DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Msp300 and CLMN

DIOPT Version :9

Sequence 1:	NP_001188695.1	Gene:	Msp300 / 3771968	FlyBaseID:	FBgn0261836	Length:	13540	Species:	Drosophila melanogaster
Sequence 2:	XP_011535460.1	Gene:	CLMN / 79789	HGNCID:	19972	Length:	1033	Species:	Homo sapiens

Alignment Length:	987	Identity:	183/987 - (18%)
Similarity:	326/987 - (33%)	Gaps:	323/987 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  4771 SDDEEEPVPEPVKEETLVKEVVEEKPIVEVSVVDDSKSITTVTTTTTTTETISELPIPEEPKKVV 4835
            :|.:....|.|..|.:           |.:||.|..|:|..:....
Human   163 TDSDSSFPPTPTAERS-----------VAISVKDQRKAIKALLAWV------------------- 197

  Fly  4836 EPEKKPEEPKKPAYAGLPVDDSSNSWMDVLDEPMNFSDDEEEPIPEPLKEETVVEEVVEIKPIVE 4900
                    .:|....|:.|.|.:.||...|                         ..:.:...::
Human   198 --------QRKTRKYGVAVQDFAGSWRSGL-------------------------AFLAVIKAID 229

  Fly  4901 VSVVDDSKTITTVTTTTITTETISELPISEEP---KKVVEPE----KKPEEPKKPAYAG------ 4952
            .|:||..:.:...|...:.    ....|:::.   .:::|||    ..|:|.....|..
Human   230 PSLVDMKQALENSTRENLE----KAFSIAQDALHIPRLLEPEDIMVDTPDEQSIMTYVAQFLERF 290

  Fly  4953 --LPVDDSTNSWMDVLDEPMNFSDDEEEPVPEPVKEETLVEEVVEEKPIVEVSVVDDSKTITTVT 5015
              |..:|.             |..|:|.|:     |.|.|.  ::|.|..:     :|| :..:|
Human   291 PELEAEDI-------------FDSDKEVPI-----ESTFVR--IKETPSEQ-----ESK-VFVLT 329

  Fly  5016 TTTTTTETISEPVISEQPKKTVEPVKKPEESTEVEPKPLSSNIWELHSSYADVLRHTVDFISLEK 5080
            .....|.|::... |..|...|....|||...|.....:||:  .|..|..:.:...:|.:
Human   330 ENGERTYTVNHET-SHPPPSKVFVCDKPESMKEFRLDGVSSH--ALSDSSTEFMHQIIDQV---- 387

  Fly  5081 NNVEVPTESNLGKVPTVKEPAKLPEPLIKTKAKKEKPLKKEKGAKLLTPKDEVLPIERESAKDET 5145
                  .:...||...:.||:  ||..|.:.       :||.|.....|..:.:..|.::.||..
Human   388 ------LQGGPGKTSDISEPS--PESSILSS-------RKENGRSNSLPIKKTVHFEADTYKDPF 437

  Fly  5146 KTSWSTMVENDFDDNVQTNILSADSTLWSSIVRQGAQEPITKMTQSADHDGKVLEPAFQNSQEIN 5210
                           ...|:         |:..:|:.. :.|  :|...||.||      :.|:.
Human   438 ---------------CSKNL---------SLCFEGSPR-VAK--ESLRQDGHVL------AVEVA 469

  Fly  5211 KFISQERSSTVIEKTKKQK--------------SKKEKKHNKIESVV-----EVALEPYVDSTFM 5256
            :...|::.|:.|.::...|              |:....:..:||..     ..:|.|..::|.|
Human   470 EEKEQKQESSKIPESSSDKVAGDIFLVEGTNNNSQSSSCNGALESTARHDEESHSLSPPGENTVM 534

  Fly  5257 RDDPKTQQN------AEIPSVLESLPIQPKSWSSIVSQTEVLPPTSIESKISQKAVDPHRSKEVQ 5315
            .|..:.:.|      .|.....|::|::...::|     :::...| .|:...|...||.:|..:
Human   535 ADSFQIKVNLMTVEALEEGDYFEAIPLKASKFNS-----DLIDFAS-TSQAFNKVPSPHETKPDE 593

  Fly  5316 ---------EFISKEQIFSTTVNADSKKPE-----------------------DKKPLEEKPKKQ 5348
                     |.:.|..|.|.....||.:|:                       ::.|:::||:..
Human   594 DAEAFENHAEKLGKRSIKSAHKKKDSPEPQVKMDKHEPHQDSGEEAEGCPSAPEETPVDKKPEVH 658

  Fly  5349 KSKKEKKTKVVEAPEPIVESAVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVS--- 5410
            :..|.|.|:                   |..|....::   ::..|.||::  :.|..:.||
Human   659 EKAKRKSTR-------------------PHYEEEGEDD---DLQGVGEELS--SSPPSSCVSLET 699

  Fly  5411 ---------EVAPSQPLSWSSIVSQTT------EVTTNVTETRFTEEPEDKKPLE---EKPKKQK 5457
                     :..||.|||..|::....      ||........:.|:|||.|..|   |:|:...
Human   700 LGSHSEEGLDFKPSPPLSKVSVIPHDLFYFPHYEVPLAAVLEAYVEDPEDLKNEEMDLEEPEGYM 764

  Fly  5458 PKKEKKTKVVEAPEPIVESAVP-EAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVA 5521
            |..:.:.:..:..:....|:|| |::...:.:|.::....|. ||...|..|....|.....|..
Human   765 PDLDSREEEADGSQSSSSSSVPGESLPSASDQVLYLSRGGVG-TTPASEPAPLAPHEDHQQRETK 828

  Fly  5522 PSQPLSWSSIVSQTTEITTNVTETRFTEEPEDKKPLEEKPKKQ--KSKKEKKTKVVEAPEPIVES 5584
            .:.|:  .|..||.:....|:.           .||||...|:  .|||::|.|.|:.    |||
Human   829 ENDPM--DSHQSQESPNLENIA-----------NPLEENVTKESISSKKKEKRKHVDH----VES 876

  Fly  5585 AVPEAVVEPTVEVTFVEEPVVEVTTVVEEVTPETQPEPTPVSEVAPSQPLSWSSIVSQTTEVTTN 5649
            ::            ||....|:.:..:||.:.:                   .||.|:|:...::
Human   877 SL------------FVAPGSVQSSDDLEEDSSD-------------------YSIPSRTSHSDSS 910

  Fly  5650 VTETRFTEEPED 5661
            :...|.|....:
Human   911 IYLRRHTHRSSE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Msp300	NP_001188695.1	SPEC	17..220	CDD:238103
		SPEC	9546..9732	CDD:295325
		sbcc	11187..12008	CDD:129705
		SMC_prok_B	11614..12442	CDD:274008
		SPEC	11994..12156	CDD:295325
		SPEC	12374..12564	CDD:295325
		Lipase_chap	12376..12529	CDD:281297
		SPEC	12703..12923	CDD:238103
		SPEC	12816..13032	CDD:295325
		SPEC	13196..13374	CDD:238103
		KASH	13484..13540	CDD:287506
CLMN	XP_011535460.1	CH	33..134	CDD:278723
CLMN	XP_011535460.1	CH	191..286	CDD:278723	18/150 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D46at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR47535
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010