)
		Plectin	1603..1643	CDD:307019	12/57 (21%)
		PLEC	1641..1677	CDD:197605	5/35 (14%)
		Plectin	1679..1718	CDD:307019	8/43 (19%)
		Plectin	1891..1931	CDD:307019	8/46 (17%)
		Plectin	1930..1969	CDD:307019	10/44 (23%)
		Plectin	2005..2045	CDD:307019	5/39 (13%)
		Plectin	2218..2263	CDD:307019	6/44 (14%)
		Plectin	2261..2301	CDD:307019	7/40 (18%)
		PLEC	2299..2335	CDD:197605	6/35 (17%)
		Plectin	2337..2376	CDD:307019	9/48 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2578..2637		10/74 (14%)
		Plectin	2754..2799	CDD:307019	6/44 (14%)
		Interaction with KRT14. /evidence=ECO:0000250|UniProtKB:Q8R0W0	2761..2953		32/234 (14%)
		Plectin	2797..2837	CDD:307019	8/59 (14%)
		PLEC	2835..2871	CDD:197605	7/45 (16%)
		Plectin	2873..2912	CDD:307019	10/51 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3114..3168		16/56 (29%)
		Plectin	3285..3330	CDD:307019	6/53 (11%)
		Plectin	3328..3368	CDD:307019	7/40 (18%)
		PLEC	3366..3402	CDD:197605	4/35 (11%)
		Plectin	3404..3443	CDD:307019	8/47 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3645..3702		11/56 (20%)
		Plectin	3819..3864	CDD:307019	7/44 (16%)
		Plectin	3862..3902	CDD:307019	9/40 (23%)
		PLEC	3900..3936	CDD:197605	8/43 (19%)
		Plectin	3938..3977	CDD:307019	5/38 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4179..4236		7/58 (12%)
		Plectin	4353..4398	CDD:307019	11/58 (19%)
		Plectin	4396..4436	CDD:307019	11/50 (22%)
		PLEC	4434..4470	CDD:197605	8/41 (20%)
		Plectin	4472..4511	CDD:307019	9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	4715..4769
		Plectin	4886..4931	CDD:307019
		Plectin	4929..4969	CDD:307019
		PLEC	4967..5003	CDD:197605
		Plectin	5005..5044	CDD:307019

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900